Book Description
This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.
Author : OECD
Publisher : OECD Publishing
Page : 67 pages
File Size : 28,40 MB
Release : 2018-06-27
Category :
ISBN : 9264229825
This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.
Author : OECD
Publisher : OECD Publishing
Page : 91 pages
File Size : 49,59 MB
Release : 2024-06-25
Category :
ISBN : 9264264353
The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This TG is proposed to address the activation of dendritic cells, which is one Key Event on the Adverse Outcome Pathway (AOP) for Skin Sensitisation. It provides four in vitro test methods addressing the same Key Event on the AOP: (i) the human cell Line Activation Test or h-CLAT method, (ii) the U937 Cell Line Activation Test or U-SENS, (iii) the Interleukin-8 Reporter Gene Assay or IL-8 Luc assay and (iv) the Genomic Allergen Rapid Detection for assessment of skin sensitisers (GARDTMskin). All of them are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. The test methods described in this TG either quantify the change in the expression of cell surface marker(s) CD54 and CD86, the cytokine IL-8, or a series of genes (genomic biomarker signature) that are associated with the process of activation of monocytes and DC following exposure to sensitisers.
Author : OECD
Publisher : OECD Publishing
Page : 63 pages
File Size : 22,32 MB
Release : 2015-02-05
Category :
ISBN : 9264229701
This Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. It provides an in chemico procedure (Direct Peptide Reactivity Assay – DPRA) used for supporting the discrimination between skin sensitisers and non-sensitisers.
Author : Amy J. Clippinger
Publisher : Frontiers Media SA
Page : 139 pages
File Size : 36,63 MB
Release : 2022-12-16
Category : Science
ISBN : 2832508596
Author : OECD
Publisher : OECD Publishing
Page : 53 pages
File Size : 23,69 MB
Release : 2023-07-04
Category :
ISBN : 9264903003
A Defined Approach (DA) consists of a selection of information sources (e.g in silico predictions, in chemico, in vitro data) used in a specific combination, and resulting data are interpreted using a fixed data interpretation procedure (DIP) (e.g. a mathematical, rule-based model). DAs use methods in combination and are intended to overcome some limitations of the individual, stand-alone methods.
Author : OECD
Publisher : OECD Publishing
Page : 28 pages
File Size : 13,62 MB
Release : 2021-06-17
Category :
ISBN : 9264242848
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
Author : OECD
Publisher : OECD Publishing
Page : 105 pages
File Size : 29,11 MB
Release : 2014-09-03
Category :
ISBN : 9264221441
This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies databases containing test results related to key events.
Author : OECD
Publisher : OECD Publishing
Page : 8 pages
File Size : 10,11 MB
Release : 2004-11-23
Category :
ISBN : 9264071083
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
Author : OECD
Publisher : OECD Publishing
Page : 12 pages
File Size : 26,75 MB
Release : 1992-07-17
Category :
ISBN : 9264070664
This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application. In this Test Guideline, the methods preferred over other are: the Guinea Pig Maximisation ...
Author : Yanzhu Zhu
Publisher : Frontiers Media SA
Page : 263 pages
File Size : 32,95 MB
Release : 2022-03-10
Category : Science
ISBN : 2889746402