OECD Guidelines for the Testing of Chemicals, Section 5 Test No. 501: Metabolism in Crops


Book Description

Studies of Metabolism in Crops are used to elucidate the degradation pathway of the active ingredient and require the identification of the metabolism and/or degradation products when a pesticide is applied to a crop directly or indirectly. A ...




OECD Guidelines for the Testing of Chemicals, Section 5 Test No. 508: Magnitude of the Pesticide Residues in Processed Commodities


Book Description

This Test Guideline describes how to plan and carry out processing studies, i.e. determine residue levels in primary processed commodities following pesticide application on raw agriculture commodities (RAC) under conditions likely to lead to ...




Introduction to Toxicological Screening Methods and Good Laboratory Practice


Book Description

This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.




OECD Guidelines for the Testing of Chemicals, Section 5 Test No. 504: Residues in Rotational Crops (Limited Field Studies)


Book Description

This Test Guideline describes a method to determine the amount of pesticide residues which may be accumulated into rotational crops via soil uptake following realistic agricultural practices. These data may be used to establish crop rotation ...




Submission and evaluation of pesticide residues data for the estimation of maximum residue levels in food and feed


Book Description

This manual incorporates all relevant information and principles that are currently used by the Joint Meeting on Pesticide Residues to estimate maximum residue levels, supervised trials median residue values, and dietary risk from pesticide residues.




Manual on development and use of FAO and WHO specifications for pesticides


Book Description

The FAO/WHO Manual on development and use of FAO and WHO specifications for pesticides contains general principles and methodologies of the work undertaken by JMPS, is the continuous evaluation of new scientific developments and guidance documents. The Manual gives the historical background of the operation of the JMPS and describes the purpose of the work. The Manual is also used by countries as a guidance document in setting pesticide specifications. This 3rd revision of the Manual contains n ew methodologies/principles developed in recent 5 years and incorporates the current working principles applied by the JMPS.




Making Better Policies for Food Systems


Book Description

Food systems around the world face a triple challenge: providing food security and nutrition for a growing global population; supporting livelihoods for those working along the food supply chain; and contributing to environmental sustainability. Better policies hold tremendous promise for making progress in these domains.




Globally Harmonized System of Classification and Labelling of Chemicals (GHS).


Book Description

The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) addresses classification and labelling of chemicals by types of hazards. It provides the basis for worldwide harmonization of rules and regulations on chemicals and aims at enhancing the protection of human health and the environment during their handling, transport and use by ensuring that the information about their physical, health and environmental hazards is available. The sixth revised edition includes, inter alia, a new hazard class for desensitized explosives and a new hazard category for pyrophoric gases; miscellaneous amendments intended to further clarify the criteria for some hazard classes (explosives, specific target organ toxicity following single exposure, aspiration hazard, and hazardous to the aquatic environment) and to complement the information to be included in section 9 of the Safety Data Sheet; revised and further rationalized precautionary statements; and an example of labelling of a small packaging in Annex 7.




OECD Guidelines for the Testing of Chemicals, Section 5 Introduction to OECD Test Guidelines on Pesticide Residues Chemistry - Section 5 Part A


Book Description

The objective of OECD Test Guidelines for the pesticide residue chemistry is to assess pesticide exposure by identifying these residues in food or animal feedstuffs for purposes of dietary risk assessment and setting Maximum Residue Levels. They ...




Human and Ecological Risk Assessment


Book Description

Understand the fundamentals of human risk assessment with this introduction and reference Human risk assessments are a precondition for virtually all industrial action or environmental regulation, all the more essential in a world where chemical and environmental hazards are becoming more abundant. These documents catalog potential environmental, toxicological, ecological, or other harms resulting from a particular hazard, from chemical spills to construction projects to dangerous workplaces. They turn on a number of variables, of which the most significant is the degree of human exposure to the hazardous agent or process. Human and Ecological Risk Assessment combines the virtues of a textbook and reference work to introduce and analyze these vital documents. Beginning with the foundational theory of human health risk assessment, it then supplies case studies and detailed analysis illustrating the practice of producing risk assessment documents. Fully updated and authored by leading authorities in the field, the result is an indispensable work. Readers of the second edition of Human and Ecological Risk Assessment will also find: Over 40 entirely new case studies reflecting the latest in risk assessment practice Detailed discussion of hazards including air emissions, contaminated food and soil, hazardous waste sites, and many more Case studies from multiple countries to reflect diverse international standards Human and Ecological Risk Assessment is ideal for professionals and advanced graduate students in toxicology, industrial hygiene, occupational medicine, environmental science, and all related subjects.