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Oncogenomics

Author : Charles Brenner

Publisher : John Wiley & Sons

Page : 411 pages

File Size : 24,86 MB

Release : 2004-11-19

Category : Medical

ISBN : 0471476641

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Book Description

This book aims to assemble the only available rigorous, yet broadly accessible introduction to this new and exciting field. Oncogenomics: Molecular Approaches to Cancer is approachable by basic scientists, practitioners, and other health professionals required to familiarize themselves with the tremendous impact of genomics and proteomics on cancer research. Clearly written chapters offer reviews of state of the art topics such as molecular classification, early detection, SNPs in cancer, data mining, tissue microarrays, protein and antibody arrays, and drug targets.



Oncogenomics

Author : Franco Dammacco

Publisher : Academic Press

Page : 722 pages

File Size : 13,30 MB

Release : 2018-10-30

Category : Science

ISBN : 0128117869

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Book Description

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies. Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignancies Employs current knowledge in oncogenomics towards developing therapeutic interventions for various cancer types Features a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics and precision medicine



The Oncogenomics Handbook

Author : William J. LaRochelle

Publisher : Springer Science & Business Media

Page : 745 pages

File Size : 46,77 MB

Release : 2007-11-09

Category : Medical

ISBN : 1592598935

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Book Description

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.



Handbook of Oncogenomics

Author : Zena Murray

Publisher : American Medical Publishers

Page : 229 pages

File Size : 16,63 MB

Release : 2021-11-16

Category : Medical

ISBN : 9781639272518

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Book Description

The accumulation of DNA mutations and epigenetic variations that leads to uncontrolled cell proliferation and formation of neoplasm refers to cancer. It is a genetic disease. The sub branch of genomics that deals with the study of cancer related genes is known as oncogenomics. The primary goal of the discipline is to recognize new tumor suppressor genes and oncogenes that may lead to new insights in the diagnosis of cancer, help predict the clinical outcome of different cancers and identify new targets for cancer therapies. It uses the techniques of transciptomes, genome sequencing, bioinformatics, functional analysis of oncogenes, etc. The field is also concerned with personalizing cancer treatment by identifying and targeting mutations in an individual patient. The book elucidates the concepts and innovative models around the prospective developments with respect to oncogenomics. The various studies that are constantly contributing towards advancing technologies and evolution of this field are examined in detail. This book, with its detailed analyses and data, will prove immensely beneficial to professionals and students involved in this area at various levels.



Oncogenomics and Cancer Proteomics

Author : Cesar Lopez-Camarillo

Publisher : BoD – Books on Demand

Page : 242 pages

File Size : 37,8 MB

Release : 2013-03-13

Category : Medical

ISBN : 9535110411

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Book Description

Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer presents comprehensive reviews of the most common cancers from bench to bedside applications by an international team of experts. This book will contribute to the scientific and medical community by providing up-to-date discoveries of oncogenomics and their potential applications in cancer translational research. It is intended for students, scientists, clinicians, oncologists and health professionals working in cancer research.





Systems and Integrative Approaches in Oncogenomics

Author :

Publisher :

Page : pages

File Size : 43,15 MB

Release : 2002

Category :

ISBN :

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Book Description

Significant progress in technology has allowed systems level molecular profiling of cancer which has created a wealth of unprecedented genomics ('oncogenomics') data. Innovative and integrated approaches are needed to translate this rich information into knowledge. In this dissertation, I have explored 3 such case studies involving high throughput datasets such as RNAi screens, mutation profiling and microarrays. By generating and testing hypotheses from fusing different datasets, I have attempted to characterize genetic determinants of tumor biology and their relevance to drug discovery applications. Results include identifying novel cancer targets, shedding light on mechanism of recently discovered genetic aberrations and suggesting rational therapeutic applications for testing in the lab and clinic. These global approaches hold great promise and can be extended to enhance our understanding of the 'oncogenome' and to create opportunities for improvement of existing or future cancer treatment.



Applications of Biotechnology in Neurology

Author : Kewal K. Jain

Publisher : Springer Science & Business Media

Page : 667 pages

File Size : 36,3 MB

Release : 2013-01-05

Category : Medical

ISBN : 162703272X

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Book Description

Culling together excerpts from a wide range of writings by Dr. Kewal K. Jain on biotechnology topics as they relate to disorders of the nervous system, Applications of Biotechnology in Neurology covers a variety of applications for those working in life sciences and the pharmaceutical sciences, particularly those developing diagnostics and therapeutics for the nervous system. This detailed volume delves into areas such as neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, various methods of improving systemic administration of drugs for targeted delivery to the nervous system, including the use of nanobiotechnology, biotechnology-based strategies and products for neuroprotection, as well as chapters on neurosurgery and personalized neurology. Thorough, cutting-edge, and thoughtfully organized, Applications of Biotechnology in Neurology serves as an ideal guide, supplemented by 75 tables and 16 figures as well as numerous references from recent literature on this topic, which are appended to each chapter.



Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics

Author : Erika Ruiz-Garcia

Publisher : Springer Nature

Page : 171 pages

File Size : 24,49 MB

Release : 2019-11-11

Category : Science

ISBN : 3030241009

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Book Description

Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.



Making Sense of Genes

Author : Kostas Kampourakis

Publisher : Cambridge University Press

Page : 319 pages

File Size : 23,35 MB

Release : 2017-03-30

Category : Science

ISBN : 1107567491

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Book Description

What are genes? What do genes do? These seemingly simple questions are in fact challenging to answer accurately. As a result, there are widespread misunderstandings and over-simplistic answers, which lead to common conceptions widely portrayed in the media, such as the existence of a gene 'for' a particular characteristic or disease. In reality, the DNA we inherit interacts continuously with the environment and functions differently as we age. What our parents hand down to us is just the beginning of our life story. This comprehensive book analyses and explains the gene concept, combining philosophical, historical, psychological and educational perspectives with current research in genetics and genomics. It summarises what we currently know and do not know about genes and the potential impact of genetics on all our lives. Making Sense of Genes is an accessible but rigorous introduction to contemporary genetics concepts for non-experts, undergraduate students, teachers and healthcare professionals.