Science of Synthesis: Advances in Organoboron Chemistry towards Organic Synthesis


Book Description

The widespread use of organoboron compounds justifies the efforts devoted to their synthesis, as well as toward developing an understanding of their reactivity. The nature of the mono- or diboron species is of paramount importance in determining the reversible covalent binding properties of the boron atom with both nucleophiles and electrophiles. By wedding the rich chemical potential of organoboron compounds to the ubiquity of organic scaffolds, advanced borylation reactions have the potential to open unprecedented synthetic alternatives, and new knowledge in the field should encourage chemists to use organoboron compounds. In this volume, the main objective is to provide a collection of the most useful, practical, and reliable methods, reported mainly within the last decade, for boron activation and boron reactivity. The volume covers the main concepts of organoboron compounds and includes experimental procedures, enabling newcomers to the field the instant and reliable application of the new tools in synthesis. Rather than aiming for a comprehensive coverage, the most advanced solutions for challenging transformations are introduced. To this end, a team of pioneers and leaders in the field have been assembled who discuss both the practical and conceptual aspects of this rapidly growing field.




Organoborane Chemistry


Book Description

Organoborane Chemistry deals with the chemistry of organoboranes, with emphasis on compounds containing a carbon-boron bond. The structure and physical properties of organoboranes are discussed, along with the reactions of three-coordinate and four-coordinate organoboranes, organodiboranes, and other organopolyboranes such as organotetraboranes and organopentaborane compounds. Comprised of seven chapters, this book begins with an overview of multistep synthetic or degradative reactions involving organoboron compounds, along with the nomenclature for such compounds. The next chapter examines the structure and physical properties of organoboranes, with emphasis on boron-carbon bond lengths, electronic transitions, and molecular orbital calculations. Subsequent chapters focus on three-coordinate and four-coordinate organoboranes, together with their synthesis, reactions, and properties; hydroboration and dehydroboration of organodiboranes; and the synthesis, reactions, and physical properties of other organopolyboranes such as organotetraboranes, organopentaborane compounds, and organodecaborane compounds. The final chapter is devoted to cyclic boron-carbon systems and the applications of organoboron compounds. This monograph should be of interest to organic chemists.




Synthesis and Application of Organoboron Compounds


Book Description

The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics in pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors.




The Chemistry of Organoboron Compounds, 2 Volume Set


Book Description

The ultimate resource in organoboron chemistry Professor Mark Gandelman and his colleagues delve deeply into the theory, structure, analysis, synthesis, and reactions of organoboron chemistry in The Chemistry of Organoboron Compounds. Organoborons are used heavily as highly efficient reagents in many reactions, including cross-coupling and radical reactions. The highly regarded authors have tied together organic-chemical and physico-chemical knowledge usually unavailable from a single source. The book focuses on the use of completely biodegradable "green" reagents, as opposed to environmentally hazardous heavy metal catalysts. The Chemistry of Organoboron Compounds delivers comprehensive and complete information on: The behavior of organoboron compounds The use of organoboron compounds in organic synthesis The commercial applications of organoboron compounds As a volume in the celebrated Patai book series, The Chemistry of Organoboron Compounds includes all the features that readers of that series are used to enjoying, including a comprehensive index at the back of the book.




Organoboron Chemistry


Book Description







Contemporary Boron Chemistry


Book Description

The continued and evolving significance of boron chemistry to the wider chemical community is demonstrated by the international and interdisciplinary nature of the research reported in this book. Contemporary Boron Chemistry encompasses inorganic and organic compounds as well as polymers, solid-state materials, medicinal aspects and theoretical studies. Covering many areas of chemistry with boron at its centre, topics include applications to polyolefin catalysis, medicine, materials and polymers; boron cluster chemistry, including carboranes and metal-containing clusters; organic and inorganic chemistry of species containing only 1 or 2 boron atoms; and theoretical studies of boron-containing compounds. New materials with novel optical and electronic properties are also discussed. Comprehensive and up to date, graduates and researchers in a wide range of fields, particularly those in organometallic and organic chemistry and materials science, will welcome this book.




Boranes in Organic Chemistry


Book Description

The leading researcher in the uses of boranes in organic synthesis here reviews his work over the past thirty-five years, covering such areas as steric strains, the nonclassical ion problem, selective reductions, hydroboration, and the organoboranes as synthetic intermediates. But more than an exposition of enormous accomplishment, the book is a scientific autobiography that will provide chemists with historical perspective on their profession. The author's detailed narrative of his own research experiences not only adds to the understanding of the present state of the study of boranes, but will serve as a stimulus to imaginative research in the future.




Organoboron Chemistry


Book Description




Synthesis of Functionalized Organoboron Compounds Through Copper(I) Catalysis


Book Description

This book describes state-of-the-art borylation chemistry using copper(I) catalysis. Enantioselective reactions are included to afford a variety of functionalized, complex organoboronate esters, which will find wide application in asymmetric synthesis, drug discovery, and material science. Organoboron compounds are recognized as useful reagents in organic synthesis; therefore, great effort has been devoted to the development of a simple, mild, and efficient method for their preparation in the past several years. However, the synthesis of functionalized organoboron compounds remains a challenging issue because known reactions often require the use of highly reactive organometallic carbon nucleophiles. This book focuses on conceptually new, formal nucleophilic copper(I)-catalyzed borylation reactions with diboron compounds that show high selectivity and excellent functional group compatibility. Theoretical studies based on density functional theory calculations to understand the reaction mechanisms have also been described. Advances in this novel borylation chemistry will allow the rapid and efficient synthesis of complex molecules with potentially interesting properties in combination with the boron functionalization process.