Strategies and Tactics in Organic Synthesis


Book Description

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world. - Personal accounts of research in organic chemistry. - Written by internationally renowned scientists. - Details state of the art organic synthesis.




Strategies and Tactics in Organic Synthesis


Book Description

This is a unique account of the synthesis of organic molecules. All of the contributors are acknowledged experts in organic synthesis.




Organization and Tactics


Book Description




Strategies and Tactics in Organic Synthesis


Book Description

This account describes the total synthesis of the title compound, an antimitotic bicyclic peptide. A first-generation approach involving right-hand ring formation followed by left-hand ring annulation was unsuccessful but yielded several interesting observations. A revised strategy was devised in which left-hand ring synthesis would precede right-hand macrocycle construction. A suitably functionalized tryptophan derivative was prepared via phase transfer-catalyzed asymmetric alkylation and Larock heteroannulation. A Knoevenagel condensation–radical conjugate addition sequence fashioned the tryptophan–leucine cross-link, and macrolactamization furnished the left-hand ring. The concise, high-yielding nature of the route compensated for the low diastereoselectivity of the radical conjugate addition. Discovery of an NCS-promoted indole–imidazole oxidative coupling facilitated by proline benzyl ester enabled construction of the tryptophan–histidine cross-link, and right-hand macrolactamization delivered the target compound after deprotection. The chemical shifts of the imidazole hydrogens were strongly dependent on pH, temperature, and concentration. The title compound exhibited modest anticancer activity.







Attacking and Exploiting Modern Web Applications


Book Description

Master the art of web exploitation with real-world techniques on SAML, WordPress, IoT, ElectronJS, and Ethereum smart contracts Purchase of the print or Kindle book includes a free PDF eBook Key Features Learn how to detect vulnerabilities using source code, dynamic analysis, and decompiling binaries Find and exploit vulnerabilities such as SQL Injection, XSS, Command Injection, RCE, and Reentrancy Analyze real-world security incidents based on MITRE ATT&CK to understand the risk at the CISO level Book DescriptionWeb attacks and exploits pose an ongoing threat to the interconnected world. This comprehensive book explores the latest challenges in web application security, providing you with an in-depth understanding of hackers' methods and the practical knowledge and skills needed to effectively understand web attacks. The book starts by emphasizing the importance of mindset and toolset in conducting successful web attacks. You’ll then explore the methodologies and frameworks used in these attacks, and learn how to configure the environment using interception proxies, automate tasks with Bash and Python, and set up a research lab. As you advance through the book, you’ll discover how to attack the SAML authentication layer; attack front-facing web applications by learning WordPress and SQL injection, and exploit vulnerabilities in IoT devices, such as command injection, by going through three CTFs and learning about the discovery of seven CVEs. Each chapter analyzes confirmed cases of exploitation mapped with MITRE ATT&CK. You’ll also analyze attacks on Electron JavaScript-based applications, such as XSS and RCE, and the security challenges of auditing and exploiting Ethereum smart contracts written in Solidity. Finally, you’ll find out how to disclose vulnerabilities. By the end of this book, you’ll have enhanced your ability to find and exploit web vulnerabilities.What you will learn Understand the mindset, methodologies, and toolset needed to carry out web attacks Discover how SAML and SSO work and study their vulnerabilities Get to grips with WordPress and learn how to exploit SQL injection Find out how IoT devices work and exploit command injection Familiarize yourself with ElectronJS applications and transform an XSS to an RCE Discover how to audit Solidity’s Ethereum smart contracts Get the hang of decompiling, debugging, and instrumenting web applications Who this book is for This book is for anyone whose job role involves ensuring their organization's security – penetration testers and red teamers who want to deepen their knowledge of the current security challenges for web applications, developers and DevOps professionals who want to get into the mindset of an attacker; and security managers and CISOs looking to truly understand the impact and risk of web, IoT, and smart contracts. Basic knowledge of web technologies, as well as related protocols is a must.




Organization and Tactics


Book Description

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.




Tactics


Book Description

Tired of finding yourself flat-footed and intimidated in conversations? Want to increase your confidence and skill in discussions with family, friends, and coworkers? Gregory Koukl offers practical strategies to help you stay in the driver's seat as you maneuver comfortably and graciously in any conversation about your Christian convictions.




Game Theory and Machine Learning for Cyber Security


Book Description

GAME THEORY AND MACHINE LEARNING FOR CYBER SECURITY Move beyond the foundations of machine learning and game theory in cyber security to the latest research in this cutting-edge field In Game Theory and Machine Learning for Cyber Security, a team of expert security researchers delivers a collection of central research contributions from both machine learning and game theory applicable to cybersecurity. The distinguished editors have included resources that address open research questions in game theory and machine learning applied to cyber security systems and examine the strengths and limitations of current game theoretic models for cyber security. Readers will explore the vulnerabilities of traditional machine learning algorithms and how they can be mitigated in an adversarial machine learning approach. The book offers a comprehensive suite of solutions to a broad range of technical issues in applying game theory and machine learning to solve cyber security challenges. Beginning with an introduction to foundational concepts in game theory, machine learning, cyber security, and cyber deception, the editors provide readers with resources that discuss the latest in hypergames, behavioral game theory, adversarial machine learning, generative adversarial networks, and multi-agent reinforcement learning. Readers will also enjoy: A thorough introduction to game theory for cyber deception, including scalable algorithms for identifying stealthy attackers in a game theoretic framework, honeypot allocation over attack graphs, and behavioral games for cyber deception An exploration of game theory for cyber security, including actionable game-theoretic adversarial intervention detection against advanced persistent threats Practical discussions of adversarial machine learning for cyber security, including adversarial machine learning in 5G security and machine learning-driven fault injection in cyber-physical systems In-depth examinations of generative models for cyber security Perfect for researchers, students, and experts in the fields of computer science and engineering, Game Theory and Machine Learning for Cyber Security is also an indispensable resource for industry professionals, military personnel, researchers, faculty, and students with an interest in cyber security.