Eliminating the Public Health Problem of Hepatitis B and C in the United States


Book Description

Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.




Overcoming Barriers to Eliminate Hepatitis C, An Issue of Infectious Disease Clinics of North America


Book Description

The field of HCV has changed perhaps faster than any other field in medicine. The Guest Editors have strived to create an issue that is a state-of-the-art analysis of solutions to specific challenges faced in the United States and globally in implementing HCV elimination strategies. They believe that clinicians now have the tools and road maps needed to accomplish this goal. The clinical review articles in this issue accomplish that: Using Existing Health Care Infrastructure To Expand HCV Care; Creating A Reproducible Health Economic Model To Describe The Burden Of HCV And Cost Of Treatment In Any Country; The Best Uses Of Cost-Effectiveness Models In HCV; Increasing Access To HCV Care In Corrections; Cure As Prevention Strategies For HCV In People Who Inject Drugs; Australia Will Eliminate HCV – How It Works; New York Is The First State In The US To Develop An HCV Elimination Strategy; When HCV Diagnostics Are The Barrier To Care; Key Findings From The Checs HCV Cohort Study; Strategies To Reduce HCV Reinfection Rates In People Who Inject Drugs; Strategies To Reduce HCV Reinfection Rates In Men Who Have Sex With Other Men; The Value Of Curing HCV From A Payer’s Perspective; How To Expand Care Capacity In HCV; Strategies To Eliminate HCV In The HIV Coinfected Population; and The US Veteran’s Administration: Lessons Learned And Best Practices For HCV Elimination.




Overcoming Barriers to Eliminate Hepatitis C, an Issue of Infectious Disease Clinics of North America


Book Description

The field of HCV has changed perhaps faster than any other field in medicine. The Guest Editors have strived to create an issue that is a state-of-the-art analysis of solutions to specific challenges faced in the United States and globally in implementing HCV elimination strategies. They believe that clinicians now have the toolsand road maps needed to accomplish this goal. The clinical review articles in this issue accomplish that: Using Existing Health Care Infrastructure To Expand HCV Care; Creating A Reproducible Health Economic Model To Describe The Burden Of HCV And Cost Of Treatment In Any Country; The Best Uses Of Cost-Effectiveness Models In HCV; Increasing Access To HCV Care In Corrections; Cure As Prevention Strategies For HCV In People Who Inject Drugs; Australia Will Eliminate HCV - How It Works; New York Is The First State In The US To Develop An HCV Elimination Strategy;? When HCV Diagnostics Are The Barrier To Care; Key Findings From The Checs HCV Cohort Study; Strategies To Reduce HCV Reinfection Rates In People Who Inject Drugs; Strategies To Reduce HCV Reinfection Rates In Men Who Have Sex With Other Men; The Value Of Curing HCV From A Payer's Perspective; How To Expand Care Capacity In HCV; Strategies To Eliminate HCV In The HIV Coinfected Population; and The US Veteran's Administration: Lessons Learned And Best Practices For HCV Elimination.




Hepatitis C: Care and Treatment


Book Description

This volume provides the reader with a detailed overview of the current state-of-the art approach of Hepatitis C management. It reviews the course of action in handling of chronic Hepatitis C patients with various HCV genotypes and treats special cases such as acute hepatitis, transplant and renal patients as well as people who inject drugs. The two volume work on Hepatitis C introduces to the topic by reviewing virology, diagnosis, epidemiology, prevention, management and elimination of HCV. The book provides a valuable source at full length for researchers and clinicians working on Hepatitis C.




Disease Control Priorities, Third Edition (Volume 6)


Book Description

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.




Infections in Children, An Issue of Infectious Disease Clinics of North America, E-Book


Book Description

The Guest Editors have compiled a comprehensive issue that addresses the current clinical diagnosis, treatment,and management of infections in children. Top authors in their field have written review articles on the following topics: Update on Varicella Zoster Virus in Children; Emerging Respiratory Viruses in Children; Bronchiolitis in Children; Antimicrobial resistance in pediatrics in Children; New updates in influenza vaccination in Children; Changing epidemiology of CAP in Children; Zika Virus in Children; Ebola Virus in Children; Infections in Children on biologics; New rapid diagnostics in Children; Infections in HSCT Children; Changing epidemiology of H. influenzae infections in Children; Norovirus in Children; PEP in children; Syphilis in Children; Encephalitis in Children; and Malaria in Children. Infectious disease physicians will have the most current and up-to-date best practice information in their field.




Updates in Tropical Medicine, An Issue of Infectious Disease Clinics of North America


Book Description

With consultation of Dr. Helen Boucher, Drs. Libman and Younsouni have put together an issue that provides current updates on a wide range of topics in tropical medicine. They have enlisted top experts from around the world to offer their expertise on state-of-the-art diagnosis, treatment, and management. The clinical reviews in this issue are devoted to: Tropical Diseases: Definition, Geographic Distribution, Transmission, and Classification; Venomous Bites, Stings, and Poisoning; What’s New in Management in the Management of Malaria; Human African Trypanosomiasis; American Trypanosomiasis; Leishmaniasis – Recent Developments in the Diagnosis and Management; Enteric Infections: New Paradigms for Causality and Key Pathogens; Enteric Infections: New Paradigms for Morbidity; Strongyloides, the Neglected NTD: Current Concepts for Screening, Diagnosis, and Treatment; Cysticercosis: State-of the Art Management; Arboviruses and Viral Hemorrhagic Fevers; Laboratory Diagnosis of Tropical Infections; Diagnostics During Public Health Emergencies: Lessons from Ebola and Zika; Antimicrobial Resistance; Migration Medicine in 2018; and Richettsiosis: Practical Update. Readers will come away with the information they need to make clinical decisions with confidence.




Infections in Older Adults, An Issue of Infectious Disease Clinics of North America


Book Description

With the expanding aging population in both the United States and worldwide, health issues associated with aging are major personal and public health concerns. Although cardiovascular diseases, cancers, strokes, dementia, pulmonary disease, and diabetes mellitus are listed as major causes of death in older adults, in many instances the final cause of demise is complications associated with infections. Dr. Jump and Dr. Canady have assembled top authors to present the current clinical knowledge on the following topics: Urinary Tract Infections; Clostrdium difficile; Wounds/SSTI; Influenza; Other Respiratory Viruses; HIV; Antimicrobial Stewardship for Older Adults; Antibiotics at the End of Life; Sepsis in Older Adults; Antimicrobial Therapy in Older Adults; Norovirus/Viral outbreaks; and Bone and Joint Infections. Readers should have a solid understanding of the current clinical information needed to effectively manage infections in older adults.




Device-Associated Infections, An Issue of Infectious Disease Clinics of North America


Book Description

In collaboration with Consulting Editor, Dr. Helen Boucher, Dr. Vivian Chu has created an issue that provides current clinical updates on device-associated infections. Authors are represented by experts across the world, who have contributed clinical reviews on the following topics: Intravascular Catheter-Related Bloodstream Infections; Vascular Graft Infections; Cardiovascular Implantable Electronic Device-Associated Infections; Left Ventricular Device-Associated Infections; Urinary Catheter-Associated Infections; Prosthetic Joint Infections; Neurosurgical Device-Related Infections; Breast Implant Infections; Cochlear Implant Infections; Gastrointestinal Scope-Related Infections; Understanding Biofilms and Novel Approaches to the Diagnosis, Prevention, and Treatment of Medical Device-Associated infections; and Infections of Hemodialysis Access Devices. Readers will come away with the information they need to make informed clinical decisions that improve patient outcomes.




Acute Liver Failure, An Issue of Clinics in Liver Disease


Book Description

Dr. Pyrsopoulos has assembled the top authors in the field to provide current reviews on acute liver failure, to be the first time this topic is addressed in one volume. Topics are devoted to Classification and Epidemiologic Aspects of Acute Liver Failure; Acute Liver Failure: Mechanisms of disease and multi-systemic involvement; The Pathology of Acute Liver Failure; Liver Regeneration in the Acute Liver Failure Patient; Viral Hepatitis and Acute Liver Failure: Still a Problem; Drug- induced Liver Injury and Acute Liver Failure; Acetaminophen and Acute Liver Failure; Non-Viral Or Drug-Induced Etiologies of Acute Liver Failure; The Clinical Spectrum and Manifestations of Acute Liver Failure; Non ICU Management of Acute Liver Failure; Management of Acute Liver Failure in the ICU Setting; Prognostic Models of Acute Liver Failure; The Role of Liver Transplantation in Acute Liver Failure; and Future Approaches and Therapeutic Modalities for Acute Liver Failure. Readers will come away with a current point of view about how to approach and manage the patient with acute liver failure.