Pain Measurement in Man


Book Description




Handbook of Pain and Aging


Book Description

From time to time, professional journals and edited volumes devote some of their pages to considerations of pain and aging as they occur among the aged in different cultures and populations. One starts from several reasonable assumptions, among them that aging per se is not a disease process, yet the risk and frequency of disease processes increase with ongoing years. The physical body's functioning and ability to restore all forms of damage and insult slow down, the immune system becomes compromised, and the slow-growing pathologies reach their critical mass in the later years. The psychological body also becomes weaker, with unfulfilled promises and expectations, and with tragedies that visit individuals and families, and the prospect that whatever worlds remain to be conquered will most certainly not be met with success in the rapidly passing days and years that can only culminate in death. Despair and depression coupled with infirmity and sensory and! or motor inefficiency aggravate both the threshold and the tolerance for discomfort and synergistically collaborate to perpetuate a vicious cycle in which the one may mask the other. Although the clinician is armed with the latest advances in medicine and phar macology, significant improvement continues to elude her or him. The geriatric specialist, all too familiar with such realities, usually can offer little else than a hortative to "learn to live with it," but the powers and effectiveness of learning itself have declined.




Clinical Measurement in Drug Evaluation


Book Description

Clinical measurement of the therapeutic and adverse effects of a drug is an important part of drug evaluation and registration. This volume presents full coverage of the principles and practice of the measurement of drug effects in humans and its role in the evaluation and development of new drugs. Clinical interpretation and relevance of data, as well as the acceptability and accuracy of methodology are emphasized together with the special problems of the cardiovascular system and the central nervous system. Contributions are from an international team of scientists and clinicians from both academia and industry. Clinical Measurement in Drug Evaluation will be useful for clinical and research scientists, research-based pharmacologists, and the pharmaceutical industry.




Sex, Gender, and Pain


Book Description

Research is finally acknowledging that sex differences in pain perception are experimental opportunities rather than obstacles. For the International Association for the Study of Pain, 32 specialists in 18 contributions explore basic biopsychosocial considerations for sex, gender, and pain research; and sex-related differences in experimental pain responses, and in clinical conditions (e.g. headache disorders, fibromyalgia, irritable bowel syndrome). The concluding paper by K. Berkley (neuroscience, Florida State U., Tallahassee) proposes a developmental lifespan framework for the complex issue of whether there is characteristic female pain as vs. male pain. Fillingim is in the U. of Florida's College of Dentistry. For those keeping count of such matters, there is about a 40:60 percent ratio of female to male authors. Annotation copyrighted by Book News, Inc., Portland, OR.







Advances and Challenges in Pain Measurement


Book Description

Lord Kelvin (William Thompson) “To measure is to know.” “If you cannot measure it, you cannot improve it.” Pain has proven elusive to definitive measurement in research and clinical settings. While the experience is familiar to virtually everyone, it also is recognized as complex and multidimensional. Critiques of the field advise that pain is often unrecognized, inadequately assessed and underestimated. Unidimensional scales relying upon self-report are commonly used both clinically and in research settings, but they are vulnerable to presentation bias and they fail to capture the complexity of this multidimensional phenomenon. In consequence, there has been considerable interest and effort devoted to the generation of measures capable to capturing the experience for both research and clinical purposes. Both behavioral and physiological approaches have been pursued. Verbal behavior is represented by self-report scales that vary in dimensionality, typically seeking to represent sensory, affective and cognitive features of the experience. The status of self-report scales as the gold standard for pain assessment has been questioned. Nonverbal measures seek to capture behavioral activity ranging from facial expression through limb movements and gestures to posture. Physiological measures are similarly wide-ranging capitalizing on recent developments in brain imaging and novel approaches to autonomic regulation. There also are efforts to fuse behavioral and physiological measures as a means of capturing the complexity of pain. This series of papers seeks to represent the most recent conceptual and empirical advances in the important and rapidly advancing field of pain assessment and measurement. We invite both reviews of the literature and research investigations advancing the field.







New Frontiers in Human–Robot Interaction


Book Description

Human–Robot Interaction (HRI) considers how people can interact with robots in order to enable robots to best interact with people. HRI presents many challenges with solutions requiring a unique combination of skills from many fields, including computer science, artificial intelligence, social sciences, ethology and engineering. We have specifically aimed this work to appeal to such a multi-disciplinary audience. This volume presents new and exciting material from HRI researchers who discuss research at the frontiers of HRI. The chapters address the human aspects of interaction, such as how a robot may understand, provide feedback and act as a social being in interaction with a human, to experimental studies and field implementations of human–robot collaboration ranging from joint action, robots practically and safely helping people in real world situations, robots helping people via rehabilitation and robots acquiring concepts from communication. This volume reflects current trends in this exciting research field.




Early Phase Drug Evaluation in Man


Book Description

Early Phase Drug Evaluation in Man is a comprehensive, practical guide that covers pre-clinical information relevant to early human studies, including pharmaceutical, metabolic, toxicological, and regulatory aspects, as well as the general considerations relevant to all early human studies. Each major therapeutic area is considered by class of activity of drug. The chapters describe what measurements of drug activity are available in healthy human subjects and in patients, how to make the measurements, their value and their limitations. The contributors have been drawn internationally from the pharmaceutical industry and academia. Early Phase Drug Evaluation in Man will provide an important reference guide for industry and academic professionals involved in the development of new drugs.




Multimethod Assessment of Chronic Pain


Book Description

Multimethod Assessment of Chronic Pain is a guidebook diagnosing chronic pain. The title presents the framework and methods for pain assessment, which serves as the basis for the systematic treatment of chronic pain. The text first covers the multiple contexts of chronic pain, and then proceeds to tackling the biomedical context. Next, the selection talks about the subjective pain experience, along with the measures of psychological status. Chapter 5 discusses the biophysical measurement, while Chapter 6 covers the behavioral observation methods. The text also details clinical pain interview and the selection and integration of pain measures. The book will be of great use to students of therapeutics related degrees. The text will also serve health professionals as a reference.