Book Description

This report presents a cost analysis of Paracetamol production from 4-nitrochlorobenzene, sodium hydroxide, hydrogen and acetic anhydride. In the process, 4-nitrochlorobenzene reacts with sodium hydroxide producing para nitrol phenol (PNP). The PNP is then subjected to reduction, producing para amino phenol (PAP). The PAP is then acetylated to produce crude Paracetamol, which is further purified. This report was developed based essentially on the following reference(s): (1) US Patent 2008/0045756, issued to Rhodia Chimie in 2008 (2) US Patent 3079435 issued to Abbott Laboratories in 1963 Keywords: Acetaminophen, APAP, Acamol, Abensanil, para Nitrochlorobenzene, PNCB