Parallels Between Cognitive and Motor Deficits in Parkinson's Disease
Author : Sheryl Shook
Publisher :
Page : 254 pages
File Size : 13,82 MB
Release : 2002
Category :
ISBN :
Animal Models of Cognitive Impairment
Author : Edward D Levin
Publisher : CRC Press
Page : 400 pages
File Size : 28,87 MB
Release : 2019-08-30
Category :
ISBN : 9780367390679
Book Description
The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer's, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.
Cognition in Parkinson's Disease
Author :
Publisher : Elsevier
Page : 490 pages
File Size : 46,36 MB
Release : 2022-03-02
Category : Psychology
ISBN : 0323901654
Book Description
Cognition in Parkinson's Disease, Volume 269 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cognition in Prodromal Parkinson's disease, The epidemiology of cognitive function in Parkinson's disease, Real-life consequences of cognitive dysfunction in Parkinson's disease, Animal models of cognition in Parkinson's disease, Functional neuroanatomy of cognition in Parkinson's disease, Neuroimaging approaches to cognition in Parkinson's disease, Cognitive dysfunction and neuropsychiatric aspects of Parkinson's disease, Neuropsychology of Parkinson's disease, Cholinergic Systems, Attentional-Motor Integration, and Cognitive Control in Parkinson Disease, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Progress in Brain Research series - Updated release includes the latest information on Cognition in Parkinson's Disease
The Cognitive and Motor Deficits of Parkinson's Disease
Author : Jeremy Gauntlett-Gilbert
Publisher :
Page : 278 pages
File Size : 32,38 MB
Release : 1999
Category :
ISBN :
Book Description
Clinical Nuclear Medicine in Neurology
Author : Andrea Varrone
Publisher : Springer Nature
Page : 180 pages
File Size : 10,2 MB
Release : 2021-11-10
Category : Medical
ISBN : 3030835987
Book Description
This book gathers a collection of cases with challenging diagnoses, in which nuclear medicine examinations have been particularly helpful in terms of the final diagnosis or follow-up. The cases presented chiefly involve patients with neurodegenerative disorders, epilepsy and brain tumors. The book is intended for nuclear medicine specialists as well as clinicians, offering essential guidance on the interpretation of neurology cases in the clinical setting, particularly with regard to correctly interpreting diagnostic imaging procedures. The authors were selected from the members of the Neuroimaging Committee of the EANM and have extensive experience as clinicians and teachers within the Nuclear Medicine Community.
Etiology of Parkinson's Disease
Author : Jonas H. Ellenberg
Publisher : CRC Press
Page : 600 pages
File Size : 40,79 MB
Release : 1995-03-01
Category : Medical
ISBN : 9780824788230
Book Description
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Standardized Mini-mental State Examination
Author :
Publisher :
Page : 28 pages
File Size : 29,90 MB
Release : 1999
Category : Cognition
ISBN : 9780969464570
Book Description
The Folstein mini-mental state examination (MMSE) is the most widely used screening test of cognition in older adults. The Standardized mini-mental state examination (SMMSE) provides clear, explicit administration and scoring guidelines.
Dementia with Lewy Bodies
Author : John O'Brien
Publisher : CRC Press
Page : 286 pages
File Size : 20,16 MB
Release : 2005-11-29
Category : Medical
ISBN : 0203313909
Book Description
Filling a noticeable gap in the market for a new text solely focused on Dementia with Lewy Bodies, this book discusses cutting-edge topics covering the condition from diagnosis to management, as well as what is known about the neurobiological changes involved. With huge progress having been made over the last decade in terms of the disorder
Cognitive Deficits in Parkinson's Disease are Associated with Neuronal Dysfunction and Not White Matter Lesions
Author : Nils Schröter
Publisher :
Page : 0 pages
File Size : 29,41 MB
Release : 2023
Category :
ISBN :
Book Description
Abstract: Background Cognitive deficits considerably contribute to the patient's burden in Parkinson's disease (PD). While cognitive decline is linked to neuronal dysfunction, the additional role of white matter lesions (WML) is discussed controversially. Objective To investigate the influence of WML, in comparison to neuronal dysfunction, on cognitive deficits in PD. Methods We prospectively recruited patients with PD who underwent neuropsychological assessment using the Mattis Dementia Rating Scale 2 (DRS-2) or Parkinson Neuropsychometric Dementia Assessment (PANDA) and both MRI and PET with [18F]fluorodeoxyglucose (FDG). WML-load and PD cognition-related covariance pattern (PDCP) as a measure of neuronal dysfunction were read out. Relationship between cognitive performance and rank-transformed WML was analyzed with linear regression, controlling for the patients' age. PDCP subject scores were investigated likewise and in a second step adjusting for age and WML load. Results Inclusion criteria were met by 76 patients with a mean (± SD) age of 63.5 ± 9.0 years and disease duration of 10.7 ± 5.4 years. Neuropsychological testing revealed front executive and parietal deficits and a median DRS-2 score of 137 (range 119-144)/144 and PANDA score of 22 (range 3-30)/30. No association between WML and cognition was observed, whereas PDCP subject scores showed a trend-level negative correlation with the DRS-2 (P = 0.060) as well as a negative correlation with PANDA (P = 0.049) which persisted also after additional correction for WML (P = 0.039). Conclusion The present study indicates that microangiopathic WML do not have a relevant impact on neurocognitive performance in PD whereas neuronal dysfunction does
Non-Motor Symptoms of Parkinson's Disease
Author : K. Ray Chaudhuri
Publisher : Oxford University Press, USA
Page : 517 pages
File Size : 17,30 MB
Release : 2014
Category : Medical
ISBN : 0199684243
Book Description
Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.
