Pathologic Conditions of the Human Nervous and Muscular Systems Associated with Mutant Chaperones: Molecular and Mechanistic Aspects


Book Description

This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.







Stress: Immunology and Inflammation


Book Description

Stress: Immunology and Inflammation, Volume Five in the Handbook of Stress series, covers the influence physiologic stress has on immunity, immunology and inflammation. It provides a quick orientation to the subject for research, in clinic use, and in everyday life. Integrated closely with new behavioral findings and with relevance to human conditions, the concepts and data in this volume offer readers cutting-edge information. It will be of prime interest to neuroscientists, clinicians, researchers, academics, and students in Neuroendocrinology, Neuroscience, Biomedicine, Immunology, Endocrinology, Psychology, Psychiatry and some aspects of the Social Sciences. The effect of stress on our emotional and physical health can be devastating. There have been significant advances in our understanding of the influence stress has on inflammation in the human body and also our immunity to various afflictions. - Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge - Richly illustrated with explanatory figures and tables - Each chapter includes a boxed "Key points call out section - The volume is fully indexed - All chapters are electronically available via ScienceDirect - Affordably priced, self-contained volume for readers specifically interested in the interaction between stress inflammation and the immune response, obviating the need to purchase the whole Handbook series




Tandem Repeat Polymorphisms


Book Description

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease.




Disorders of Voluntary Muscle


Book Description

Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.




Etiology of Parkinson's Disease


Book Description

This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.




The Molecular and Cellular Basis of Neurodegenerative Diseases


Book Description

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. - Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features - Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration - Details features, advantages and limitations of animal models, as well as prospects for therapeutic development - Authored by internationally recognized leaders in the field - Includes illustrations that help clarify and consolidate complex concepts




In-cell NMR Spectroscopy


Book Description

In-cell NMR spectroscopy is a relatively new field. Despite its short history, recent in-cell NMR-related publications in major journals indicate that this method is receiving significant general attention. This book provides the first informative work specifically focused on in-cell NMR. It details the historical background of in-cell NMR, host cells for in-cell NMR studies, methods for in-cell biological techniques and NMR spectroscopy, applications, and future perspectives. Researchers in biochemistry, biophysics, molecular biology, cell biology, structural biology as well as NMR analysts interested in biological applications will all find this book valuable reading.




Handbook of Models for Human Aging


Book Description

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. - Utilizes a multidisciplinary approach - Shows tricks and approaches not available in primary publications - First volume of its kind to combine both methods of study for human aging and animal models - Over 200 illustrations




The Endothelium


Book Description

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References