Transplant Pathology


Book Description




Pathology of Solid Organ Transplantation


Book Description

Because of the progress in diagnostic transplantation pathology interpretation of transplant biopsies is increasingly becoming an attractive field for general surgical pathologists. The book focuses on the pathology of transplantation in the following organs: kidney, liver, lungs, heart, pancreas and small intestine. An introductory section addresses common entities that may complicate all transplant recipients such as infections, post-transplant lymphoproliferative disease and graft versus host disease, followed by 6 sections with detailed manifestations of rejection in each organ. This comprehensive, well-illustrated book serves the needs and meets the requirements of pathologists in training and those practicing in centers with limited volume of transplant biopsies in daily practice.




Practical Atlas of Transplant Pathology


Book Description

This atlas describes and illustrates the pathology of solid organ transplants and includes chapters covering transplant pathology of the kidney, lung, heart, liver, pancreas, small bowel and limbs. Each of these chapters briefly reviews the latest rejection classifications for each organ system with explanatory notes highlighting diagnostic criteria, and tables listing entities in the differential diagnosis. Included with each chapter are images demonstrating the pathology of the most common and important diseases, especially patterns of organ rejection and related entities or mimickers. Examples of classic disease processes are provided, as well as atypical presentations that may highlight and prevent diagnostic pitfalls. A comprehensive explanation of the immunogenetics of transplant rejection is included, enabling the general pathologist to become familiar with the most important aspects of serologic testing in this patient population. A review of post-transplant lymphoproliferative diseases is also provided. Practical Atlas of Transplant Pathology is aimed at both general and expert pathologists who encounter transplant pathology specimens in their practice.




Pathology of Transplantation


Book Description

Many pathologists find the interpretation of biopsies and other surgical specimens from solid organ, stem cell and bone marrow transplants challenging. Pathology of Transplantation provides a practical structured and logical approach to the diagnostic interpretation of the range of specimens from patients with solid organ, stem cell and bone marrow transplants, including the assessment of native and donor organs, with emphasis on resolution of pathological and clinico-pathological differential diagnoses including the diverse forms of rejection, recurrent and de novo diseases, drug-induced alterations, infections and other pathologies relevant to the system or tissue. In addition, this provides information on some of the critical clinical consequences of pathological diagnoses and guidelines for interaction and effective communication with transplant clinicians thereby ensuring the best possible care to patients with transplants. Pathology of Transplantation provides a relatively simple but diagnostically comprehensive and practical book that the pathologist will keep on hand and pick up to rapidly find answers in daily practice of transplantation pathology.




Transplantation Pathology


Book Description

General pathologists see many biopsies from transplanted organs but few are in large enough centres so that this forms the bulk of their work. The book describes the changes which can be observed in transplantation in all of the major organ systems that are routinely transplanted and there are accounts of the pathology of infections and of the immunological difficulties that are faced by these patients. The volume will be a valuable guide for those who wish to braoden their knowledge in this field.




Solid Organ Transplantation Pathology


Book Description

This text provides the reader with information and pertinent references on important aspects of solid organ transplant pathology. Diagrams are used to clarify concepts and nomenclature. Illustrations of light microscopic features of the changing classification of allograft rejection in various organ sites are also provided. Topics covered include the actions and interactions of immunosuppressive drugs, pathology of cardiac, renal, liver, and heart-lung transplant rejection, and much more.




Diagnostic Pathology: Transplant Pathology E-Book


Book Description

Part of the highly regarded Diagnostic Pathology series, this updated volume by Drs. Anthony Chang and Robert B. Colvin is an ideal point-of-care reference to guide you through the complex realm of transplant pathology. Concise, focused chapters, supported by tables, diagrams, radiographs, and photographs, provide essential information to keep you up to date with the impact of new viral infections, updates from the Banff Allograft Conference, new information on next-generation sequencing, and much more. More than 20 experts present their collective knowledge to assist you with different aspects of transplant pathology, including rare issues such as the impact of new viral infections (e.g., the Zika virus on transplant patients who are immunosuppressed) Packed with high-quality images that provide examples and potential pitfalls of diagnostic lesions that you are likely to encounter Time-saving reference features include bulleted text, tables of diagnostic criteria, annotated images, and an extensive index Thoroughly updated content keeps you current with all aspects of transplant immunology and pathology, guiding you expertly through diagnostic challenges such as donor disease, surgical complications, allograft rejection, drug toxicity, opportunistic infections, and/or recurrent or de novo diseases that can occur simultaneously or at different times New Banff classifications are integrated into all chapters, covering pathology of all clinical organ transplants, including kidney, heart, lung, liver, pancreas, small bowel, and vascularized composite allografts as well as bone marrow allografts New coverage includes next-generation sequencing, which is quickly becoming the standard for HLA testing, as well as new drugs that are in clinical trials for the treatment of antibody-mediated rejection







Diagnostic Pathology: Transplant Pathology - E-BOOK


Book Description

This volume in the Diagnostic Pathology series is an ideal point-of-care resource for practitioners at all levels of experience and training. Covering the full range of solid organ transplantation (SOT) of the kidney, liver, heart, lung, pancreas, intestine, and more, it provides a current understanding of transplant immunology and pathology to help ensure accurate diagnosis for optimal clinical management. Richly illustrated and easy to use, Diagnostic Pathology: Transplant Pathology, third edition, is a visually stunning, one-stop reference for practicing pathologists, transplant practitioners, and students of organ transplantation. Covers all areas of transplant pathology, incorporating the collective knowledge and experience from a team of transplant pathology experts with the latest updates from the 2022 Banff classification Groups content by specific organ transplant, including kidney, liver, heart, lung, intestine, pancreas, and vascularized composite allotransplantation Features sweeping updates throughout, including new chapters on transplant immunology that cover chronic viral infections and the immune response, immune manipulation and accommodation, and graft-vs.-host disease Contains a new chapter on islet cell transplantation and new, detailed information on xenotransplantation—specifically kidney xenograft Covers advances in vascularized composite allografts (hands, face, uterus, phallus) transplantation Features more than 1,500 superb images, including histology, gross pathology, full-color illustrations, and radiologic images Employs consistently templated chapters, bulleted content, key facts, annotated images, and an extensive index for quick, expert reference at the point of care Any additional digital ancillary content may publish up to 6 weeks following the publication date




The Brain-Dead Organ Donor


Book Description

Addressing all aspects of brain death and thoroughly detailing how a potential organ donor should be maintained to ensure maximum use of the organs and cells, The Brain-Dead Organ Donor: Pathophysiology and Management is a landmark addition to the literature. This first-of-its-kind, multidisciplinary volume will be of interest to a large section of the medical community. The first section of the book reviews the historical, medical, legal, and ethical aspects of brain death. That is followed by two chapters on the pathophysiology of brain death as investigated in small and large animal models. This includes a review of the many hormonal changes, including the neuroendocrine- adrenergic ‘storm’, that takes place during and following the induction of brain death, and how they impact metabolism. The next section of the book reviews various effects of brain death, namely its impact on thyroid function, the inflammatory response that develops, and those relating to innate immunity. The chapters relating to assessment and management of potential organ donors will be of interest to a very large group of transplant surgeons and physicians as well as critical care and neurocritical care physicians and nurses. Neurologists, endocrinologists, neurosurgeons, and pathologists will also be interested, especially in the more basic science sections on various aspects of brain-death and hormonal therapy. Organ procurement organizations and transplant coordinators worldwide will also be interested in this title. Other chapters will be of interest to medical historians, medico-legal experts, and ethicists.