Author : Christopher Dutton
Publisher : CRC Press
Page : 310 pages
File Size : 14,45 MB
Release : 2001-12-04
Category : Science
ISBN : 9780203910801
This reference summarizes the latest research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications of these compounds in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct anti-bacterial action and as part of the adaptive immune resp
Author : Steeve Giguère
Publisher : John Wiley & Sons
Page : 49 pages
File Size : 18,93 MB
Release : 2013-07-25
Category : Medical
ISBN : 111867507X
The Fifth Edition of Antimicrobial Therapy in Veterinary Medicine, the most comprehensive reference available on veterinary antimicrobial drug use, has been thoroughly revised and updated to reflect the rapid advancements in the field of antimicrobial therapy. Encompassing all aspects of antimicrobial drug use in animals, the book provides detailed coverage of virtually all types of antimicrobials relevant to animal health. Now with a new chapter on antimicrobial therapy in zoo animals, Antimicrobial Therapy in Veterinary Medicine offers a wealth of invaluable information for appropriately prescribing antimicrobial therapies and shaping public policy. Divided into four sections covering general principles of antimicrobial therapy, classes of antimicrobial agents, special considerations, and antimicrobial drug use in multiple animal species, the text is enhanced by tables, diagrams, and photos. Antimicrobial Therapy in Veterinary Medicine is an essential resource for anyone concerned with the appropriate use of antimicrobial drugs, including veterinary practitioners, students, public health veterinarians, and industry and research scientists.
Author : Djamel Drider
Publisher : Springer Science & Business Media
Page : 451 pages
File Size : 14,27 MB
Release : 2011-03-08
Category : Science
ISBN : 1441976922
The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products. Antimicrobial peptides stand as potentially great alternatives to current antibiotics, and most research in this newly-created area has been published in journals and other periodicals. It is the editors’ opinion that it is timely to sum up the most important achievements in the field and provide the scientific community in a reference book. The goals of this project include illustrating the achievements made so far, debating the state of the art, and drawing new perspectives.
Author : Katsumi Matsuzaki
Publisher : Springer
Page : 300 pages
File Size : 10,75 MB
Release : 2019-04-12
Category : Medical
ISBN : 9811335885
This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.
Author : Christopher Dutton
Publisher : CRC Press
Page : 230 pages
File Size : 30,60 MB
Release : 2001-12-04
Category : Science
ISBN : 0824745256
This reference summarizes the latest research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications of these compounds in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct anti-bacterial action and as part of the adaptive immune response. Peptide Antibiotics discusses these unique compounds and their many and exciting applications, including: the distribution and classification of diverse antimicrobial peptides throughout nature the role in host defense of mucosal surface peptide antibiotics such as defensins and cathepsins the biosynthesis of lanthionine-containing antibiotics including nisin, epidermin, and mersacidin the genetic basis determining the production of bacterial peptide antibiotics the potential commercial use of magainin, nisin, and lacticin peptides as anti-infective agents the use of nisin as a commercial food preservative With contributions from 19 world-renowned experts in the field, Peptide Antibiotics is an indispensable source of information for pharmaceutical scientists, medicinal and organic chemists and biochemists, microbiologists, infectious disease specialists, molecular biologists, and upper-level undergraduate and graduate students in these disciplines.
Author : Anton Ficai
Publisher : Elsevier
Page : 724 pages
File Size : 32,52 MB
Release : 2017-05-29
Category : Science
ISBN : 0323461514
Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. - Shows how nanoantibiotics can be used to more effectively treat disease - Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs - Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area
Author : Loriano Ballarin
Publisher : Academic Press
Page : 326 pages
File Size : 34,95 MB
Release : 2016-04-08
Category : Medical
ISBN : 0128032537
Lessons in Immunity: From Single-cell Organisms to Mammals stems from the activity of the Italian Association of Developmental and Comparative Immunobiology (IADCI), represented by the editors. This book is presented as a series of short overviews that report on the current state of various relevant fields of immunobiology from an evolutionary perspective. The overviews are written by authors directly involved in the research, and most are members of the IADCI or have otherwise been involved in the related research for their respective overview. This publication offers scientists and teachers an easy and updated reference tool. - Provides simple and updated reviews on the immunobiology of a wide spectrum of organisms, considered in an evolutionary context - Focuses on both cells and humoral components of a variety of non-classical model organisms - Offers in a single volume many contributions which can help with understanding the evolution of immune responses and the main adaptations in animal phyla - Presents a valuable holistic cross-sectional approach for teaching immunology and its applications
Author : Ranjita Shegokar
Publisher : William Andrew
Page : 291 pages
File Size : 47,93 MB
Release : 2018-05-17
Category : Technology & Engineering
ISBN : 0323401139
Emerging Nanotechnologies in Immunology aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular, and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure.The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular, and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body.The contributors addresses a representative set of the broad spectrum of nanopharmaceuticals currently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use. - Provides the reader with a thorough knowledge of the safety aspects of nanopharmaceuticals which are currently under research - Focuses on the characterization and quantification of the nanopharmaceuticals - Allows readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects - Includes an overview of regulatory aspects related to the R&D of nanopharmaceuticals
Author : Richard M. Epand
Publisher : CRC Press
Page : 422 pages
File Size : 48,4 MB
Release : 1993-07-09
Category : Medical
ISBN : 9780849349263
The Amphipathic Helix is a comprehensive volume discussing amphipathic helices in systems as diverse as serum lipoproteins, lung surfactant, cytotoxic peptides, ion channels, mitochondrial targeting, peptide hormones, G proteins, T-cell recognition, DNA binding proteins, and antifreeze proteins. The book also includes general introductory material that defines amphipathic helices, discusses methods to identify amphipathic helical segments from the amino acid sequence of a protein, illustrates how amphipathic helices can be used in the de novo design of peptide and protein structures, and describes how these helices stabilize protein structures. There is also a section on techniques to determine helix orientation in a membrane environment using polarized attenuated total reflection infrared spectroscopy or solid state NMR spectroscopy. Recent developments on all these topics have been discussed by leading experts in this reference for researchers and students in biochemistry, biophysics, and pharmacology.
Author : Kateryna Kon
Publisher : Academic Press
Page : 340 pages
File Size : 14,58 MB
Release : 2017-04-25
Category : Science
ISBN : 0128110937
The Microbiology of Skin, Soft Tissue, Bone and Joint Infections: Volume 2 discusses modern approaches in diagnosis, treatment, and prophylaxis of skin, soft tissue, bone, and joint infections. The volume has been divided into three sections. The first section includes chapters on diagnosis, treatment, and prophylaxis of skin and soft tissue infections. It discusses antimicrobial and surgical treatment of wounds, diabetic foot, and different soft tissue infections. Ten chapters are devoted to cutaneous and musculoskeletal infections in special groups of patients, which have their own specificity, i.e. in pediatric and HIV-infected patients. Together with chapters on commonly present diseases, there are chapters which discuss interesting but not well studied pathologies (natal cleft pilonidal sinus) and pathogens (Malassezia and Shewanella spp.). The second section reviews etiology, pathogenesis, diagnosis and treatment of bone and joint infections, mainly osteomyelitis and prosthetic joint infections. Also, one chapter in this section discusses a newly emerging bacterial pathogen that causes skeletal infections, Kingella kingae. The third section incorporates alternative and new approaches—such as nanotechnology, ultrasound, novel delivery approaches and phyto-derived medicines—to the treatment and prophylaxis of skin, soft tissue, bone, and joint infections. - Encompasses a broad range of skin, soft tissue, bone, and joint infections, including questions of etiology, pathogenesis, diagnosis, prognosis, treatment, and prophylaxis - Written by highly professional and eminent surgeons, microbiologists, and infectious disease specialists - Discusses topics using modern insight, providing all necessary scientific information on each aspect - Includes scientific understanding and practical guidelines, which make it interesting for both research scientists and practitioners working with skin, soft tissue, bone, and joint infections
