Persisting Pandemics


Book Description

Persisting Pandemics explores the history of syphilis and AIDS to provide insights into the limits of biomedicine and our experience with epidemics today. Novel therapies developed for syphilis and AIDS became renowned in the medical field and the broader public sphere as exemplars of biomedical innovations. Public health campaigns based on these spectacular biomedical advances, however, have repeatedly fallen short of their goals to eliminate syphilis and AIDS in the population. The diseases epitomize the power of innovative biomedical therapies for the individual while unveiling limitations of scientific medicine in the domain of public health. The need for a public health approach to address mistrust in science, government indifference, and racial inequalities is relevant for strategies to eliminate COVID-19 today. Persisting Pandemics argues that campaigns to eliminate these diseases have not succeeded because they have not adequately addressed how diseases like AIDS, syphilis, and COVID spread unevenly in populations according to race, ethnicity, and geographic location. Despite the expectation of public health officials that medical advances would render epidemics obsolete, new diseases continue to emerge and spread regardless of efforts to eliminate them. Medical doctor and historian Powel H. Kazanjian concludes that narratives of syphilis, AIDS and COVID, unlike smallpox, do not contain a discrete ending—at least not within the timelines specified by their elimination campaigns. Instead they will be a continued part of our existence.




Persisting Pandemics


Book Description

Syphilis, AIDS, and COVID disprove any belief that scientific discoveries have ended the period of acute epidemic diseases that once defined 19th century life and replaced them with chronic cardiovascular diseases and cancers. Today, we cope with a greater array of epidemics than those who lived during the 19th century, even though we have the biomedical means to control them. Our cumulative experience with epidemic diseases, together with our attempts to eliminate them, remains a continued component of our existence.




The Threat of Pandemic Influenza


Book Description

Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.




Plague, Pestilence and Pandemic: Voices from History


Book Description

An eye-opening anthology from the bestselling editor of Histories of Nations, exploring how people around the globe have suffered and survived during plague and pandemic, from the ancient world to the present. Plague, pestilence, and pandemics have been a part of the human story from the beginning and have been reflected in art and writing at every turn. Humankind has always struggled with illness; and the experiences of different cities and countries have been compared and connected for thousands of years. Many great authors have published their eyewitness accounts and survivor stories of the great contagions of the past. When the great Muslim traveler Ibn Battuta visited Damascus in 1348 during the great plague, which went on to kill half of the population, he wrote about everything he saw. He reported, "God lightened their affliction; for the number of deaths in a single day at Damascus did not attain 2,000, while in Cairo it reached the figure of 24,000 a day." From the plagues of ancient Egypt recorded in Genesis to those like the Black Death that ravaged Europe in the Middle Ages, and from the Spanish flu of 1918 to the Covid-19 pandemic in our own century, this anthology contains fascinating accounts. Editor Peter Furtado places the human experience at the center of these stories, understanding that the way people have responded to disease crises over the centuries holds up a mirror to our own actions and experiences. Plague, Pestilence and Pandemic includes writing from around the world and highlights the shared emotional responses to pandemics: from rage, despair, dark humor, and heartbreak, to finally, hope that it may all be over. By connecting these moments in history, this book places our own reactions to the Covid-19 pandemic within the longer human story.




Persistent Viral Infections


Book Description

Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.




Plagued


Book Description

From the Black Death to Covid-19, pandemics have shaped and reshaped human society. Science and history can give us insight into two urgent questions: Why do they persist? And how can we survive them? Pandemics have been with us since Homo sapiens appeared on earth nearly 300,000 years ago. Forty percent of our genes are made of DNA from viruses. Yet we still remain vulnerable. Today, we are engulfed by a new pandemic: SARS-CoV-2 or the coronavirus that originated in China and, within four months, had spread to every country in the world. Thanks to advances in molecular biology and new tools with which to probe them, we are also in the midst of a golden age of understanding when it comes to our tiniest enemies. DNA technology is rewriting history, resolving disputes that have persisted for decades—and giving us crucial insights that may safeguard our future. Infectious Disease Specialist Dr. John Froude has worked on four continents over nearly 50 years, treating sufferers of plagues that arose over a century ago and never left us (like malaria and cholera) and battling new threats (like AIDS and Covid-19) as they emerge. In Plagued, he offers a gripping and timely account of the pandemics that have driven our evolution and shaped our history. Plagued tells the stories of yellow fever, smallpox, syphilis, the bubonic plague, influenza, typhus, cholera, malaria, tuberculosis, AIDS, and Covid-19. Blending science and narrative, Froude explores not only the unstoppable march of pestilence and its effects, but our intimate relationship with bacteria and viruses. He also explores the complex wonder that is human immunity, which itself is the consequence of an arms race between microbes and our animal ancestors that started 3.5 billion years ago. Along the way, we meet the dogged geniuses who have brought us back from the brink and see what it might take to do it again. Plagues arise without warning. But as we watch the current cataclysm unfold in real time, we have a unique opportunity to forge a path ahead that avoids both denial and panic. This timely book illustrates how lessons from the past, both distant and recent, may be the key to understanding why pandemics continue to plague us, and what can be done to stop them.




A Note on Long-Run Persistence of Public Health Outcomes in Pandemics


Book Description

Covid-19 is the single largest threat to global public health since the Spanish Influenza pandemic of 1918-20. Was the world better prepared in 2020 than it was in 1918? After a century of public health and basic science research, pandemic response and mortality outcomes should be better than in 1918-20. We ask whether historical mortality from pandemics has any predictive content for mortality in the ongoing Covid-19 pandemic. We find a strong persistence in public health performance in the early days of the Covid-19 pandemic. Places that performed poorly in terms of mortality in 1918 were more likely to have higher mortality today. This is true across countries and across a sample of US cities. Experience with SARS is associated with lower mortality today. Distrust of expert advice, lack of cooperation at many levels, over-confidence, and health care supply shortages have likely promoted higher mortality today as in the past.




Human Herpesviruses


Book Description

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.




Flu


Book Description

Veteran journalist Gina Kolata's Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It presents a fascinating look at true story of the world's deadliest disease. In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out. Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.




Epidemics and Society


Book Description

A wide-ranging study that illuminates the connection between epidemic diseases and societal change, from the Black Death to Ebola This sweeping exploration of the impact of epidemic diseases looks at how mass infectious outbreaks have shaped society, from the Black Death to today. In a clear and accessible style, Frank M. Snowden reveals the ways that diseases have not only influenced medical science and public health, but also transformed the arts, religion, intellectual history, and warfare. A multidisciplinary and comparative investigation of the medical and social history of the major epidemics, this volume touches on themes such as the evolution of medical therapy, plague literature, poverty, the environment, and mass hysteria. In addition to providing historical perspective on diseases such as smallpox, cholera, and tuberculosis, Snowden examines the fallout from recent epidemics such as HIV/AIDS, SARS, and Ebola and the question of the world’s preparedness for the next generation of diseases.