Personalized Management of Gastric Cancer


Book Description

This book offers essential information on basic and translational research in gastric cancer, while also illustrating potential opportunities for its application in clinical practice. Gastric cancer is the fourth-most-common cancer globally and the second-leading cause of cancer deaths. It is known to be a heterogeneous disease with varied responses to "one-size-fits-all" treatments. Expanding our knowledge of cancer cell genetics may help us to explore more effective treatments in gastric cancer. The research on molecular mechanisms and its clinical applications, both presented here, will help readers gain an in-depth understanding of gastric cancer and its effective treatment. The book's four sections cover personalized medicine, precise regional therapy, immunotherapy and nanomedicine in gastric cancer. Each part presents the state of art, recent advances and the authors' experiences. Moreover, several interesting cases are described to demonstrate how gastric cancer patients benefit from translational research. This informative and attractively presented book on precision treatment in gastric cancer, including experimental findings and clinical treatment options, offers a valuable resource for oncologists and graduate students working in the field of gastric cancer. Jia Wei, MD, PhD, is an associate professor at Nanjing University and the vice director of Clinical Cancer Institute of Nanjing University. She is now working as an oncologist in the Comprehensive Cancer Center, Affiliated Drum Tower Hospital to Medical School of Nanjing University. Baorui Liu, MD, PhD, is a professor at Nanjing University and director of the Clinical Cancer Institute of Nanjing University. He is also the director of the Comprehensive Cancer Center of Drum Tower Hospital.




Personalized Management of Gastric Cancer


Book Description

This book offers essential information on basic and translational research in gastric cancer, while also illustrating potential opportunities for its application in clinical practice. Gastric cancer is the fourth-most-common cancer globally and the second-leading cause of cancer deaths. It is known to be a heterogeneous disease with varied responses to “one-size-fits-all” treatments. Expanding our knowledge of cancer cell genetics may help us to explore more effective treatments in gastric cancer. The research on molecular mechanisms and its clinical applications, both presented here, will help readers gain an in-depth understanding of gastric cancer and its effective treatment. The book’s four sections cover personalized medicine, precise regional therapy, immunotherapy and nanomedicine in gastric cancer. Each part presents the state of art, recent advances and the authors’ experiences. Moreover, several interesting cases are described to demonstrate how gastric cancer patients benefit from translational research. This informative and attractively presented book on precision treatment in gastric cancer, including experimental findings and clinical treatment options, offers a valuable resource for oncologists and graduate students working in the field of gastric cancer.




Gastric Cancer


Book Description

Advances in Surgical Pathology: Gastric Cancer provides a concise, updated review of the pathological characteristics of gastric cancer, with an emphasis on exploring practical issues and recent developments. The book features current and emerging concepts in the field of gastric cancer, a disease whose management requires a multidisciplinary approach in which pathology plays a key role. Its six sections cover the essential histopathology of gastric cancer as well as related topics such as imaging evaluation, molecular diagnosis, and personalized treatment, among other areas of interest. Individual chapters written by international experts in the fields of pathology, gastrointestinal medical oncology, cancer epidemiology, and gastrointestinal radiology, address the fundamental issues surrounding gastric cancer, including its epidemiology, basic diagnostic features, differential diagnoses, pitfalls and complications, and treatments. Endoscopic evaluation and histology correlation are emphasized. The screening, clinical management, and treatment of gastric cancer are summarized in related book sections. Recent findings regarding the roles of immunohistochemistry and molecular testing in the diagnosis, prognosis, and personalized treatment of gastric cancer are also reviewed. The book also includes current knowledge regarding the molecular alteration of gastric cancer carcinogenesis and its impact on patient care.




Advances in Surgical Pathology: Gastric Cancer


Book Description

Advances in Surgical Pathology: Gastric Cancer provides a concise, updated review of the pathological characteristics of gastric cancer, with an emphasis on exploring practical issues and recent developments. The book features current and emerging concepts in the field of gastric cancer, a disease whose management requires a multidisciplinary approach in which pathology plays a key role. Its six sections cover the essential histopathology of gastric cancer as well as related topics such as imaging evaluation, molecular diagnosis, and personalized treatment, among other areas of interest. Individual chapters written by international experts in the fields of pathology, gastrointestinal medical oncology, cancer epidemiology, and gastrointestinal radiology, address the fundamental issues surrounding gastric cancer, including its epidemiology, basic diagnostic features, differential diagnoses, pitfalls and complications, and treatments. Endoscopic evaluation and histology correlation are emphasized. The screening, clinical management, and treatment of gastric cancer are summarized in related book sections. Recent findings regarding the roles of immunohistochemistry and molecular testing in the diagnosis, prognosis, and personalized treatment of gastric cancer are also reviewed. The book also includes current knowledge regarding the molecular alteration of gastric cancer carcinogenesis and its impact on patient care.




Gastrointestinal Cancers and Personalized Medicine


Book Description

Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50\% will develop recurrent disease despite aggressive treatments. A number of biomarkers currently guide treatment decisions for patients with gastrointestinal neoplasms. Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, furthering oncology along the path to "personalized cancer medicine". Future research efforts will focus on the identification of new biomarkers, moving existing biomarkers into earlier lines of therapy and evaluating new combinations of existing biomarkers and therapies. The aim of this Special Issue is to provide an overview of exciting new research in the area of gastrointestinal tumors that may establish innovative personalized management and precision medicine modalities for individualized care.




Management of Gastric Cancer


Book Description

Gastric cancer has been one of the great malignant scourges affecting man kind for as long as medical records have been kept. Until operative resection pioneered by Bilroth and others became available, no effective treatment was feasible and death from cancer was virtually inevitable. Even with resection by total gastrectomy, the chances of tumor eradication remained small. Over recent years, however, the situation has been changing. Some changes have resulted from better understanding of the disease, early detec tion, and better management techniques with applied clinical research, but the reasons for other changes are poorly understood. For example, the incidence of gastric cancer is decreasing, especially in westernized societies, where it has fallen from one of the most common cancers to no longer being in the top five causes of cancer death. Still it remains the number one killer of adult males in Japan and Korea. Whether the reduced incidence in western societies is a result of dietary changes or methods of food preservation, or some other reason, is as yet uncertain. Improvements in outcome have been reported from mass screening and early detection; more refined techniques of establishing early diagnosis, tumor type, and tumor extent; more radical surgical resection; and resection at earlier stages of disease.




Gastric Cardiac Cancer


Book Description

This book is designed to present readers with comprehensive, high-quality research results on almost all aspects of this carcinoma in clinical management, from correct determination of the esophagogastric junction, issues on cardiac mucosa, epidemiology, and natural history, to clinical, endoscopic, and histopathologic features and diagnostic pitfalls of this carcinoma at both early and advanced stages. Once diagnosed and correctly staged, clinical management of this carcinoma at the early stage is addressed primarily with endoscopic therapy employing the latest endoscopic technology such as endoscopic submucosal dissection, in which detailed technical topics of the endoscopic therapy are written by experts in the field with sections from pre-resection staging and patient preparation to post-resection complications and management. Subsequently, clinical management of gastric cardiac carcinoma at advanced stages is discussed at length with a personalized, multidiscipline approach with strategies from surgical resections with various methods, to pre-, peri- and post-resection chemoradiation therapies as well as the most advanced immunotherapy. A state-of-art approach with the results of meta-analyses and large-scale randomized double-blinded clinical trials are employed throughout these chapters. For patients at the terminal ill stage, the appropriate palliative care plan is presented by experienced clinicians armed with the latest clinical practice guidelines to better manage and help those patients in the last period of their lives.




Staging Laparoscopy


Book Description

Included here is a discussion of the pathophysiological aspects and risks of laparoscopic staging (such as trocar metastases) on the basis of international experience.




WHO Classification of Tumours of the Digestive System


Book Description

"The WHO Classification of Tumours of the Digestive System presented in this book reflects the views of a Working Group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, December 10-12, 2009"--P. [5].




Textbook of Personalized Medicine


Book Description

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.