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The Serotonin Receptors

Author : Bryan L. Roth

Publisher : Springer Science & Business Media

Page : 628 pages

File Size : 19,62 MB

Release : 2008-08-17

Category : Medical

ISBN : 1597450804

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Book Description

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.



Pharmacology of 5-HT6 receptors, Part I

Author :

Publisher : Academic Press

Page : 225 pages

File Size : 25,55 MB

Release : 2010-12-07

Category : Medical

ISBN : 0123849772

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Book Description

The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors. - Written by expert researchers - Covers all published literature to date in the field of 5-HT6 receptors





The Serotonin System

Author : Mark Tricklebank

Publisher : Academic Press

Page : 307 pages

File Size : 41,3 MB

Release : 2019-06-15

Category : Medical

ISBN : 0128133244

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Book Description

The Serotonin System: History, Neuropharmacology, and Pathology provides an up-to-date accounting on the physiology and pathophysiology of serotonin and the role it plays in behavioral functions. In addition, the book explores the potential roles of 5-HT1 in neurodevelopmental disorders and summarizes the history of the discovery and development of serotonergic drugs for the treatment of neuropsychiatric disorders. This concise, yet thorough, volume is the perfect introduction to this critical neurotransmitter. It is ideal for students and researchers new to the study of behavior, neuropsychiatry or neuropharmacology, but is also a great resource for established investigators who want a greater perspective on serotonin. - Examines the role of serotonin in physiological functions and neuropsychiatric disorders - Provides in-depth knowledge on all aspects of the serotonin system - Explores serotonergic receptors as targets for both current and new therapeutic compounds



Pharmacology of 5-HT6 Receptors

Author : Franco Borsini

Publisher : Academic Press

Page : 248 pages

File Size : 22,57 MB

Release : 2011

Category : Central nervous system

ISBN : 0123859026

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Book Description

Annotation The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized and they show a modulatory role in learning and memory processes and food intake.



The Role of 5-HT Systems on Memory and Dysfunctional Memory

Author : Alfredo Meneses

Publisher : Academic Press

Page : 95 pages

File Size : 43,31 MB

Release : 2014-03-11

Category : Science

ISBN : 0128010835

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Book Description

Drugs acting through 5-HT (5-hydroxytryptamine, or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson's disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory. - Examines and summarizes the recent advances in drugs that act through the 5-HT systems - Reviews findings in the context of brain disorders that involve memory deficits - Covers emergent targets for memory formation and memory alterations



Handbook of the Behavioral Neurobiology of Serotonin

Author : Christian Peter Müller

Publisher :

Page : 818 pages

File Size : 45,57 MB

Release : 2010

Category : Medical

ISBN : 9780123746344

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Book Description

Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitters, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood, and pathological alterations in the serotonergic system underlie behaviour and psychiatric conditions (among a host of very successful drugs targeting the serotoninergic system are Prozac and Zoloft). This is the first truly integrated handbook providing a broad overview over the many face



Receptor-Receptor Interactions

Author : Kjell Fuxe

Publisher : Springer Science & Business Media

Page : 577 pages

File Size : 13,61 MB

Release : 2013-03-13

Category : Computers

ISBN : 1468454153

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Book Description



Serotonin

Author : Fatima Shad Kaneez

Publisher : BoD – Books on Demand

Page : 318 pages

File Size : 30,74 MB

Release : 2017-07-26

Category : Medical

ISBN : 9535133616

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Book Description

Serotonin - A Chemical Messenger Between All Types of Living Cells is a very interesting book on the most ancient neurotransmitter, hormone and trophic factor serotonin or 5-hydroxytryptamine (5-HT). This unique chemical is present in all living cells including plants and animals. This book will take us through a serene journey of the evolutionary history of serotonin and its role from man to mollusk. There are many interesting chapters incorporated in this book, including novel approaches for detecting minor metabolites of serotonin in human plasma, production and function of serotonin in cardiac cells, immuno-thrombotic effects of serotonin in platelets to the identification and localization of serotonin in the nervous system and gonad of bivalve mollusks.



Frontiers in Pharmacology of Neurotransmitters

Author : Puneet Kumar

Publisher : Springer Nature

Page : 729 pages

File Size : 13,9 MB

Release : 2020-10-29

Category : Medical

ISBN : 9811535566

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Book Description

Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.