Pituitary Disorders throughout the Life Cycle


Book Description

The pituitary gland is often referred to as the master gland, coordinating hormonal signals from the hypothalamus and peripheral circulation to maintain homeostasis in the body. Patients with pituitary dysfunction are faced with challenges unique to each stage of their life cycle. For example, the goals of management for a hypopituitary adolescent transitioning to adulthood would be to optimize growth and sexual development. In early adulthood, approaches that optimize of fertility in men and women can be a priority, and the management approach will be very different from that of older adults requiring sex hormone replacement. This case-based guide will provide practical clinical guidance on approaches to the management of pituitary disorders organized by time of life, from childhood and fertile years through to older age. Sensibly divided into sections, various pituitary disorders and conditions are described and relevant treatment strategies are outlined. Sections included discussions of the unique considerations for the pituitary gland in childhood and adolescents, patients desiring fertility and pregnant patients, health optimization and non-tumoral diagnoses in adults, and management of disorders of the hypothalamic-pituitary axis in the elderly. Each chapter presents a clinical case vignette as an introduction to the concepts and a framework for the discussion of the diagnosis, management and unique consideration of each pituitary pathology. Practical and user-friendly, Pituitary Disorders throughout the Life Cycle is an excellent resource for practicing clinical endocrinologists (pediatric, transitional care, adult) and reproductive endocrinologists as well as specialty residents and trainees.




Pituitary Disorders


Book Description

Do you want to be up to date on the latest concepts of diagnosis and treatment of patients suffering from disorders of the pituitary gland? Are you looking for an expert guide to the best clinical management? If so, this is the book for you, providing a full analysis of pituitary disorder management from acromegaly to Addison's Disease; from Cushing's Disease to hypopituitarism; from hormone disorders to hormone replacement. Well-illustrated throughout, and with contributions from leading specialists in pituitary disease, inside you'll find comprehensive and expert coverage, including: Diagnosing pituitary disease Management options for each disorder Complications that can occur Psychological and psychosocial effects of pituitary disease What outcomes you and your patients can expect over the long term Current research and clinical trials related to pituitary disease Pituitary Disorders: Diagnosis and Management is the perfect clinical tool for physicians and health care providers from many related disciplines, and an essential companion for the best quality management of pituitary patients.




Gigantism and Acromegaly


Book Description

Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism




Pituitary Disorders of Childhood


Book Description

This unique book presents an up-to-date discussion of clinical disorders of the pituitary gland in children with specific emphasis on state-of-the-art diagnostic and treatment modalities, highlighting the newest scientific advances in genomics and molecular biology that clinician-scientists caring for children need to know. Chapters focus on the current knowledge base in genomics, pathophysiology, diagnosis, and medical and surgical management, organized into thematic sections. Part I discusses embryologic and genetic disorders, including genomics and congenital disorders of the pituitary. Part II presents acquired pituitary disorders, such as prolactinomas, Cushing's Disease, and both hormone secreting and non-secreting pituitary tumors. Subsequent sections cover posterior pituitary disorders, such as diabetes insipidus, functional hormone deficiencies of the hypothalamic-pituitary axis, including delayed puberty and pubertal disorders and growth hormone disorders, neuro-opthalmic disease, CNS radiation, childhood cancer treatment and traumatic brain injury. Authoritative and comprehensive, Pituitary Disorders of Childhood will serve as a precise guide for clinical endocrinologists and will guide future investigation into translational and clinical research on the pediatric pituitary.




Pituitary Disorders, An Issue of Endocrinology and Metabolism Clinics of North America


Book Description

This issue of Endocrinology and Metabolism Clinics, edited by Drs. Anat Ben-Shlomo and Maria Fleseriu, is devoted to Pituitary Disorders. Articles in this issue include: Pathogenesis of Pituitary Tumors; Prognostic Clinicopathological Classification of Pituitary Adenomas; Familial Isolated Pituitary Adenomas (FIPA) and Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene; Pitfalls of IGF1 and GH Assays; Acromegaly: Pharmacotherapy; Hypothalamo-pituitary-adrenal Axis Testing; Pharmacotherapy of Cushing Disease: New Targets; Prolactinomas; Non-functioning Pituitary Tumors; Cabergoline Use for Pituitary Tumors and Valvular Disorders; Aggressive Atypical Pituitary Tumors and Carcinoma; Outcomes of Endoscopic Transsphenoidal Pituitary Surgery; Efficacy and Complications of Pituitary Irradiation; Hypopituitarism: GH and ACTH Deficiency; Hypophysitis; Hypopituitarism After Traumatic Brain Injury; Quality of Life in Pituitary Diseases; Pituitary and Bone Disease; Pituitary Tumor Management in Pregnancy; and Pituitary Apoplexy.




Endoscopic Endonasal Transsphenoidal Surgery


Book Description

Currently, surgical management provides the definitive treatment of choice for most pituitary adenomas, craniopharyngiomas and meningiomas of the sellar region. The elegant minimally invasive transnasal endoscopic approach to the sella turcica and the anterior skull base has added a new dimension of versatility to pituitary surgery and can be adapted to many lesions in the region. In this multi-author book with numerous color illustrations the main aspects of the endonasal endoscopic approach to the skull base are presented, starting with a clear description of the endoscopic anatomy, the panoramic view afforded by the endoscope and the development of effective instruments and adjuncts. After the diagnostic studies, the strictly surgical features are considered in detail. The standard technique is described and particular aspects are treated, including the new extended approaches to the cavernous sinus, spheno-ethmoid planum and clival regions. The book stresses the importance of teamwork and has been produced by one of the pioneering groups in the field of endoscopic approaches to the pituitary. It is a useful guide primarily for neurosurgeons and sinonasal endoscopic surgeons but also for other specialists involved in the diagnosis and treatment of skull base lesions.




Diseases of the Pituitary


Book Description

Nineteen cutting-edge review articles by leading authorities provide a comprehensive overview of the normal function of the pituitary and of the diagnosis and treatment of pituitary disorders. Topics range from normal hypothalamic-pituitary interactions and the processes that disrupt them to new advances in pituitary imaging and appropriate surgical intervention in various pituitary disorders. Among the diseases discussed are congenital hypopituitarism, deficiency states, strategies for evaluating patients with hyperprolactinemia, Cushing's syndrome, acromegaly, and glycoprotein pituitary tumors.




Pituitary Disorders, An Issue of Endocrinology and Metabolism Clinics of North America


Book Description

This issue of Endocrinology and Metabolism Clinics will cover Pituitary Disorders. Curated by Dr. Niki Karavitaki, this issue will explore topics in the field that are relevant for practicing clinicians. This issue is one of four selected each year by the series Consulting Editor, Adriana G. Ioachimescu. The volume will include articles on: Epidemiology of pituitary disease, Advances in the imaging of pituitary tumours, WHO 2017 classification of pituitary tumours, Cancer immunotherapy and pituitary function, Advances in the medical treatment of Cushing’s disease, Nelson’s syndrome, Update on genetics of pituitary tumours, Dopamine agonists for pituitary tumours: benefits and risks, Acromegaly: Update on management and long-term morbidities, Endoscopic surgery for pituitary tumours, Aggressive pituitary adenomas and carcinomas, Diabetes insipidus: an update, Management of hypothalamic obesity, and Pituitary Centers of Excellence.




Growth Hormone Deficiency in Adults


Book Description

It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.




Pituitary Disorders, an Issue of Endocrinology and Metabolism Clinics of North America


Book Description

This issue of Endocrinology and Metabolism Clinics, edited by Drs. Anat Ben-Shlomo and Maria Fleseriu, is devoted to Pituitary Disorders. Articles in this issue include: Pathogenesis of Pituitary Tumors; Prognostic Clinicopathological Classification of Pituitary Adenomas; Familial Isolated Pituitary Adenomas (FIPA) and Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene; Pitfalls of IGF1 and GH Assays; Acromegaly: Pharmacotherapy; Hypothalamo-pituitary-adrenal Axis Testing; Pharmacotherapy of Cushing Disease: New Targets; Prolactinomas; Non-functioning Pituitary Tumors; Cabergoline Use for Pituitary Tumors and Valvular Disorders; Aggressive Atypical Pituitary Tumors and Carcinoma; Outcomes of Endoscopic Transsphenoidal Pituitary Surgery; Efficacy and Complications of Pituitary Irradiation; Hypopituitarism: GH and ACTH Deficiency; Hypophysitis; Hypopituitarism After Traumatic Brain Injury; Quality of Life in Pituitary Diseases; Pituitary and Bone Disease; Pituitary Tumor Management in Pregnancy; and Pituitary Apoplexy.