Pluripotency in Domestic Animal Cells
Author : Tiziana A. L. Brevini
Publisher :
Page : 56 pages
File Size : 22,54 MB
Release : 2013-12-31
Category :
ISBN : 9781489980540
Pluripotency in Domestic Animal Cells
Author : Tiziana A.L. Brevini
Publisher : Springer Science & Business Media
Page : 52 pages
File Size : 35,48 MB
Release : 2013-12-13
Category : Science
ISBN : 1489980539
Book Description
This addition to the Springer Brief in Stem Cells series focuses on aspects related to the specific mechanisms that ensure and control pluripotency and cell commitment in domestic animal species. This topic is generating rapidly-increasing interest due to the great potential for domestic animal species to be used as intermediate biomedical models, between the mouse and the human. The Brief addresses why we need large animal models for regenerative medicine. It also describes early embryo development with a careful and specific analysis of the regulatory mechanisms driving cleavage, polarization and genome activation in domestic species. How pluripotency is compartmentalized in domestic species as well as the different aspects that make the derivation of stem cells in domestic species very difficult are also addressed.
Transgenic Animals
Author : Louis-Marie Houdebine
Publisher : CRC Press
Page : 122 pages
File Size : 46,32 MB
Release : 2022-04-19
Category : Nature
ISBN : 1000448436
Book Description
During the past 20 years, transgenesis has become a popular technique and a crucial tool for molecular geneticists and biologists. Transgene expression is now better-controlled and even specifically inducible by exogenous factors. While these techniques have quite significantly transformed the experimental approaches taken by biologists, the applications are more limited than expected and concerns have arisen regarding biosafety as well as physiological, social, and philosophical issues. Transgenic Animals: Generation and Use contains articles on the techniques used to generate transgenic animals and a section on the preparation of vectors for the optimally controlled expression of transgenes. It also examines the use of transgenic animals in the study of gene function and human diseases, the preparation of recombinant proteins and organs for pharmaceutical and medical use, and the improvement of genetic characteristics of farm animals. Finally, it discusses more recent problems generated by transgenic animals including conservation of transgenic lines, specific database patenting, biosafety, and bioethics. Drawn from both academia and industry, the contributors to this monograph present in one concise volume all the relevant information on the different aspects of transgenesis. This book can be used as both a reference book and a textbook for specialized university courses and will be of interest to everyone involved in basic research in animal biology, molecular genetics, animal biotechnology, pharmaceutical science, and medicine.
Genomic, Proteomics, and Biotechnology
Author : RC Sobti
Publisher : CRC Press
Page : 420 pages
File Size : 25,44 MB
Release : 2022-12-29
Category : Medical
ISBN : 1000782565
Book Description
High-throughput molecular technologies ("omics") can help to decipher the contributions of different physiological systems and identify candidate molecules that are representative of different physiological pathways thereby allowing the discovery of biomarkers. Notably, the omics technologies along with and computational methods, bioprospecting, and artificial intelligence will continue to lead to better understanding of biological mechanisms that are responsible for physical attributes, or phenotypes. Research breakthroughs obtained through these technologies can be used to enhance productivity of food animals, meet the increasing demand for animal-sourced foods, enhance high-quality nutrient availability, ensure nutrient safety, mitigate the effects of climate variability, and result in new technologies that provide continued improvement in food security worldwide. Such breakthroughs are an urgent necessity because over the past 50 years, there has been an unprecedented increase in the world’s population, which will reach ten billion by the year 2050. Innovative and technological advancements that enhance all aspects of food production will arise from basic, fundamental research. Besides food, animal by-products have found many applications in the fields of pharmaceuticals, cosmetics, and household and industrial products. Hence, the need to ameliorate the productivity, reproductivity, growth performance, and disease resistance in animals has created a worldwide interest in gaining a deeper understanding of animal biology, biotechnology and genomics, and proteomics. The present volume thoroughly discusses the omics studies in domestic and non-domestic animals and their role in mitigation of various challenges ahead. The volume thus focuses on i. Omics (genomics, proteomics, transcriptomics, metabolonomics) technologies in identifying, characterizing biodiversity ii. Role of molecular techniques for improvement of domestic and non-domestic organisms iii. Animal and alternative model systems (using stem cells, tissue engineering, cell free systems, 3D platforms etc.) for studying life phenomena iv. Genetically modified organisms as factories for the products
The SAGE Encyclopedia of Stem Cell Research
Author : Eric E. Bouhassira
Publisher : SAGE Publications
Page : 1552 pages
File Size : 27,78 MB
Release : 2015-06-15
Category : Medical
ISBN : 150630124X
Book Description
The SAGE Encyclopedia of Stem Cell Research, Second Edition is filled with new procedures and exciting medical breakthroughs, including executive orders from the Obama administration reversing barriers to research imposed under the Bush administration, court rulings impacting NIH funding of research based on human embryonic stem cells, edicts by the Papacy and other religious leaders, and the first success in cloning human stem cells. Stem cell biology is clearly fueling excitement and potential in traditional areas of developmental biology and in the field of regenerative medicine, where they are believed to hold much promise in addressing any number of intractable medical conditions. This updated second edition encyclopedia will expand on information that was given in the first edition and present more than 270 new and updated articles that explore major topics in ways accessible to nonscientists, thus bringing readers up-to-date with where stem cell biology stands today, including new and evolving ethical, religious, legal, social, and political perspectives. This second edition reference work will serve as a universal resource for all public and academic libraries. It is an excellent foundation for anyone who is interested in the subject area of stem cell biology. Key Features: Reader’s Guide, Further Readings, Cross References, Chronology, Resource Guide, Index A Glossary will elucidate stem cell terminology for the nonscientist Statistics and selected reprints of major journal articles that pertain to milestones achieved in stem cell research Documents from Congressional Hearings on stem cells and cloning Reports to the President’s Council on Bioethics, and more
Rising Stars in Veterinary Regenerative Medicine: 2022
Author : Janina Burk
Publisher : Frontiers Media SA
Page : 168 pages
File Size : 16,18 MB
Release : 2023-12-18
Category : Medical
ISBN : 2832541240
Book Description
Veterinary patients, from companion to farm animals, play a key role in our society and economy as members of families which provide leisure or sustenance. Therefore, their health and welfare are of utmost importance and should be supported by all means available. The field of regenerative medicine offers new opportunities to understand and treat diseases, with a growing interest to benefit animals not only as models but also as patients. The rapid expansion of the veterinary regenerative medicine field demands for continuous innovation. A big share of the affiliated research is contributed by dedicated young researchers willing to advance the standard of animal care.
Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside
Author : Kuldip S. Sidhu
Publisher : Bentham Science Publishers
Page : 250 pages
File Size : 32,20 MB
Release : 2012
Category : Science
ISBN : 1608052893
Book Description
"Pluripotent stem cells have garnered tremendous interest in recent years, which is primarily driven by the hope of finding a cure for several debilitating human diseases. Cell transplantation (regeneratve medicine) offers considerable therapeutic potentia"
Textbook of Animal Biotechnology
Author : B Singh
Publisher : The Energy and Resources Institute (TERI)
Page : 715 pages
File Size : 21,94 MB
Release : 2005-01-01
Category : Science
ISBN : 817993327X
Book Description
Animal biotechnology is an integral component of agriculture. Supported with over 50 figures and more than 30 tables, this textbook is a must have for undergraduates and postgraduates of various agriculture and animal husbandry academia, teachers, professionals, and researchers in basic as well as applied animal sciences including biotechnology, nutrition, physiology and reproduction. The book covers various topics, including economically important livestock breeds, paradigm shifts in livestock production, biotechnology in animal nutrition and in livestock-assisted reproduction, and genomics and genetic engineering tools in livestock production and management.
Animal Models and Human Reproduction
Author : Heide Schatten
Publisher : John Wiley & Sons
Page : 757 pages
File Size : 31,11 MB
Release : 2017-01-13
Category : Science
ISBN : 1118881346
Book Description
Our knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Animal Models and Human Reproduction presents a comprehensive reference that reflects the latest scientific research being done in human reproductive biology utilizing domestic animal models. Chapters on canine, equine, cow, pig, frog, and mouse models of reproduction reflect frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, and inflammation. Chapters on non-human primate models also highlight recent advancements into such issues as human in vitro fertilization (IVF) and assisted reproductive technologies (ART). This book offers animal scientists, reproductive biology scientists, clinicians and practitioners, invaluable insights into a wide range of issues at the forefront of human reproductive health.
Pluripotent Stem Cells
Author : Deepa Bhartiya
Publisher : BoD – Books on Demand
Page : 642 pages
File Size : 18,76 MB
Release : 2013-08-28
Category : Science
ISBN : 9535111922
Book Description
Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.
