Author : Teresa Kowalska
Publisher : CRC Press
Page : 441 pages
File Size : 34,75 MB
Release : 2006-02-03
Category : Medical
ISBN : 1420005820
Preparative Layer Chromatography explains how this method is used for separating large quantities of mixtures containing a wide variety of important compounds. It offers a broad review of preparative layer chromatography (PLC) applications and adaptable working procedures for microseparations involving organic, inorganic, and organometallic compoun
Author : H. Schmidt-Traub
Publisher : John Wiley & Sons
Page : 545 pages
File Size : 37,95 MB
Release : 2012-09-27
Category : Science
ISBN : 3527649301
Completely revised and substantially extended to reflect the developments in this fast-changing field. It retains the interdisciplinary approach that elegantly combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes. It also covers recent advances in preparative chromatographic processes for the separation of "smaller" molecules using standard laboratory equipment as well as the detailed conception of industrial chemical plants. The increase in biopharmaceutical substances is reflected by new and revised chapters on different modifications of continuous chromatography as well as ion-exchange chromatography and other separation principles widely used in biochromatography. Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on stationary phases, selection of chromatographic systems and process concepts. A completely new chapter deals with engineering and operation of chromatographic equipment. Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes. Essential for chemists and chemical engineers in the chemical, pharmaceutical, and food industries.
Author : Colin Poole
Publisher : Elsevier
Page : 692 pages
File Size : 46,45 MB
Release : 2023-01-14
Category : Science
ISBN : 0323983014
Instrumental Thin-Layer Chromatography, Second Edition offers a comprehensive source of authoritative information on all aspects of instrumental thin-layer chromatography. The use of short, topic-focused chapters facilitates identifying information of immediate interest for familiar or emerging uses of thin-layer chromatography. The book gives those working in both academia and industry the opportunity to learn, refresh, or deepen their understanding of fundamental and instrumental aspects of thin-layer chromatography, as well as the tools to interpret and manage chromatographic data. The book serves as a practical consolidated guide to the selection of separation conditions and the use of auxiliary techniques. This fully updated new edition restores the contemporary character of the book for those involved in advancing the technology, analyzing data produced, or applying the technique to new application areas. Some chapters have been consolidated to make room for topics not covered in the first edition, reflecting general changes in the field of thin-layer chromatography, especially in effects-directed detection, convenient interfaces for advanced spectroscopic detection, and greater automation possibilities. This book is a valuable reference for anyone who needs to acquire fundamental and practical information to facilitate progress in research and management functions utilizing information acquired by thin-layer chromatography. - Features individual chapters written by recognized authoritative and visionary experts in the field - Provides an overview and focused treatment of a single topic - Provides tables and diagrams with commonly used data to facilitate practical work, comparison of results, and decision-making - Places modern developments in the research literature into a general context not always apparent to inexperienced users of the technique - Offers comprehensive updates to all chapters - Includes new chapters on instrument platforms, effects-directed detection, data analysis tools, small-scale and microfluidic planar separation systems, and applications to the separation of amino acids and peptides, the analysis of saccharides and lipids, and forensic analysis
Author : Joseph C. Touchstone
Publisher :
Page : 430 pages
File Size : 19,48 MB
Release : 1983-03
Category : Science
ISBN :
A practical how-to guide to all the basic techniques needed to practice thin layer chromatography in biochemical/pharmaceutical research and quality control. This updated edition presents the most current techniques as well as the hows and whys of TLC. Provides step-by-step methods for performing the separations as well as doing related tasks, such as applying the sample, selecting the mobile phase, and quantitation. Includes a special chapter on how to select solvents for the development of a chromatogram to separate specific individual components of a mixture.
Author : B.A. Bidlingmeyer
Publisher : Elsevier
Page : 357 pages
File Size : 12,50 MB
Release : 1987-07-01
Category : Science
ISBN : 0080858414
This volume provides a straightforward approach to isolation and purification problems with a thorough presentation of preparative LC strategy including the interrelationship between the input and output of the instrumentation, while keeping to an application focus.The book stresses the practical aspects of preparative scale separations from TLC isolations through various laboratory scale column separations to very large scale production. It also gives a thorough description of the performance parameters (e.g. throughput, separation quality, etc.) as a function of operational parameters (e.g. particle size, column size, solvent usage, etc.). Experts in the field have contributed a well balanced presentation of separation development strategies from preparative TLC to commercial preparative process with practical examples in a wide variety of application areas such as drugs, proteins, nucleotides, industrial extracts, organic chemicals, enantiomers, polymers, etc.
Author : Satinder Ahuja
Publisher : Academic Press
Page : 604 pages
File Size : 34,11 MB
Release : 2010-11-11
Category : Medical
ISBN : 0123759811
Handbook of Modern Pharmaceutical Analysis, Second Edition, synthesizes the complex research and recent changes in the field, while covering the techniques and technology required for today's laboratories. The work integrates strategy, case studies, methodologies, and implications of new regulatory structures, providing complete coverage of quality assurance from the point of discovery to the point of use. - Treats pharmaceutical analysis (PA) as an integral partner to the drug development process rather than as a service to it - Covers method development, validation, selection, testing, modeling, and simulation studies combined with advanced exploration of assays, impurity testing, biomolecules, and chiral separations - Features detailed coverage of QA, ethics, and regulatory guidance (quality by design, good manufacturing practice), as well as high-tech methodologies and technologies from "lab-on-a-chip" to LC-MS, LC-NMR, and LC-NMR-MS
Author : Ivor Smith
Publisher : Elsevier
Page : 476 pages
File Size : 14,5 MB
Release : 2013-10-22
Category : Science
ISBN : 1483279928
Chromatographic & Electrophoretic Techniques, Fourth Edition, Volume I: Paper and Thin Layer Chromatography presents the methods of paper and thin layer chromatography. This book discusses the practical approach in the application of paper and thin layer chromatography techniques in the biological sciences. Organized into 18 chapters, this edition begins with an overview of the clinical aspects related to the detection of those metabolic diseases that can result in serious illness presenting in infancy and early childhood. This text then discusses the three major types of screening for inherited metabolic disorders in which paper or thin-layer chromatography are being used, including screening the healthy newborn population, screening the sick hospitalized child, and screening mentally retarded patients. Other chapters consider the procedures for thin layer chromatography. This book discusses as well the complexity of amino acid mixtures present in natural products. The final chapter deals with the detection of synthetic basic drugs. This book is a valuable resource for chemists and toxicologists.
Author : Anurag Rathore
Publisher : CRC Press
Page : 418 pages
File Size : 33,91 MB
Release : 2002-09-26
Category : Medical
ISBN : 1135564140
Presenting guidelines to predict and improve separation system performance, this book contains numerous case studies illustrating the practice of scale-up principles in process development. It offers solutions to limitations that occur in real-world purification schemes; methods to model, optimize, and characterize nonlinear separation processes; d
Author : Dr. Inamuddin
Publisher : Springer Science & Business Media
Page : 220 pages
File Size : 35,51 MB
Release : 2013-11-12
Category : Science
ISBN : 9400777353
This book presents a unified outlook on counter-current, ion size exclusion, supercritical fluids, high-performance thin layers, and gas and size exclusion chromatographic techniques used for the separation and purification of organic and inorganic analytes. It also describes a number of green techniques, green sample preparation methods and optimization of solvent consumption in the chromatographic analysis of organic and inorganic analytes. This book offers a valuable resource not only for learners, but also for more experienced chromatographers, conveying a deeper understanding of green chromatographic techniques, green solvents and preparation methods.
Author : Monika Waksmundzka-Hajnos
Publisher : CRC Press
Page : 898 pages
File Size : 42,89 MB
Release : 2008-03-04
Category : Science
ISBN : 1420046780
Thin layer chromatography (TLC) is increasingly used in the fields of plant chemistry, biochemistry, and molecular biology. Advantages such as speed, versatility, and low cost make it one of the leading techniques used for locating and analyzing bioactive components in plants. Thin Layer Chromatography in Phytochemistry is the first sourc
