Adrenal Imaging


Book Description

Imaging of the adrenal gland has made tremendous progress in the last decade as new technologies continue to evolve. Adrenal Imaging highlights the pertinent clinical and pathological information that underpins the accurate interpretation and use of adrenal imaging. Written by a prestigious group of international contributors, individual chapters in Adrenal Imaging serve as a relevant and up-to-date reference of adrenal imaging findings, algorithms and techniques in CT, MR nuclear medicine, intervention and trauma. Summary sections at the end of each chapter illuminate key teaching points to enhance retention.




Genetics in Endocrinology


Book Description

An extensive body of evidence highlights the crucial importance of endocrine genetics. Examples range from human growth disorders and obesity to cancers of the prostate and breast. A pivotal part of the Modern Endocrinology Series, this book presents major biological studies underlining the significance of data obtained from knock-out mice, as well as from transgenic animals. Gene therapy and laboratory evaluation and screening of genetic endocrine diseases are covered, as are many of the classical endocrine diseases.




Primary Aldosteronism


Book Description

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene – KCNJ5 – in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.




Adrenal Disorders


Book Description

In Adrenal Disorders, a panel of distinguished physicians and researchers select the most relevant new findings and integrate them into the existing body of clinical knowledge on adrenal pathologies. The book includes important reviews of disturbances in cortisol homeostasis, and new concepts regarding adrenal tumors and hereditary adrenal diseases. Also discussed are mineralocorticoids and the syndromes of mineralocortoid excess and aldosterone synthase deficiency. Authoritative and insightful, Adrenal Disorders provides physicians and scientists with a comprehensive, state-of-the-art practical guide to the devastating diseases of the adrenals that are so often difficult to diagnose and treat.







Endocrine Hypertension


Book Description

Several genetic, biochemical and radiologic discoveries have impacted the management of endocrine hypertension, while surgical procedures have revolutionized treatment of patients with endocrine hypertension. This text contains the proceedings of a 2001 workshop on the topic.




Diagnosis and Management of Endocrine Disorders in Interventional Radiology


Book Description

This book provides a comprehensive guide for selective venous sampling procedures and the role of interventional radiologists in the care and treatment of patients with endocrine disorders. Disorders of the endocrine system involve an imbalance in the natural homeostasis of the hormones produced by the glands in the body. There are a variety of endocrine conditions that are characterized by either hormonal hyposecretion or hypersecretion. Percutaneous selective venous sampling is the gold standard diagnostic tool for the medical and surgical management of patients with a variety of such disorders. Selective venous sampling is a minimally invasive interventional procedure that interventional radiologists perform to localize sites of abnormal hormone secretion. Computed tomography and magnetic resonance imaging are the most used diagnostic imaging modalities in patients with the suspected endocrine disorder; however, their specificity is not optimal, and identifying a culprit gland is difficult based on imaging findings alone. Therefore, the ultimate decision for management depends on the outcome of selective venous sampling. As these various venous samplings are increasingly performed worldwide, the collaboration between interventional radiology, endocrinology, surgical endocrinology, surgical oncology, neurosurgery, and gynecology teams is essential. With limited literature on the topic, this volume fills the gap with in-depth coverage of selective venous sampling alongside the pathophysiology, epidemiology, clinical diagnosis, as well as medical, surgical, and interventional management of endocrine disorders. The book is divided into five parts: Clinical, Laboratory, and Radiological Diagnosis of Endocrine Disorders; Selective Venous Sampling in Interventional Radiology; Medical Treatment of Endocrine Disorders; Surgical Treatment of Endocrine Disorders; Interventional Treatment of Endocrine Disorders. Throughout these parts, endocrine disorders that require venous sampling are covered in depth: primary aldosteronism, primary hyperparathyroidism, Cushing’s disease, hormone-secreting pancreatic adenomas, and androgen-secreting ovarian tumors. There is additionally an emerging role for interventional management in thyroid gland disorders, which is covered here. This is an ideal guide for interventional radiologists caring for patients with endocrine disorders, as well as endocrinologists, endocrine surgeons, surgical oncologists, otolaryngologists, neurosurgeons, gynecologists, and nephrologists.




Aldosterone-Mineralocorticoid Receptor


Book Description

This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.




Endocrine Hypertension


Book Description

The prevalence of hypertension is almost three times as high as that of diabetes mellitus type 2, with both conditions being major risk factors for stroke, ischemic heart disease, cardiac arrhythmias, and heart failure. The exact prevalence of hypertension related to hormonal derangements (endocrine hypertension) is not known but estimated to affect less than 15% of hypertensive patients. Recent scientific discoveries have increased the understanding of the pathophysiologic mechanisms of hypertension. In Endocrine Hypertension, a renowned panel of experts provides a comprehensive, state-of-the-art overview of this disorder, discussing when to assign an endocrine cause in one of many conditions that may present with hypertension. The first part of Endocrine Hypertension is dedicated to adrenal causes. The second part of the volume concerns potential nonadrenal causes of hypertension, such as growth hormone excess or deficiency, primary hyperparathyroidism, vitamin D deficiency, testosterone deficiency, insulin resistance, obesity-associated hypertension, and the role of central mineralocorticoid receptors and cardiovascular disease. An important contribution to the literature, Endocrine Hypertension is an indispensable reference not only for endocrinologists, diabetologists, and adrenal investigators, but also for translational scientists and clinicians from cardiology, internal medicine, pediatrics, family medicine, geriatrics, urology, and reproductive medicine / gynecology.




Practical Clinical Endocrinology


Book Description

This practical book aims to cover the whole scope of clinical endocrinology, including both common and selected rare but important diseases, with an emphasis on practical clinical management. A number of different questions and problems in clinical routine are discussed in this book in an unconventional format. Each topic begins with the presentation of a typical clinical case, and then the topic is approached in a question and answer format linked to the clinical case presented, highlighting the most important questions in diagnosis, differential diagnosis and therapy. Numerous figures and tables are included to help understanding. The book is chiefly intended for doctors in training (preparing for boarding exam in endocrinology or internal medicine), but also for established clinicians who want to broaden or refresh their skills. University students of medicine can also find this book interesting.