Problem Solving through Precision Oncology


Book Description

Winner of the BMA Oncology Book of the Year Award. This practical learning and reference handbook provides an overview of the latest progress in the developing field of precision oncology, plus a ground breaking collection of case studies ("Problems") showing precision oncology in practice. The book includes a clear, readable summary of developments, alongside real-life case studies, providing a valuable update for all involved in the oncology community. The editors lead research and clinical teams at four UK centres of excellence in the field.




Problem Solving in Acute Oncology


Book Description

Created in partnership with the Association of Cancer Physicians (ACP) Structured problem solving approach illustrated through 38 case studies Suitable for acute oncology teams including in the community, and trainees Provides a template for acute service development and emergency treatment The development and delivery of acute oncology services have undoubtedly improved the care of cancer patients, the management of acute complications of cancer and its treatment, and our approaches to diagnosing patients who present with cancer and no obvious primary site. There remains a need to ensure that practitioners are kept fully informed and up-to-date about the appropriate clinical care to be provided in the setting of acute oncology, and to continue a dialogue on the best way to deliver acute oncology services within limited resources. Since the first edition of Problem Solving in Acute Oncology was published there has been continued development and expansion of services. The importance of the involvement of primary care in delivering acute oncology nationally has been increasingly recognized, leading to the development of ever stronger links between the two. Closer working with acute medicine physicians has also improved the care of acute oncology patients; work is ongoing to encourage closer collaboration between acute oncology services and clinical haematology. This updated text is particularly helpful and timely. It will serve as a valuable resource for those who continue to develop excellent acute oncology services, as well as provide a source of training and an update for clinicians working in this challenging clinical area. This book proposes a template that can be used by any professional involved in the planning and delivery of acute oncology care around the world. The book is formally supported by the Association of Cancer Physicians (ACP). This highly patient-centred, readable text will be of value to clinicians, healthcare strategic and operations managers, and doctors in training, in their daily work.




Problem Solving in Cancer Immunotherapy


Book Description

· a multidisciplinary review including the latest developments in cancer immunotherapy from over 70 experts and leaders · hands-on, practical guide to immunotherapy for hospital and community teams, GPs and allied care professionals, including 23 case studies · a valuable learning tool for doctors, nurses, graduate medical trainees, care managers and anyone involved in cancer care produced in partnership with the Association of Cancer Physicians (ACP) Editors and authors have drawn on their expertise and growing experience of immunotherapy to produce this practical guide to cancer immunotherapy. It provides a compendium of best practice, including 23 case studies to act as models for professionals making decisions, either for individual patients or as the basis for using immunotherapy across an organisation, planning area, region or country. As well as introducing key concepts, expert practitioners provide a guide to future treatments using novel technologies, discuss key problems and suggest solutions, and consider the costs of immunotherapy treatments. This guide is designed as a handbook for practising clinicians and professionals. It is also an excellent training tool that will help new teams and clinical staff to align thinking, develop procedures, and adopt best practice.




Problem Solving in Patient-Centred and Integrated Cancer Care


Book Description

Winner of the BMA Oncology Book of the Year Award. The authors provide a compendium of best practice, including 25 case studies to act as models for professionals to make decisions, either for individual patients or as the basis for policy across an organisation, planning area, region or country. This guide is designed as a handbook for practising clinicians and professionals. It is also an excellent training tool, which will help new teams and clinical staff to align thinking, develop procedures, and adopt best practice.




Problem Solving in Cancer and Fertility


Book Description

The treatment of cancer in young women and men is increasingly turning from focusing purely on survival to a recognition of the long-term effects of treatment on subsequent quality of life. In this regard, fertility is a very high priority for patients. This is the first book to explain the latest techniques in fertility preservation. Chapters cover fertility preservation in both women and men, management of cancer in pregnancy, egg donation and surrogacy, hormone replacement options, counselling and ethical issues. A multidisciplinary team of over 60 specialists were involved in this work, with contributions from leading obstetricians, medical oncologists, gynaecological oncologists, urologists and fertility specialists. The book is formally supported by the Association of Cancer Physicians (ACP). This highly patient-centred, readable text will be of value to a wide range of clinicians and physicians, and doctors in training, in their daily work.




Precision Medicine and Artificial Intelligence


Book Description

Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. - Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions - Provides background, milestone and examples of precision medicine - Outlines the paradigm shift towards precision medicine driven by value-based systems - Discusses future applications of precision medicine research using AI - Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine




End of Life Choices for Cancer Patients


Book Description

Legal change on the provision of assisted dying by healthcare professionals has occurred in a substantial number of jurisdictions. This work brings together contributions on end of life choices from experienced professionals from oncology disciplines, palliative care, law, nursing and professions allied to medicine. The goals are: • To better inform cancer care professionals and the wider community about developments in choices in end of life care for cancer patients internationally. • To better answer questions from patients and respond to their requests, including questions about and requests for assisted dying in countries where it is legal. • To have a balanced and well-informed dialogue about choices available to patients, without developing a formal policy position on change in law. • To provide a basis of information for future educational activities.




'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine


Book Description

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.




Genomic and Precision Medicine


Book Description

Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. - Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers - Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice - Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice - Covers case studies that highlight the practical use of genomics in the management of patients




Precision Oncology and Cancer Biomarkers


Book Description

This open access book reflects on matters of social and ethical concern raised in the daily practices of those working in and around precision oncology. Each chapter addresses the experiences, concerns and issues at stake for people who work in settings where precision oncology is practiced, enacted, imagined or discussed. It subsequently discusses and analyses bioethical dilemmas, scientific challenges and economic trade-offs, the need for new policies, further technological innovation, social work, as well as phenomenological research. This volume takes a broad actor-centred perspective as, whenever cancer is present, the range of actors with issues at stake appears almost unlimited. This perspective and approach opens up the possibility for further in-depth and diverse questions, posed by the actors themselves, such as: How are cancer researchers navigating biological uncertainties? How do clinicians and policy-makers address ethical dilemmas around prioritisation of care? What are the patients’ experiences with, and hopes for, precision oncology? How do policy-makers and entrepreneurs envisage precision oncology? These questions are of great interest to a broad audience, including cancer researchers, oncologists, policy-makers, medical ethicists and philosophers, social scientists, patients and health economists.