Phytochemistry of Medicinal Plants


Book Description

Phytochemicals from medicinal plants are receiving ever greater attention in the scientific literature, in medicine, and in the world economy in general. For example, the global value of plant-derived pharmaceuticals will reach $500 billion in the year 2000 in the OECD countries. In the developing countries, over-the-counter remedies and "ethical phytomedicines," which are standardized toxicologically and clinically defined crude drugs, are seen as a promising low cost alternatives in primary health care. The field also has benefited greatly in recent years from the interaction of the study of traditional ethnobotanical knowledge and the application of modem phytochemical analysis and biological activity studies to medicinal plants. The papers on this topic assembled in the present volume were presented at the annual meeting of the Phytochemical Society of North America, held in Mexico City, August 15-19, 1994. This meeting location was chosen at the time of entry of Mexico into the North American Free Trade Agreement as another way to celebrate the closer ties between Mexico, the United States, and Canada. The meeting site was the historic Calinda Geneve Hotel in Mexico City, a most appropriate site to host a group of phytochemists, since it was the address of Russel Marker. Marker lived at the hotel, and his famous papers on steroidal saponins from Dioscorea composita, which launched the birth control pill, bear the address of the hotel.




Modern Phytochemical Methods


Book Description

This volume contains reviews which are based on a symposium, given th at the 30 meeting of The Phytochemical Society of North America, held at Laval University in Quebec City, Canada on August 11-15, 1990. During the past two decades, there have been major new developments in methods which can be applied toward the isolation, separation and structure determination of complex natural products. Therefore, the topic of this symposium, "Modem Phytochemical Methods", is a very timely one. The organizers of the symposium recognized that it would not be possible to cover in detail all new advances in phytochemical methodology. It was therefore decided to emphasize general reviews on recent developments of major separation techniques such as high performance liquid chromatography as well as supercritical fluid chromato graphy. In addition, advances in commonly used structure determination methods, mainly NMR and MS, are reviewed. Other topics include methodo logies of micro-sampling for isolation and analysis of trichome constituents as well as recent breakthroughs on biosynthetic studies of monoterpenes using "enriched" basal cells of trichomes. The volume concludes with a review of quantitative structure-activity relationship (QSAR) studies of biologically active natural products. In Chapter I, K. Hostettmann and his colleagues give a general review of recent developments in the separation of natural products with major emphasis on preparative separations of biologically active plant constituents. The authors present a comparison of droplet countercurrent chromatography (OCCC) with the highly rapid and more versatile centrifugal partition chromatography (CPC).




Phytochemical Signals and Plant-Microbe Interactions


Book Description

Proceedings of a joint Meeting of the Phytochemical Society of North America and the Phytochemical Society of Europe held in Noordwijkerhout, The Netherlands, April 20-23, 1997




Secondary Metabolism in Model Systems


Book Description

The chapters presented in Secondary Metabolism in Model Systems are a microcosm of what the recent completion, or near completion, of various genome projects are enabling biochemists to understand not only about control and regulation of secondary metabolism, and how various pathways relate to each other, but also about its relation to primary metabolism. A major paradigm shift is occurring in the way researchers need to view "secondary" metabolism in the future.It is also clear that model systems, such as the ones discussed in the symposium, are providing new information and insight almost faster than researchers can process it! The volumes in this series contain articles on developing topics of interest to scientists, students and individuals interested in recent developments in the biochemistry, chemistry and molecular biology of plants. - An excellent series volume covering the advances in understanding of gene functions, a high profile area of research due to recent genome projects - This book provides essential information on new model systems available to biochemists - The chapters in this volume are based on the papers presented in the symposium entitled "Secondary Metabolism in Model Systems"




Phytochemical Diversity and Redundancy in Ecological Interactions


Book Description

Diversity within and among living organisms is both a biological impera tive and a biological conundrum. Phenotypic and genotypic diversity is the critical currency ofecological interactions and the evolution of life. Thus, it is not unexpected to find vast phytochemical diversity among plants. However, among the most compelling questions which arise among those interested in ecological phytochemistry is the extent, nature, and reasons for the diversity of chemieals in plants. The idea that natural products (secondary metabolites) are accidents of metabolism and have no biological function is an old one which has resurfaced recently under a new term "redundancy. " Redundancy in the broader sense can be viewed as duplication of effort. The co-occurrence of several classes of phytochemieals in a given plant may be redundancy. Is there unnecessary duplication of chemical defense systems and ifso, why? What selective forces have produced this result? On the other hand, why does the same compound often have multiple functions? At a symposium of the Phytochemical Society of North America held in August 1995, in Sault Ste. Marie, Ontario, Canada, the topic "Phytochernical Redundancy in Ecological Interactions" was discussed. The chapters in this volume are based on that symposium. They both stimulate thought and provide some working hypotheses for future research. It is being increasingly recognized that functional diversity and multiplicity of function of natural products is the norm rather than the exception.




Regulation of Phytochemicals by Molecular Techniques


Book Description

The papers assembled in this volume were originally presented at the joint meeting of the Phytochemical Society of North America and the Mid-Atlantic Plant Molecular Biology Society, in August 2000. The symposium from which these chapters were prepared was entitled "Regulation of Phytochemicals by Molecular Techniques" and was organised by James Saunders and Ben Matthews. This joint meeting was timely because of recent landmark advances in molecular biology and genomics as well as the renewed interest in phytochemistry as a rich source of nutraceuticals, drugs, and alternatives to synthetic agriculture pesticides. Progress in genome sequencing in plants such as Arabidopsis and rice has been remarkable, as have expressed sequence tag (EST) projects in other plants, including maize and soybean. Recently, private and public sector participants of the Human Genome Project announced that a rough draft of the human genome has been constructed. These advances directly influence phytochemical investigations by providing both insight and tools for exploring and manipulating genomes. The chapters cover a wide range of applications from molecular biology to phytochemistry, and from basic studies on promoters and gene expression to pathway regulation and engineering with transformed plants. A number of noteworthy aspects emerge from this volume: applications of molecular biology to phytochemical practical problems are succeeding; newly emerging molecular tools promise to open new doors to discovery; and remarkable progress has already occurred in phytochemical pathway engineering.




Phytochemical Potential of Tropical Plants


Book Description

Throughout the tropics, vast areas of rainforest and other biologically diverse lands are being cleared for agricultural or related uses. Rainforests, the most dramatic example of tropical habitat destrucLion, are estimated to be disappearing at the rate of up to 20.4 million hectares per year world-wide (based on FAO estimates; see World Resources 1990-1991, Oxford University Press) more than 2% of the total area covered by tropical rainforests per year. Destruction of these complex habitats results in the irreversible loss of both plant and animal diversity, and dramatically illustraLes the need to investigate these threatened species for potentially useful constituents-especially the identification and characterization of novel biologically-active phytochemicals with pharmacologiical and/or pesticidal properties. This volume is based on papers presented by invited speakers at an international symposium entitled "Phytochemical POlential of Tropical Plants: held in conjunction with the second joint meeting of the Phytochemical nd Societies of Europe and North America, as well as the 32 annual meeting of the latter society. The meeting was held at the Deauville Hotel, Miami Beach, Florida, USA from August 8-12,1992. One hundred and twenty-five participants from more than 20 countries attended this meeting.




Phytochemicals in Human Health Protection, Nutrition, and Plant Defense


Book Description

Proceedings of the 38th Annual Meeting at the Phytochemical Society of North America on Phytochemicals in Human Health Protection, Nutrition and Plant Defense, held July 26-31, 1998 in Pullman, WA, USA




Functionality of Food Phytochemicals


Book Description

Phytochemists are aware that their focus of interest is receiving attention from a wider segment of society and from a greater diversity of disciplines within the scientific community than ever before. Nonetheless, they were bemused to learn three years ago that "until recently scientists didn't even know phytochemi cals existed" (Newsweek, April 24, 1994). Changing public perception of the positive contributions of phytochemicals to human well-being has foundations in scientific advances. With popular reports emphasizing the important implica tions of phytochemicals in the daily lives of people, there is a pressing need for those working in this area to explain their diverse scientific activities to the public. Chemicals from plant foods are linked through epidemiological and ex perimental studies with reduced incidence of chronic degenerative diseases. Phytomedicines, standardized according to particular constituents, are making increasing contributions to health care. Naturally occurring constituents of plants are recognized as fundamental to the appeal, quality, and marketability of food products. In light of such developments, perceptions by phytochemists of their own discipline and its applications are expanding. Until recently, food phyto chemistry largely implied food toxicants. Food plants were familiar, but seldom the source of novel economically important compounds. Increasingly sophisti cated methods of analysis, however, have opened new opportunities for under standing the nature and functions offood constituents, and for manipulating them to improve the quality, acceptability, and value of food products.




Integrative Plant Biochemistry


Book Description

The publication of this volume marks the 40th anniversary of the Recent Advances in Phytochemistry series which has essentially documented a history of the origins of Phytochemistry. The 45th annual meeting of the Phytochemical Society of North America (PSNA) was held July 13-August 3, 2005 in La Jolla, California, USA. The meeting was hosted by the Salk Institute for Biological Studies. The theme of the meeting was – Integrative Plant Biochemistry as we Approach 2010. The focus was "to celebrate the past accomplishments of the PSNA and its focus, the growing importance of phytochemistry and plant biochemistry to the public, and to set a course for the future, by linking the past with the present and attracting a wider breath of scientists and disciplines to the society." Integrative Plant Biochemistry summarizes a number of important methodological approaches and innovative techniques that were discussed at the meeting: - Biosynthesis and Regulation of Signaling Molecules - Conservation and Divergence in Enzyme Function - Translational Opportunities in Plant Biochemistry - Temporal and Spatial Regulation of Metabolism - Lipids, Fatty Acids and Related Molecules - Metabolic Networks Each chapter in this volume concludes with a short summary and addresses the expected future directions of the work. The series marks the transition and progression of the dramatic integration of classical phytochemistry into molecular plant biology. - Explores the growing importance of phytochemistry and biochemistry - Discusses important methodological approaches and innovative techniques - Representation from a unique interdisciplinary forum of scientists at the 45th Annual meeting of the Phytochemical Society of North America