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Progress in the Chemistry of Organic Natural Products 105

Author : A. Douglas Kinghorn

Publisher : Springer

Page : 221 pages

File Size : 31,40 MB

Release : 2017-02-13

Category : Science

ISBN : 331949712X

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Book Description

The first contribution reviews the occurrence of xanthine alkaloids in the plant kingdom and the elucidation of the caffeine biosynthesis pathway, providing details of the N-methyltransferases, belonging to the motif B' methyltransferase family which catalyze three steps in the four step pathway leading from xanthosine to caffeine. The second contribution in this book provides a background on the molecule and related compounds and update knowledge on the most recent advances in Iboga alkaloids. The third contribution presents a comprehensive analysis of frequently occurring errors with respect to 13C NMR spectroscopic data and proposes a straightforward protocol to eliminate a high percentage of the most obvious errors.





Progress in the Chemistry of Organic Natural Products

Author :

Publisher : Springer Science & Business Media

Page : 325 pages

File Size : 44,81 MB

Release : 2012-12-06

Category : Science

ISBN : 3709169712

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Book Description

The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer imprint ever since the series was founded in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.



Progress in the Chemistry of Organic Natural Products Vol. 94

Author : A. Douglas Kinghorn

Publisher : Springer Science & Business Media

Page : 269 pages

File Size : 17,97 MB

Release : 2011-08-12

Category : Science

ISBN : 3709107482

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Book Description

The three reviews cover the advances in the chemistry and biology of withanolides over the last 16 years, review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.



Progress in the Chemistry of Organic Natural Products 115

Author : A. Douglas Kinghorn

Publisher : Springer Nature

Page : 214 pages

File Size : 33,85 MB

Release : 2021-04-02

Category : Science

ISBN : 3030648532

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Book Description

This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.



Progress in the Chemistry of Organic Natural Products 106

Author : A. Douglas Kinghorn

Publisher : Springer

Page : 309 pages

File Size : 44,58 MB

Release : 2017-07-30

Category : Science

ISBN : 3319595423

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Book Description

The first contribution presents coumarins, the largest group of 1-benzopyran derivatives found in plants. Coumarin chemistry remains one of the major interest areas of phytochemists, especially because of their structural diversity and medicinal properties, along with the wide-ranging bioactivities of these compounds, inclusive of analgesic, anticoagulant anti-HIV, anti-inflammatory, antimicrobial, antineoplastic, antioxidant, and immunomodulatory effects. The second contribution presents a comprehensive survey of the many aspects of PAD biochemistry and physiology. The third contribution gives a comprehensive overview of secondary metabolites from higher fungi, with more than 700 references highlighting the isolation, structure elucidation, biological activities, chemical synthesis, and biosynthesis of pigments, nitrogen-containing compounds, and terpenoids from mushrooms.



Progress in the Chemistry of Organic Natural Products 110

Author : A. Douglas Kinghorn

Publisher : Springer Nature

Page : 274 pages

File Size : 38,26 MB

Release : 2019-10-16

Category : Science

ISBN : 3030146324

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Book Description

The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.



Progress in the Chemistry of Organic Natural Products 101

Author : A. D. Kinghorn

Publisher : Springer

Page : 237 pages

File Size : 31,42 MB

Release : 2015-12-11

Category : Science

ISBN : 3319226924

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Book Description

The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, and H. von Euler-Chelpin. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.



Progress in the Chemistry of Organic Natural Products 102

Author : A. Douglas Kinghorn

Publisher : Springer

Page : 258 pages

File Size : 28,14 MB

Release : 2016-07-05

Category : Science

ISBN : 3319331728

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Book Description

The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.



Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Author :

Publisher : Springer Science & Business Media

Page : 225 pages

File Size : 27,26 MB

Release : 2012-12-06

Category : Science

ISBN : 3709192811

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Book Description

Contents: A.B. Ray and M. Gupta: Withasteroids, a Growing Group of Naturally Occurring Steroidal Lactones. • L. Rodríguez-Hahn, B. Esquivel, and J. Cárdenas: Clerodane Diterpenes in Labiatae. • Author Index. • Subject Index. The volumes of this classic series, now referred to simply as "Zechmeister” after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series’ inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.