Prostaglandins In Bone Resorption


Book Description

First Published in 1988, this book offers a full, comprehensive guide into the process of bone resorption. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Osteology, and other practitioners in their respective fields.













Prostaglandins


Book Description




Bone Regulators and Osteoporosis Therapy


Book Description

This volume is designed to provide an understanding of current and potential therapies for osteoporosis. The opening chapter introduces the cells of bone and their interactions. Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and local mediators including growth factors, prostaglandins, cytokines and chemokines. Topics that have commanded particular attention recently are calcium, FGF-23, nervous system bone interactions. Drugs that cause bone loss provide important information on mechanism as well as therapeutic considerations. An overview of the genetics of bone disorders and a discussion of the pathophysiology of osteoporosis establish the clinical context. The final chapters discuss current and potential osteoporosis treatments.




Anabolic Treatments for Osteoporosis


Book Description

Osteoporosis, a growing epidemic among women in North America, Europe, and Japan, is a painful, costly disease that has presented a treatment challenge to healthcare professionals. Until recently, therapies have focused on agents that slow bone resorption, and have had only limited success at increasing bone mass.




The Influence of Prostaglandins and Other Agents on the Resorption and Synthesis of Mouse Calvarial Bone in Culture


Book Description

Calvaria dissected from 6-day-old mice were maintained in organ culture in a chemically-defined medium without serum additives. Bone resorption was quantified by the release of 45Ca or hydroxyproline (Hyp) into the medium. Collagen synthesis (Hyp) in bone was estimated by the incorporation of [5-3H]-proline. Prostaglandin E2 (PGE2), prostaglandin F (PGF) and 6-keto-prostaglandin F1a (6-keto-PGF1a) released into the medium from cultured calvaria, were measured by radioimmunoassay. Prostanoids were also quantified by the release of radioactively-labelled metabolites from calvaria pre-labelled in vitro with [3H]-arachidonic acid. These metabolites were separated by high performance liquid chromatography.




Principles of Bone Biology


Book Description

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition