Prostaglandins in the Cardiovascular System
Author : Helmut Sinzinger
Publisher : Birkhauser
Page : 402 pages
File Size : 27,78 MB
Release : 1992
Category : Medical
ISBN :
Author : Helmut Sinzinger
Publisher : Birkhauser
Page : 402 pages
File Size : 27,78 MB
Release : 1992
Category : Medical
ISBN :
Author : Karsten Schrör
Publisher : S. Karger AG (Switzerland)
Page : 596 pages
File Size : 28,34 MB
Release : 1985
Category : Medical
ISBN :
Author : John A. Oates
Publisher :
Page : 388 pages
File Size : 18,31 MB
Release : 1982
Category : Appareil cardiovasculaire
ISBN : 9780890045800
Author : Ryszard Gryglewski
Publisher : Springer
Page : 344 pages
File Size : 44,74 MB
Release : 1987
Category : Medical
ISBN :
Ten years after the discovery of prostacyclin, our knowledge of its biochemical mode of action, pharmacological properties, pathophysiological significance and therapeutic applications is ever expanding. Prostacyclin is both complex and unique as demonstrated by its unusual feature of being chemically and meta bolically unstable when compared to other prostanoids and known amine or peptide mediators. Although physiologically essential, the chemical instability of prostacyclin poses a serious drawback in laboratory and clinical studies. It is one of the genuine objectives of pharmaceutical research to supply synthetic compounds which overcome the inherent drawbacks - considering investigational and therapeutic use - of endogenous compounds. Whereas metabolic instability in certain cases could be of advantage, chemical instability definitely is not. With Iloprost, a molecule has been designed which - according to all data so far available - pertains high receptor affinity, metabolic instability (clinically this equates with a fine control of Iloprost's effects) while chemical stability has been achieved. By virtue of these characteristics Iloprost can be considered as one step towards specific interaction within the arachidonic acid cascade, namely the prostacyclin receptor. The aim of the symposium was to provide a critical experimental appraisal concerning the biochemical mode of action and pharmacological properties of prostacyclin and Iloprost.
Author : K. Schrör
Publisher :
Page : 572 pages
File Size : 27,78 MB
Release : 1985
Category :
ISBN :
Author : Karsten Schörr
Publisher : Alan R. Liss
Page : 680 pages
File Size : 49,10 MB
Release : 1989
Category : Medical
ISBN :
Author : Takayuki Ozawa
Publisher : Taylor & Francis Group
Page : 236 pages
File Size : 14,10 MB
Release : 1986
Category : Medical
ISBN :
Author : A. Scriabine
Publisher : Springer
Page : 530 pages
File Size : 47,53 MB
Release : 1980-10-31
Category : Medical
ISBN :
Author : L. David Hillis
Publisher :
Page : 48 pages
File Size : 46,27 MB
Release : 1981
Category :
ISBN :
Author : Bengt Samuelsson
Publisher :
Page : 402 pages
File Size : 26,75 MB
Release : 1982
Category : Cardiovascular system
ISBN :