Protein Turnover


Book Description

This book is concerned with protein metabolism at the physiological, not the molecular level and particularly with studies on human beings. Protein turnover is a vital function, no less important than oxygen turnover, because of this over the last 20 years there has been an increase in the research on protein turnover in man, with parallel work on farm animals. Methods that have been used for measuring whole body protein turnover in man, the underlying problems and assumptions and the problems that have been encountered are discussed in this comprehensive book.




Human Protein Metabolism


Book Description

A succinct review of hundreds of studies on the regulation of protein mass and protein turnover in the human body. The book summarizes the biochemistry of protein synthesis and breakdown, and explains the methods that are used to examine protein metabolism in humans, together with their limitations. Chapters review the effects of nutrition, hormones, metabolic substrates, and physical activity, while various topics of clinical interest include cancer, diabetes, tissue injury, pregnancy, renal disease, muscular dystrophies, and other conditions. Normal values are presented for turnover of proteins in the whole body and individual organs, and for turnover of many individual proteins. This is thus a valuable resource for physiologists, nutritionists, and clinicians interested in the regulation of body protein stores in health and disease. For scientists primarily interested in the basic aspects of protein metabolism, it shows how the basic knowledge is being applied to the study of humans.







Mammalian Protein Metabolism


Book Description

Mammalian Protein Metabolism, Volume I focuses on the processes, methodologies, biosynthesis, protein formation, and reactions involved in mammalian protein metabolism. The selection first elaborates on the origin and growth of concepts of protein metabolism, including the development of nitrogen balance as a technique for the study of protein metabolism; identification of proteins as a chemical class; discovery of nitrogen and its biological consequences; and recognition of the importance of nitrogenous compounds. The text then examines protein digestion and absorption in nonruminants and digestion and absorption of nitrogenous compounds in ruminants. Topics include passage of nitrogenous compounds from the rumen; utilization of nitrogenous compounds in the rumen; and endogenous nitrogen entering the reticulum and rumen. The book examines free amino acids and peptides in tissues, metabolic fate of amino acids, protein biosynthesis in mammalian tissues, and metabolism of plasma proteins. Discussions focus on the distribution of proteins between plasma and lymph, interpretation of plasma radioactivities, amino acid activating enzymes, ribosomes and protein synthesis, pathways of amino acid degradation, and synthesis of urea. The selection is a dependable source of data for researchers interested in mammalian protein metabolism.




Mammalian Protein Metabolism


Book Description

Mammalian Protein Metabolism, Volume IV is an 11-chapter text that describes the regulation of protein metabolism in mammals, both at the subcellular level and at the level of the intact organ and of the whole animal. The first two chapters deal with the fundamental control mechanisms in the synthesis and turnover of proteins, followed by chapters on the mode of action of hormones on protein metabolism and on the role of free amino acid pools in regulation. These topics are followed by discussions on the regulation of individual amino acid pathways and the diurnal rhythms in protein metabolism. The final chapters explore the regulation of protein metabolism in four major organs and tissues of the body, including the gastrointestinal tract, liver, kidney, and musculature. This book will be of great benefit to biologists, researchers, and biology students.










The Role of Protein and Amino Acids in Sustaining and Enhancing Performance


Book Description

It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.