Quantitative Biosciences Companion in MATLAB


Book Description

A hands-on lab guide in the MATLAB programming language that enables students in the life sciences to reason quantitatively about living systems across scales This lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty. Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communities Encourages good coding practices, clear and understandable modeling, and accessible presentation of results Helps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scale Builds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulations Bridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their own Stand-alone computational lab guides for Quantitative Biosciences also available in Python and R




Quantitative Biosciences Companion in R


Book Description

A hands-on lab guide in the R programming language that enables students in the life sciences to reason quantitatively about living systems across scales This lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty. Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communities Encourages good coding practices, clear and understandable modeling, and accessible presentation of results Helps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scale Builds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulations Bridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their own Stand-alone computational lab guides for Quantitative Biosciences also available in Python and MATLAB




Quantitative Biosciences Companion in Python


Book Description

A hands-on lab guide in the Python programming language that enables students in the life sciences to reason quantitatively about living systems across scales This lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty. Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communities Encourages good coding practices, clear and understandable modeling, and accessible presentation of results Helps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scale Builds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulations Bridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their own Stand-alone computational lab guides for Quantitative Biosciences also available in R and MATLAB




So Simple a Beginning


Book Description

A biophysicist reveals the hidden unity behind nature’s breathtaking complexity The form and function of a sprinting cheetah are quite unlike those of a rooted tree. A human being is very different from a bacterium or a zebra. The living world is a realm of dazzling variety, yet a shared set of physical principles shapes the forms and behaviors of every creature in it. So Simple a Beginning shows how the emerging new science of biophysics is transforming our understanding of life on Earth and enabling potentially lifesaving but controversial technologies such as gene editing, artificial organ growth, and ecosystem engineering. Raghuveer Parthasarathy explains how four basic principles—self-assembly, regulatory circuits, predictable randomness, and scaling—shape the machinery of life on scales ranging from microscopic molecules to gigantic elephants. He describes how biophysics is helping to unlock the secrets of a host of natural phenomena, such as how your limbs know to form at the proper places, and why humans need lungs but ants do not. Parthasarathy explores how the cutting-edge biotechnologies of tomorrow could enable us to alter living things in ways both subtle and profound. Featuring dozens of original watercolors and drawings by the author, this sweeping tour of biophysics offers astonishing new perspectives on how the wonders of life can arise from so simple a beginning.




Nano Comes to Life


Book Description

"Increasingly, scientists are gaining control over matter at the nanometer scale. Spearheaded by physical scientists operating at the interfaces of physics and biology (such as the author herself), advances in nanoscience and technology are transforming how we think about life and treat human health. This is due to a convergence of size. To do medicine, one must understand and be able to reach the nanoscale environment of healthy cells in tissues and organs, as well as other nano-sized building blocks that constitute a living organism, such as proteins and DNA. The ground-breaking advances being made at the frontiers of nanoscience and -technology, specifically in the areas of biology and medicine, are the subject of this short, popular-level book. Chapter 1 describes how nanotechnology and quantitative methods in biology are progressively being deployed to embrace life in all its multiscale, hierarchical intricacy and multiplicity. Chapters 2 through 4 review how bioinspired and biomimetic nanostructures and nanomachines are being created and integrated into strategies aimed at solving specific medical problems. In particular, Chapter 2 summarizes how scientists are seeking to build artificial nanostructures using both biological molecules and the organizational principles of biology. Chapter 3 gives an account of how nanotechnology is being used to develop drug-delivery strategies that specifically target cancer cells and tumors to improve the efficacy of current cancer chemotherapies. Chapter 4 reviews the science of one of the most potentially transformative scientific fields: tissue engineering. In a concluding chapter (Chapter 5), Contera reviews how nanotechnology, biology, and medicine will continue fusing with other sciences and technologies - incorporating more mathematical and computational modelling, as well as AI and robotics. Nanoscale devices will be used to learn biology; and biology will be used to inspire increasingly sophisticated "transmaterial" devices that mimic some of the characteristics of biology and incorporate new features that are not available in the biological world. The effects on human health and longevity will be profound. In a more personal epilogue, Contera describes the crossroads at which we find ourselves. Accessing our own biology evokes a mixture of possibility and dread. However, Contera maintains that we can create a positive transmaterial world for the benefit of humankind, and she describes ways in which scientists are proactively engaging with the public, politicians, industry, and entrepreneurs, as well as the media and the arts, to communicate the power and risks of new advances and to influence the ways in which new technologies will affect our future"--




Solid Biomechanics


Book Description

Offering a review of the biomechanical design of organisms, from bacteria onwards, this book shows how the bodies of animals & plants are masterpieces of engineering, enabling them to survive in a hostile world.




Biophysics


Book Description

A physicist's guide to the phenomena of life Interactions between the fields of physics and biology reach back over a century, and some of the most significant developments in biology—from the discovery of DNA's structure to imaging of the human brain—have involved collaboration across this disciplinary boundary. For a new generation of physicists, the phenomena of life pose exciting challenges to physics itself, and biophysics has emerged as an important subfield of this discipline. Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students. Bialek begins by exploring how photon counting in vision offers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. He draws from these lessons three general physical principles—the importance of noise, the need to understand the extraordinary performance of living systems without appealing to finely tuned parameters, and the critical role of the representation and flow of information in the business of life. Bialek then applies these principles to a broad range of phenomena, including the control of gene expression, perception and memory, protein folding, the mechanics of the inner ear, the dynamics of biochemical reactions, and pattern formation in developing embryos. Featuring numerous problems and exercises throughout, Biophysics emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems. Covers a range of biological phenomena from the physicist's perspective Features 200 problems Draws on statistical mechanics, quantum mechanics, and related mathematical concepts Includes an annotated bibliography and detailed appendixes




The R Book


Book Description

The high-level language of R is recognized as one of the mostpowerful and flexible statistical software environments, and israpidly becoming the standard setting for quantitative analysis,statistics and graphics. R provides free access to unrivalledcoverage and cutting-edge applications, enabling the user to applynumerous statistical methods ranging from simple regression to timeseries or multivariate analysis. Building on the success of the author’s bestsellingStatistics: An Introduction using R, The R Book ispacked with worked examples, providing an all inclusive guide to R,ideal for novice and more accomplished users alike. The bookassumes no background in statistics or computing and introduces theadvantages of the R environment, detailing its applications in awide range of disciplines. Provides the first comprehensive reference manual for the Rlanguage, including practical guidance and full coverage of thegraphics facilities. Introduces all the statistical models covered by R, beginningwith simple classical tests such as chi-square and t-test. Proceeds to examine more advance methods, from regression andanalysis of variance, through to generalized linear models,generalized mixed models, time series, spatial statistics,multivariate statistics and much more. The R Book is aimed at undergraduates, postgraduates andprofessionals in science, engineering and medicine. It is alsoideal for students and professionals in statistics, economics,geography and the social sciences.




Einstein's Other Theory


Book Description

Einstein's theories of relativity piqued public curiosity more than any other mathematical concepts since the time of Isaac Newton. Scientists and non-scientists alike struggled, not so much to grasp as to believe the weird predictions of relativity theory--shrinking space ships, bending light beams, and the like. People all over the world watched with fascination as Einstein's predictions were relentlessly and unequivocally verified by a hundred experiments and astronomical observations. In the last decade of the twentieth-century, another of Einstein's theories has produced results that are every bit as startling as the space-time contractions of relativity theory. This book addresses his other great theory, that of heat capacity and the Bose-Einstein condensate. In doing so, it traces the history of radiation and heat capacity theory from the mid-19th century to the present. It describes early attempts to understand heat and light radiation and proceeds through the theory of the heat capacity of solids. It arrives at the theory of superconductivity and superfluidity--the astonishing property of some liquids to crawl spontaneously up and out of their containers, and the ability of some gases to cause light to pause and take a moment's rest from its inexorable flight forward in time. Couched in the terminology of traditional physical chemistry, this book is accessible to chemists, engineers, materials scientists, mathematicians, mathematical biologists, indeed to anyone with a command of first-year calculus. In course work, it is a collateral text to third semester or advanced physical chemistry, introductory statistical mechanics, statistical thermodynamics, or introductory quantum chemistry. The book connects with mainstream physical chemistry by treating boson and fermion influences in molecular spectroscopy, statistical thermodynamics, molecular energetics, entropy, heat capacities (especially of metals), superconductivity, and superfluidity.




Kinetics of Heterogeneous Catalytic Reactions


Book Description

This book is a critical account of the principles of the kinetics of heterogeneous catalytic reactions in the light of recent developments in surface science and catalysis science. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.