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Quantitative Methods in Pharmaceutical Research and Development

Author : Olga V. Marchenko

Publisher : Springer Nature

Page : 445 pages

File Size : 14,50 MB

Release : 2020-09-24

Category : Medical

ISBN : 3030485552

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Book Description

This contributed volume presents an overview of concepts, methods, and applications used in several quantitative areas of drug research, development, and marketing. Chapters bring together the theories and applications of various disciplines, allowing readers to learn more about quantitative fields, and to better recognize the differences between them. Because it provides a thorough overview, this will serve as a self-contained resource for readers interested in the pharmaceutical industry, and the quantitative methods that serve as its foundation. Specific disciplines covered include: Biostatistics Pharmacometrics Genomics Bioinformatics Pharmacoepidemiology Commercial analytics Operational analytics Quantitative Methods in Pharmaceutical Research and Development is ideal for undergraduate students interested in learning about real-world applications of quantitative methods, and the potential career options open to them. It will also be of interest to experts working in these areas.



Pharmacy Practice Research Methods

Author : Zaheer-Ud-Din Babar

Publisher : Springer

Page : 251 pages

File Size : 24,82 MB

Release : 2015-03-25

Category : Medical

ISBN : 3319146726

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Book Description

This book presents a contemporary view of pharmacy practice research covering theories, methodologies, models and techniques that are applicable. It has thirteen chapters covering the range of quantitative, qualitative, action research and mixed methods as well as management theories underpinning change in pharmacy practice. “Pharmacy Practice Research Methods” examines the evidence and impact as well as explores the future. Pharmacy practice is rapidly transforming and as such it is to be adaptable as student and academic researchers and to not only understand techniques and methodologies, but as champions to nurture the field. There is a literature in this area but few integrated texts which cover the wide range of pharmacy practice including methodologies, evidence, practice and policy. This book provides a solid foundation for exploring these phenomenon further, and is expected to serve as a valuable resource for academics, students, policy makers and professional organisations.



Colloid and Interface Science in Pharmaceutical Research and Development

Author : Hiroyuki Ohshima

Publisher : Elsevier

Page : 533 pages

File Size : 28,71 MB

Release : 2014-07-23

Category : Technology & Engineering

ISBN : 0444626085

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Book Description

Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs. - Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development - Explains the physicochemical/colloidal basis of pharmaceutical science - Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data - Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail



Contemporary Research Methods in Pharmacy and Health Services

Author : Shane P. Desselle

Publisher : Academic Press

Page : 672 pages

File Size : 18,69 MB

Release : 2022-05-10

Category : Medical

ISBN : 0323914268

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Book Description

Emerging methods, as well as best practices in well-used methods, in pharmacy are of great benefit to researchers, graduate students, graduate programs, residents and fellows also in other health science areas. Researchers require a text to assist in the design of experiments to address seemingly age-old problems. New interventions are needed to improve medication adherence, patients' lived experiences in health care, provider-patient relationships, and even various facets of pharmacogenomics. Advances in systems re-engineering can optimize health care practitioners' roles. Contemporary Research Methods in Pharmacy and Health Services includes multi-authored chapters by renowned experts in their field. Chapters cover examples in pharmacy, health services and others transcendent of medical care, following a standardized format, including key research points; valid and invalid assumptions; pitfalls to avoid; applications; and further inquiry. This is a valuable resource for researchers both in academia and corporate R&D, primarily in pharmacy but also in health services, and other health disciplines. Social science researchers and government scientists can also benefit from the reading. - Provides multi-authored chapters by renowned experts in their field - Includes examples for pharmacy and health services and others that are transcendent of medical care - Covers key research points, valid and invalid assumptions, pitfalls to avoid, applications, and further inquiry



Computer Applications in Pharmaceutical Research and Development

Author : Sean Ekins

Publisher : John Wiley & Sons

Page : 840 pages

File Size : 44,96 MB

Release : 2006-07-11

Category : Medical

ISBN : 0470037229

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Book Description

A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: * Computers in pharmaceutical research and development: a general overview * Understanding diseases: mining complex systems for knowledge * Scientific information handling and enhancing productivity * Computers in drug discovery * Computers in preclinical development * Computers in development decision making, economics, and market analysis * Computers in clinical development * Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.



Research and Development in the Pharmaceutical Industry (A CBO Study)

Author : Congressional Budget Office

Publisher : Lulu.com

Page : 65 pages

File Size : 24,31 MB

Release : 2013-06-09

Category : Science

ISBN : 1304121445

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Book Description

Perceptions that the pace of new-drug development has slowed and that the pharmaceutical industry is highly profitable have sparked concerns that significant problems loom for future drug development. This Congressional Budget Office (CBO) study-prepared at the request of the Senate Majority Leader-reviews basic facts about the drug industry's recent spending on research and development (R&D) and its output of new drugs. The study also examines issues relating to the costs of R&D, the federal government's role in pharmaceutical research, the performance of the pharmaceutical industry in developing innovative drugs, and the role of expected profits in private firms' decisions about investing in drug R&D. In keeping with CBO's mandate to provide objective, impartial analysis, the study makes no recommendations. David H. Austin prepared this report under the supervision of Joseph Kile and David Moore. Colin Baker provided valuable consultation...



Benefit-Risk Assessment in Pharmaceutical Research and Development

Author : Andreas Sashegyi

Publisher : CRC Press

Page : 216 pages

File Size : 26,8 MB

Release : 2013-11-27

Category : Mathematics

ISBN : 143986795X

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Book Description

Many practitioners in the pharmaceutical industry are still largely unfamiliar with benefit-risk assessment, despite its growing prominence in drug development and commercialization. Helping to alleviate this knowledge gap, Benefit-Risk Assessment in Pharmaceutical Research and Development provides a succinct overview of the key considerations rele



Analytical Techniques in the Pharmaceutical Sciences

Author : Anette Müllertz

Publisher : Springer

Page : 829 pages

File Size : 34,18 MB

Release : 2016-08-30

Category : Medical

ISBN : 1493940295

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Book Description

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.



Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment

Author : Kunal Roy

Publisher : Academic Press

Page : 494 pages

File Size : 43,71 MB

Release : 2015-03-03

Category : Medical

ISBN : 0128016337

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Book Description

Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment describes the historical evolution of quantitative structure-activity relationship (QSAR) approaches and their fundamental principles. This book includes clear, introductory coverage of the statistical methods applied in QSAR and new QSAR techniques, such as HQSAR and G-QSAR. Containing real-world examples that illustrate important methodologies, this book identifies QSAR as a valuable tool for many different applications, including drug discovery, predictive toxicology and risk assessment. Written in a straightforward and engaging manner, this is the ideal resource for all those looking for general and practical knowledge of QSAR methods. - Includes numerous practical examples related to QSAR methods and applications - Follows the Organization for Economic Co-operation and Development principles for QSAR model development - Discusses related techniques such as structure-based design and the combination of structure- and ligand-based design tools



Structure-Based Drug Design

Author : Pandi Veerapandian

Publisher : Routledge

Page : 665 pages

File Size : 13,53 MB

Release : 2018-03-29

Category : Medical

ISBN : 1351413066

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Book Description

Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!