Quinine's Predecessor


Book Description

The history of cinchona has traditionally begun with the romantic - and now discredited - story of Francisca Henriquez Ribera, the Countess of Chinchon. According to legend, the Countess became seriously ill during an outbreak of fever in Lima around 1623. Her husband, the Viceroy, learning of a medicinal tree bark used by the local Indians, ordered the bark tested and administered to his wife. Following her prompt recovery, the Countess championed the use of bark among the general populace, and thousands of lives were saved. The drug became known as pulvis Comitissae, the powder of the Countess, and later - misspelled by Linnaeus - as cinchona. In Quinine's Predecessor Saul Jarcho unravels a tangle of myth, hearsay, and fact to establish the definitive history of cinchona bark - the still-important source of modern quinine. Jarcho explains the discovery of the healing property of the substance, also known as Peruvian bark or Jesuits' bark, and traces the routes by which it was transmitted from South America to Spain and other countries. He recounts the controversy and resistance surrounding its acceptance by medical practitioners. And he offers the most complete account to date of the important work of Francesco Torti, who used the bark successfully in treating cerebral and other especially dangerous malarial infections.




War and Disease


Book Description

Malaria is one of the leading killers in the world today. Though drugs against malaria have a long history, attempts to develop novel therapeutics spanned the twentieth century and continue today. In this historical study, Leo B. Slater shows the roots and branches of an enormous drug development project during World War II. Fighting around the globe, American soldiers were at high risk for contracting malaria, yet quinine–a natural cure–became harder to acquire. A U.S. government-funded antimalarial program, initiated by the National Research Council, brought together diverse laboratories and specialists to provide the best drugs to the nation's military. This wartime research would deliver chloroquinine–long the drug of choice for prevention and treatment of malaria–and a host of other chemotherapeutic insights. A massive undertaking, the antimalarial program was to biomedical research what the Manhattan Project was to the physical sciences. A volume in the Critical Issues in Health and Medicine series, edited by Rima D. Apple and Janet Golden.







Antimalarial Chemotherapy


Book Description

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.




Drugs on Trial


Book Description

This book describes the main issues of eighteenth-century pharmacology and therapeutics and provides detailed case studies of three key areas: lithontriptics (remedies against urinary stones), opium, and Peruvian bark (quinine).




Robert Burns Woodward


Book Description

Robert Burns Woodward was the star of 20th-century organic chemistry. An MIT graduate by age 19, Woodward's ingenious notions about organic synthesis and his artful methodology were astounding. He is most famed for his synthesis of vitamin B12,which he undertook with Albert Eschenmoser, and for the orbital symmetry rules he developed with Roald Hoffmann. This volume presents Woodward's most celebrated papers and lectures--including the famous Cope lecture. Insightful commentaries and rarely seen photographs are also included.




Malarial Subjects


Book Description

Malaria was considered one of the most widespread disease-causing entities in the nineteenth century. It was associated with a variety of frailties far beyond fevers, ranging from idiocy to impotence. And yet, it was not a self-contained category. The reconsolidation of malaria as a diagnostic category during this period happened within a wider context in which cinchona plants and their most valuable extract, quinine, were reinforced as objects of natural knowledge and social control. In India, the exigencies and apparatuses of British imperial rule occasioned the close interactions between these histories. In the process, British imperial rule became entangled with a network of nonhumans that included, apart from cinchona plants and the drug quinine, a range of objects described as malarial, as well as mosquitoes. Malarial Subjects explores this history of the co-constitution of a cure and disease, of British colonial rule and nonhumans, and of science, medicine and empire. This title is also available as Open Access.




Traditional Medicinal Plants and Malaria


Book Description

Malaria is an increasing worldwide threat, with more than three hundred million infections and one million deaths every year. The worlds poorest are the worst affected, and many treat themselves with traditional herbal medicines. These are often more available and affordable, and sometimes are perceived as more effective than conventional antimala




Chemist and Druggist


Book Description




Saving Lives, Buying Time


Book Description

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.