Recent Progress in Coalescent Theory
Author : Nathanaël Berestycki
Publisher :
Page : 193 pages
File Size : 48,10 MB
Release : 2009
Category : Aggregation (Chemistry)
ISBN : 9788585818401
Handbook of Statistical Genomics
Author : David J. Balding
Publisher : John Wiley & Sons
Page : 1740 pages
File Size : 15,36 MB
Release : 2019-07-09
Category : Science
ISBN : 1119429250
Book Description
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.
Advances in Disordered Systems, Random Processes and Some Applications
Author : Pierluigi Contucci
Publisher : Cambridge University Press
Page : 383 pages
File Size : 38,61 MB
Release : 2017
Category : Science
ISBN : 1107124107
Book Description
This book offers a unified perspective on the study of complex systems with contributions written by leading scientists from various disciplines, including mathematics, physics, computer science, biology, economics and social science. It is written for researchers from a broad range of scientific fields with an interest in recent developments in complex systems.
Gene Genealogies, Variation and Evolution: A primer in coalescent theory
Author : Jotun Hein
Publisher : Oxford University Press, USA
Page : 298 pages
File Size : 10,63 MB
Release : 2004-12-09
Category : Population genetics
ISBN : 9780191546150
Book Description
Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. - Professor Montgomery Slatkin (Berkeley);the authors are outstanding experts in the field, and the book is topical and timely. - Professor David Balding (Imperial College);Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. - Professor Joe Felsenstein (University of Washington)
Statistics in Genetics
Author : M.Elizabeth Halloran
Publisher : Springer Science & Business Media
Page : 268 pages
File Size : 42,28 MB
Release : 1999-06-04
Category : Medical
ISBN : 9780387988283
Book Description
Though the Genome Project will eventually result in the sequencing of the human genome, as well as the genomes of several other organisms, there will still be a need for good statistics for family studies of complex diseases. The papers in this volume are contributions by some of the leading researchers in the field to the current topics in statistical genetics. One section deals with DNA sequence matching and issues related to forensics, while another deals with statistical problems of modeling phylogenies and inferential difficulties related to the complex tree structures produced, as well as the method of coalescence.
Handbook of Statistical Genomics
Author : David J. Balding
Publisher : John Wiley & Sons
Page : 1219 pages
File Size : 50,42 MB
Release : 2019-07-02
Category : Science
ISBN : 1119429226
Book Description
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.
Partitions, Hypergeometric Systems, and Dirichlet Processes in Statistics
Author : Shuhei Mano
Publisher : Springer
Page : 140 pages
File Size : 43,33 MB
Release : 2018-07-12
Category : Mathematics
ISBN : 4431558888
Book Description
This book focuses on statistical inferences related to various combinatorial stochastic processes. Specifically, it discusses the intersection of three subjects that are generally studied independently of each other: partitions, hypergeometric systems, and Dirichlet processes. The Gibbs partition is a family of measures on integer partition, and several prior processes, such as the Dirichlet process, naturally appear in connection with infinite exchangeable Gibbs partitions. Examples include the distribution on a contingency table with fixed marginal sums and the conditional distribution of Gibbs partition given the length. The A-hypergeometric distribution is a class of discrete exponential families and appears as the conditional distribution of a multinomial sample from log-affine models. The normalizing constant is the A-hypergeometric polynomial, which is a solution of a system of linear differential equations of multiple variables determined by a matrix A, called A-hypergeometric system. The book presents inference methods based on the algebraic nature of the A-hypergeometric system, and introduces the holonomic gradient methods, which numerically solve holonomic systems without combinatorial enumeration, to compute the normalizing constant. Furher, it discusses Markov chain Monte Carlo and direct samplers from A-hypergeometric distribution, as well as the maximum likelihood estimation of the A-hypergeometric distribution of two-row matrix using properties of polytopes and information geometry. The topics discussed are simple problems, but the interdisciplinary approach of this book appeals to a wide audience with an interest in statistical inference on combinatorial stochastic processes, including statisticians who are developing statistical theories and methodologies, mathematicians wanting to discover applications of their theoretical results, and researchers working in various fields of data sciences.
Branching Processes and Their Applications
Author : Inés M. del Puerto
Publisher : Springer
Page : 331 pages
File Size : 20,83 MB
Release : 2016-09-06
Category : Mathematics
ISBN : 3319316419
Book Description
This volume gathers papers originally presented at the 3rd Workshop on Branching Processes and their Applications (WBPA15), which was held from 7 to 10 April 2015 in Badajoz, Spain (http://branching.unex.es/wbpa15/index.htm). The papers address a broad range of theoretical and practical aspects of branching process theory. Further, they amply demonstrate that the theoretical research in this area remains vital and topical, as well as the relevance of branching concepts in the development of theoretical approaches to solving new problems in applied fields such as Epidemiology, Biology, Genetics, and, of course, Population Dynamics. The topics covered can broadly be classified into the following areas: 1. Coalescent Branching Processes 2. Branching Random Walks 3. Population Growth Models in Varying and Random Environments 4. Size/Density/Resource-Dependent Branching Models 5. Age-Dependent Branching Models 6. Special Branching Models 7. Applications in Epidemiology 8. Applications in Biology and Genetics Offering a valuable reference guide to contemporary branching process theory, the book also explores many open problems, paving the way for future research.
Evolutionary Biology
Author : Pierre Pontarotti
Publisher : Springer
Page : 412 pages
File Size : 40,37 MB
Release : 2016-09-20
Category : Science
ISBN : 3319413244
Book Description
This book presents selected contributions to the 19th Evolutionary Biology Meeting, which took place in September 2015 in Marseille. It consists of 22 chapters, which are grouped in four sections: · Convergent Evolution · Evolution of Complex Traits · Concepts · Methods The annual Evolutionary Biology Meetings in Marseille serve to gather leading evolutionary biologists and other scientists using evolutionary biology concepts, e.g for medical research, to promote the exchange of ideas and to encourage interdisciplinary collaborations. Offering an up-to-date overview of recent findings in the field of evolutionary biology, this book is an invaluable source of information for scientists, teachers and advanced students.
Genealogies of Interacting Particle Systems
Author : Matthias Birkner
Publisher : World Scientific
Page : 363 pages
File Size : 49,76 MB
Release : 2020
Category : Biomathematics
ISBN : 9811206090
Book Description
"Interacting particle systems are Markov processes involving infinitely many interacting components. Since their introduction in the 1970s, researchers have found many applications in statistical physics and population biology. Genealogies, which follow the origin of the state of a site backwards in time, play an important role in their studies, especially for the biologically motivated systems. The program Genealogies of Interacting Particle Systems held at the Institute for Mathematical Sciences, National University of Singapore, from 17 July to 18 Aug 2017, brought together experts and young researchers interested in this modern topic. Central to the program were learning sessions where lecturers presented work outside of their own research, as well as a normal workshop "--Publisher's website.
