Author : Ellen Heber-Katz
Publisher : Springer Science & Business Media
Page : 202 pages
File Size : 10,44 MB
Release : 2012-12-06
Category : Science
ISBN : 364218846X
In this issue of Current Topics in Microbiology and Immunology the authors present a unique range of examples of the regenerative response and the role of stem cells from the amphibian to human. It seems that all roads lead to cells that have the plasticity to become something else, not only in the amphibian but also in the mammal.
Author : Felix B Engel
Publisher : World Scientific
Page : 393 pages
File Size : 32,57 MB
Release : 2012-03-22
Category : Medical
ISBN : 9814465259
Injured mammalian hearts do not regenerate but scar. This is a major medical problem, as ischemic heart disease is among the leading causes of morbidity and mortality worldwide. Essential clues for human heart repair are uncovered when zebrafish and newt are found to regenerate cardiac muscle after injury.This book presents the major advances of the last decade in the field of cardiac regeneration. These recent advances include: demonstration that zebrafish, a genetically tractable system, can regenerate heart; the identification of several new stem cell populations in the heart; demonstration that stem cells can be used to improve heart function; and demonstration that induction of cardiomyocyte proliferation is a realistic future option to repair injured hearts. This book also provides detailed reviews of the research on model organisms capable of heart regeneration as well as innovative translational research to achieve regeneration in mammals, that comprises work on blood born stem cells, endogenous cardiac stem cells, paracrine factors, reawakening of cardiomyocyte proliferation, and bioengineering. More importantly, the book, in the concluding chapter, dovetails the studies with a comprehensive overview of clinical trials.
Author : Kristina Hug
Publisher : Springer Science & Business Media
Page : 463 pages
File Size : 12,70 MB
Release : 2010-12-25
Category : Science
ISBN : 1607619598
For many years, the ethical discussion surrounding human embryonic stem cell research has focused on the moral status of the embryo. This text takes a wider moral berth and focuses on numerous ethical, legal and social aspects involved in translating the results of stem cell research into diagnostic and therapeutic applications. Translational Stem Cell Research is broken into ten sections. It opens with an overview of the latest in stem cell research, focusing on specific diseases and the treatment of burn victims. Part II discusses the issues involved in the many steps from bench to bedside, ranging from first research in vitro to clinical trials. Part III covers scientific, regulatory and ethical challenges to basic research, and Part IV details issues regarding stem cell banks. Part V explores ethical, economic and strategic issues involved in collaboration between universities and industry, and Part VI addresses legal problems raised by patents on human stem-cell based inventions plus the extent to which there can be technological solutions to a moral dilemma. Part VII presents imaginative ways of communicating research to the general public and how to create conditions for a constructive dialogue. Part VIII probes psychosocial and cultural factors affecting judgment and decisions about translational stem cell research, and Part IX explores problems and procedures raised by an examination of the evaluation of stem cell research projects in research ethics committees. The book closes with a look into the future of translational stem cell research and stem cell-based therapeutic applications.
Author : D. O. N. C. REED
Publisher : World Scientific
Page : 440 pages
File Size : 23,71 MB
Release : 2015-10-06
Category : Medical
ISBN : 9814618284
This is a one-of-a-kind book: combining easy-to-understand science, in-the-trenches political warfare, and inspirational stories. It aims to give hope to individuals and families who suffer from chronic disease or disability; to point out how ordinary people can make an extraordinary difference in the battle to ease suffering and save lives through supporting medical research; to share in "people talk" some of the amazing progress already achieved in the new field of stem cell research; to show how even such a magnificent success as the California stem cell program is under constant attack from ideological groups; to offer medical research as a force for international cooperation; to suggest how cure research lessens the need for the mountainous costs of endless care.Unparalleled background: the author has been involved in virtually every important stem cell battle (state, national, and international) since embryonic stem cell research began. The author works closely with Robert N. Klein, sponsor of the California stem cell program, the largest source of such stem cell research funding in the world. In addition, the author is an award-winning teacher as well as writer, and seeks to entertain as well as educate. His book is not only substantive, but also fun.The book would be a treasured gift: for anyone suffering an "incurable" illness or who is a caregiver for a loved one; for a college student considering a rewarding career in biomedicine; for scientists who want to protect and enhance their research funding; and for anyone who wants to see government respond to the needs of its citizenry. Chronic disease and disability are a prison: cure is the triumphant escape -- wheelchairs should be for temporary occupancy only.
Author : Dmitry Arbuck
Publisher :
Page : pages
File Size : 24,15 MB
Release : 2022-06-15
Category :
ISBN : 9781734123739
Stem cell science is one of the most misunderstood areas of modern medicine. It is surrounded by myths, confusion, and strong opinions that vary from blind belief to complete rejection. This book was written as a review of the developing field with the goal of giving interested doctors and patients a foundation of future fluency. It addresses existing controversies and identifies possible roads to the practical use of stem cells, exosomes, and the active ingredients they synthesize and carry. Readers will learn that modern stem cell treatments are not about embryos, cancer, or the other things they may have been afraid of in the past.The history of stem cell use, the nature of regenrative biologics, and the possible risks and benefits of regenerative medicine are reviewed. The ways the stem cell industry is regulated, the safeguards in place, and how current research is reported are all covered. You will learn that there are many types of stem cell products available and that they differ deeply. We will examine PRP, amniotic fluid, amniotic membrane, fat and bone marrow stem cells, umbilical blood and wall stem cells, and adult stem cells. We also look at exosomes and cell-to-cell interactions. This Third Edition adds updated content and many new and expanded chapters, including regulatory environment changes and other topics.Stem cell science is rich in discoveries, curiosities, possibilities, and pitfalls. There are thousands of studies going on in the US and around the world. Stem Cell treatment holds incredible promise, which may be realized only with diligent research. Neither excessive optimism nor unwarranted pessimism is welcome in medicine. We are at the beginning of a healthcare revolution that will utilize many ways to treat diseases. Stem cell related regenerative treatment is one of these ways to improve life.
Author : Peter Hollands
Publisher : Bentham Science Publishers
Page : 126 pages
File Size : 27,68 MB
Release : 2020-12-03
Category : Health & Fitness
ISBN : 981148211X
The Regeneration Promise is a reader-friendly guide to the world of regenerative medicine and stem cell technology. It covers the history of stem cell technology as a general introduction to the subject and then continues with a description of the many known types of stem cells and how these can potentially be used to treat disease. The author explains the pros and cons of using stem cell technology to treat patients in simple and factual terms throughout the book while clarifying many stem cell myths. There is valuable advice for people considering undergoing stem cell therapy and also for those who are considering stem cell storage such as umbilical cord blood storage at the birth of a baby. The book also covers information on current research in stem cell technology and how this may be useful in the clinic, as promising regenerative medicine treatments emerge in the near future. The simple use of language with a clear explanation of scientific terms, where applicable, makes this book an accessible source of information for anyone interested in enhancing their general knowledge about regenerative medicine when considering such treatment options and understanding the debate surrounding stem cell technology and its use in disease therapy.
Author : Phuc Van Pham
Publisher : Springer
Page : 316 pages
File Size : 25,1 MB
Release : 2017-01-24
Category : Science
ISBN : 3319401440
This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.
Author : Michelle Ariana Wedemeyer
Publisher :
Page : 198 pages
File Size : 10,45 MB
Release : 2012
Category :
ISBN : 9781267346216
Populations of cells were obtained from a clinic offering "treatments" for chronic spinal cord injury. Immunostaining and flow cytometry confirmed the populations to be neural and mesenchymal stem cells, respectively (NSCs and MSCs). ELISAs performed on conditioned media detected several growth factors although neurotrophic factors known to promote regeneration in the spinal cord were not detected. Treatment of primary cortical neurons with media conditioned by MSCs and NSCs did not lead to a statistically significant increase in axon length or complexity. A statistically significant increase in cell number was detected in cultures treated with NSC-conditioned media. In vitro analysis does not support the clinic's claim that the cells exhibit properties which would promote axon growth. Two human embryonic stem cell lines (ES) and three induced pluripotent stem cell lines (iPS) were differentiated into high purity populations of neuronal progenitor cells (NPCs) and oligodendrocyte progenitor cells (OPCs). Both ES and two of three iPS lines produced high purity populations of the desired lineage. Transplantation of OPCs generated from ES and iPS lines into spinal cord injured rats resulted in engraftment of human oligodendrocytes without formation of tumors. We conclude that iPS cells may be adapted to protocols developed for generation of high purity NPCs and OPCs from ES cells. Immature astrocytes are known to promote recovery from spinal cord injury. In order to determine properties of immature astrocytes which promote recovery after spinal cord injury an in vitro model of aged astrocytes was developed. As compared to aged astrocytes, a greater proportion of immature astrocytes are proliferating, express more laminin, are motile, and promote greater regeneration of dorsal root ganglion (DRG) axons. Reprogramming mature astrocytes into immature astrocytes is a potential therapy for chronic spinal cord injury. Nine factors which are expressed at higher levels in immature versus mature astrocytes were overexpressed in aged astrocytes. At two weeks, treated cultures exhibited greater laminin immunofluorescence, increased capacity to promote growth of adult DRG axons, and foci of increased motility mixed with foci of cell death. Treatment of aged astrocytes with 9 factors leads to partial recovery of immature properties.
Author : Ngan Huang
Publisher : World Scientific
Page : 567 pages
File Size : 24,23 MB
Release : 2017-11-24
Category : Science
ISBN : 9813147768
Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary.This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs, including cardiovascular, musculoskeletal, neurological and skin tissues. The technology platforms for studying and engineering stem cells, such as hydrogel and biomaterials development, microfluidics system and microscale patterning, are also illustrated. Regulatory challenges and quality control for clinical translation are also detailed. This book provides an comprehensive update on the advancement in the field of stem cells and regenerative medicine, and serves as a valuable resource for both researchers and students.
Author : Mary Clarke
Publisher : Garland Science
Page : 966 pages
File Size : 44,90 MB
Release : 2020-07-27
Category : Science
ISBN : 1000062651
Stem cell science, encompassing basic biology to practical application, is both vast and diverse. A full appreciation of it requires an understanding of cell and molecular biology, tissue structure and physiology, the practicalities of tissue engineering and bioprocessing, and the pathways to clinical implementation—including the ethical and regulatory imperatives that our society requires us to address. Expectation and debate have been driven by the allure of regenerative medicine using stem cells as a source of replacements for damaged or aged tissues. The potential of stem cell application goes far beyond this. Highly innovative uses of stem cells are emerging as possible therapies for cancers, treating acute damage in conditions such as stroke and myocardial infarction, and resolving a whole range of diseases. Stem Cells: Biology and Application presents the basic concepts underlying the fast-moving science of stem cell biology. This textbook is written for an advanced stem cell biology course. The target audience includes senior undergraduates, first year graduate students, and practitioners in molecular biology, biology, and biomedical engineering. Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field.
