Planning Clinical Research


Book Description

Planning clinical research requires many decisions. The authors of this book explain key decisions with examples showing what works and what does not.




Timing and Time Perception: Procedures, Measures, & Applications


Book Description

Timing and Time Perception: Procedures, Measures, and Applications is a one-of-a-kind, collective effort to present the most utilized and known methods on timing and time perception. Specifically, it covers methods and analysis on circadian timing, synchrony perception, reaction/response time, time estimation, and alternative methods for clinical/developmental research. The book includes experimental protocols, programming code, and sample results and the content ranges from very introductory to more advanced so as to cover the needs of both junior and senior researchers. We hope that this will be the first step in future efforts to document experimental methods and analysis both in a theoretical and in a practical manner. Contributors are: Patricia V. Agostino, Rocío Alcalá-Quintana, Fuat Balcı, Karin Bausenhart, Richard Block, Ivana L. Bussi, Carlos S. Caldart, Mariagrazia Capizzi, Xiaoqin Chen, Ángel Correa, Massimiliano Di Luca, Céline Z. Duval, Mark T. Elliott, Dagmar Fraser, David Freestone, Miguel A. García-Pérez, Anne Giersch, Simon Grondin, Nori Jacoby, Florian Klapproth, Franziska Kopp, Maria Kostaki, Laurence Lalanne, Giovanna Mioni, Trevor B. Penney, Patrick E. Poncelet, Patrick Simen, Ryan Stables, Rolf Ulrich, Argiro Vatakis, Dominic Ward, Alan M. Wing, Kieran Yarrow, and Dan Zakay.




Assessment of Cancer Screening


Book Description

Cancer screening is a prominent strategy in cancer control in the United States, yet the ability to correctly interpret cancer screening data eludes many researchers, clinicians, and policy makers. This open access primer rectifies that situation by teaching readers, in simple language and with straightforward examples, why and how the population-level cancer burden changes when screening is implemented, and how we assess whether that change is of benefit. This book provides an in-depth look at the many aspects of cancer screening and its assessment, including screening phenomena, performance measures, population-level outcomes, research designs, and other important and timely topics. Concise, accessible, and focused, Assessment of Cancer Screening: A Primer is best suited to those with education or experience in clinical research or public health in the United States - no previous knowledge of cancer screening assessment is necessary. This is the first text dedicated to cancer screening theory and methodology to be published in 20 years.




Prospective Memory


Book Description

Devoted exclusively to prospective memory, this volume organizes the research and thoughts of the important contributors to the field in one comprehensive resource. The chapter authors not only focus on their own work, but also review other research areas and address those where the methods and theories from the retrospective memory literature are useful and where they fall short. Each section is followed by at least one commentary written by a prominent scholar in the field of memory. The commentators present critical analyses of the chapters, note ideas that they found particularly exciting, and use these ideas as a foundation on which to elaborate their own views of prospective memory. This volume will stimulate the thinking of active prospective memory researchers, provide a coherent organization of the area for the increasing number of people who are interested in prospective memory but who are not yet actively conducting research in the area, and serve as a book of readings for upper division seminars.




Critical Appraisal of Epidemiological Studies and Clinical Trials


Book Description

This book presents a logical system of critical appraisal, to allow readers to evaluate studies and to carry out their own studies more effectively. This system emphasizes the central importance of cause and effect relationships. Its great strength is that it is applicable to a wide range of issues, and both to intervention trials and observational studies. This system unifies the often different approaches used in epidemiology, health services research, clinical trials, and evidence-based medicine, starting from a logical consideration of cause and effect. The author's approach to the issues of study design, selection of subjects, bias, confounding, and the place of statistical methods has been praised for its clarity and interest. Systematic reviews, meta-analysis, and the applications of this logic to evidence-based medicine, knowledge-based health care, and health practice and policy are discussed. Current and often controversial examples are used, including screening for prostate cancer, publication bias in psychiatry, public health issues in developing countries, and conflicts between observational studies and randomized trials. Statistical issues are explained clearly without complex mathematics, and the most useful methods are summarized in the appendix. The final chapters give six applications of the critical appraisal of major studies: randomized trials of medical treatment and prevention, a prospective and a retrospective cohort study, a small matched case-control study, and a large case-control study. In these chapters, sections of the original papers are reproduced and the original studies placed in context by a summary of current developments.




Practical Biostatistics


Book Description

Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making. It is a practice that uses statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical research has produced a need for life scientists and clinical researchers to assimilate biostatistics into their work to meet efficacy and practical standards. Practical Biostatistics provides researchers, medical professionals, and students with a friendly, practical guide to biostatistics. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials. - Customized presentation for biological investigators with examples taken from current clinical trials in multiple disciplines - Clear and concise definitions and examples provide a pragmatic guide to bring clarity to the applications of statistics in improving human health - Addresses the challenge of assimilation of mathematical concepts to better interpret literature, to build stronger studies, to present research effectively, and to improve communication with supporting biostatisticians




A Guide to the Scientific Career


Book Description

A concise, easy-to-read source of essential tips and skills for writing research papers and career management In order to be truly successful in the biomedical professions, one must have excellent communication skills and networking abilities. Of equal importance is the possession of sufficient clinical knowledge, as well as a proficiency in conducting research and writing scientific papers. This unique and important book provides medical students and residents with the most commonly encountered topics in the academic and professional lifestyle, teaching them all of the practical nuances that are often only learned through experience. Written by a team of experienced professionals to help guide younger researchers, A Guide to the Scientific Career: Virtues, Communication, Research and Academic Writing features ten sections composed of seventy-four chapters that cover: qualities of research scientists; career satisfaction and its determinants; publishing in academic medicine; assessing a researcher’s scientific productivity and scholarly impact; manners in academics; communication skills; essence of collaborative research; dealing with manipulative people; writing and scientific misconduct: ethical and legal aspects; plagiarism; research regulations, proposals, grants, and practice; publication and resources; tips on writing every type of paper and report; and much more. An easy-to-read source of essential tips and skills for scientific research Emphasizes good communication skills, sound clinical judgment, knowledge of research methodology, and good writing skills Offers comprehensive guidelines that address every aspect of the medical student/resident academic and professional lifestyle Combines elements of a career-management guide and publication guide in one comprehensive reference source Includes selected personal stories by great researchers, fascinating writers, inspiring mentors, and extraordinary clinicians/scientists A Guide to the Scientific Career: Virtues, Communication, Research and Academic Writing is an excellent interdisciplinary text that will appeal to all medical students and scientists who seek to improve their writing and communication skills in order to make the most of their chosen career.




Global Business Leadership Development for the Fourth Industrial Revolution


Book Description

As the world has adapted to the age of digital technology, present day business leaders are required to change with the times as well. Addressing and formatting their business practices to not only encompass digital technologies, but expand their capabilities, the leaders of today must be flexible and willing to familiarize themselves with all types of global business practices. Global Business Leadership Development for the Fourth Industrial Revolution is a collection of advanced research on the methods and tactics utilized to succeed as a leader in the digital age. While highlighting topics including data privacy, corporate governance, and risk management, this book is ideally designed for business professionals, administrators, managers, executives, researchers, academicians, and business students who want to improve their understanding of the strategic role of digital technologies in the global economy, in networks and organizations, in teams and work groups, in information systems, and at the level of individuals as actors in digitally networked environments




From Optimal Tax Theory to Tax Policy


Book Description

An economist examines the evolution of optimal tax analysis and its influence on tax policy design. Many things inform a country's choice of tax system, including political considerations, public opinion, bureaucratic complexities, and ideas drawn from theoretical analysis. In this book, Robin Boadway examines the role of optimal tax analysis in informing and influencing tax policy design. Scholars of public economics formulate models of optimal tax-transfer systems based on normative principles that reflect efficiency and equity considerations. They use that analysis to form views about the optimal design or reform of actual tax systems that are much more complicated than their models. Boadway argues that there is an important symbiosis between ideas drawn from normative tax analysis and tax policies actually enacted. Ideas germinated by normative analyses have led to the widespread adoption of the value-added tax, the use of refundable tax credits, and various business tax reforms. Other ideas provide rationales for existing features of tax systems, including the tax treatment of retirement savings and human capital investment. Boadway charts the evolution of optimal tax analysis and discusses the lessons it holds for tax policy. He describes the theoretical challenges posed by recent findings in such fields as behavioral economics and social choice and considers how optimal tax analysis might adapt to these new paradigms. His analysis offers a timely assessment of the role that optimal tax theory has played in establishing the principles that continue to inform tax policy.