Issues in Risk Assessment


Book Description

The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.




Population-Level Ecological Risk Assessment


Book Description

Most ecological risk assessments consider the risk to individual organisms or organism-level attributes. From a management perspective, however, risks to population-level attributes and processes are often more relevant. Despite many published calls for population risk assessment and the abundance of available scientific research and technical tool




Ecological Risk Assessment


Book Description

Recently, environmental scientists have been required to perform a new type of assessment-ecological risk assessment. This is the first book that explains how to perform ecological risk assessments and gives assessors access to the full range of useful data, models, and conceptual approaches they need to perform an accurate assessment. It explains how ecological risk assessment relates to more familiar types of assessments. It also shows how to organize and conduct an ecological risk assessment, including defining the source, selecting endpoints, describing the relevant features of the receiving environment, estimating exposure, estimating effects, characterizing the risks, and interacting with the risk manager. Specific technical topics include finding and selecting toxicity data; statistical and mathematical models of effects on organisms, populations, and ecosystems; estimation of chemical fate parameters; modeling of chemical transport and fate; estimation of chemical uptake by organisms; and estimation, propagation, and presentation of uncertainty. Ecological Risk Assessment also covers conventional risk assessments, risk assessments for existing contamination, large scale problems, exotic organisms, and risk assessments based on environmental monitoring. Environmental assessors at regulatory agencies, consulting firms, industry, and government labs need this book for its approaches and methods for ecological risk assessment. Professors in ecology and other environmental sciences will find the book's practical preparation useful for classroom instruction. Environmental toxicologists and chemists will appreciate the discussion of the utility for risk assessment of particular toxicity tests and chemical determinations.




Gene Drives on the Horizon


Book Description

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.




Environmental Risk Assessment


Book Description

The purpose of risk assessment is to support science-based decisions about how to solve complex societal problems. Indeed, the problems humankind faces in the 21st century have many social, political, and technical complexities. Environmental risk assessment in particular is of increasing importance as health and safety regulations grow and become more complicated. Environmental Risk Assessment: A Toxicological Approach, 2nd Edition looks at various factors relating to exposure and toxicity, human health, and risk. In addition to the original chapters being updated and expanded upon, four new chapters discuss current software and platforms that have recently been developed and provide examples of risk characterizations and scenarios. Features: Introduces the science of risk assessment—past, present, and future Provides environmental sampling data for conducting practice risk assessments Considers how bias and conflict of interest affect science-based decisions in the 21st century Includes fully worked examples, case studies, discussion questions, and suggestions for additional reading Discusses new software and computational platforms that have developed since the first edition Aimed at the next generation of risk assessors and students who need to know more about developing, conducting, and interpreting risk assessments, the book delivers a comprehensive view of the field, complete with sufficient background to enable readers to probe for themselves the science underlying the key issues in environmental risk.




Introduction to Risk Analysis


Book Description

Written for safety and loss-control, environmental, and quality managers, this is the first comprehensive, integrated guide to developing a complete environmental risk analysis for regulated substances and processes. Unlike other books, Introduction to Risk Analysis looks at risk from a regulatory perspective, allowing both professionals in regulatory agencies concerned with risk_including OSHA, EPA, USDA, DOT, FDA, and state environmental agencies_and professionals in any agency-regulated industry to understand and implement the methods required for proper risk assessment. The authors examine risk and the structure of analysis. Emphasizing the predictive nature of risk, they discuss the quantitative nature of risk and explore quantitative-analysis topics, including data graphing, logarithmic thinking, risk estimating, and curve fitting. Chapters include discussions on functions, models, and uncertainties; the regulatory process; risk assessment; exposure; dosimetry; epidemiology; toxicology; risk characterization; comparative risk assessment; ecological risk assessment; risk management; and risk communication. Six in-depth case studies, an annotated bibliography, and more than 50 figures are also included.




Science and Decisions


Book Description

Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.







Risk Assessment and Management Handbook for Environmental, Health, and Safety Professionals


Book Description

A conmprehensive reference that blends theory with case studies from both the US and abroad to provide practical guidance on a variety of risk assessment and management strategies, which may be tailored to any particular company. The volume contains 18 chapters grouped into seven parts: overview and linkages (3 chapters); health (4 chapters); safety (2 chapters); ecology (3 chapters); international risk assessment (2 chapters); risk communication (2 chapters); and additional perspectives (2 chapters: industrial ecology and comprehensive risk assessment; and risk-based decision making--integrating risk management into business planning). Annotation copyright by Book News, Inc., Portland, OR




Ecological Risk Assessment Issue Papers


Book Description

Provides scientific & technical information that scientists can use along with other materials to develop ecological risk assessment guidance. Highlights important principles & approaches relevant to the ecological risk assessment framework that scientists should consider in preparing guidelines. Covers: biological stressors, ecological recovery, exposures characteristics, & much more. Figures & tables.