Regulators and Effectors of Small GTPases: Ras Family


Book Description

The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras. - Includes a database for Ras family proteins and their effectors and regulators - Complimentary to volume 406 coverage of the Rho family - Over 150 international contributors




Hunter and Warrior of Rhudaur


Book Description

Riam, a hunter in his hillman clan, has no idea what is about to happen to him. As he returns from a hunt for food, he encounters trolls, orcs, and a rogue hillman ranger who plots against his people. With the help of the dwarf Toram, whom he saves, Riam avenges his betrayed clan and discovers how the manipulations of clan politics is normal for his people and decides to try a new way. With the help of Toram, he uses the wealth and weapons he acquires along the way to leave the culture of the hillmen and become a dwarf-trained warrior in pursuit of vengeance for his dead father and mother. He joins a quest that seeks to fulfill the ambitions of all the members of an adventuring party, and along with Toram, his dwarven friend, he heads north into perilous danger. Trespassing into the lands of the Witch King and entering into an orcish stronghold to acquire a fabled lost treasure almost costs them their lives. Riam encounters a dragon guarding a treasure, and his method of dealing with it leaves more problems than answers. The group finishes their quest in the north but are left with the problem of returning south. The return trip is as dangerous but just as profitable as they leave the north and return home.







Lies of Descent


Book Description

"The Fallen Gods War drove the remnants of a victorious army across the ocean in search of a new homeland. A thousand years later, the lifeless continent of Draegora is largely forgotten, a symbol for the regiments that remain. Demons to some. Protectors to others. The power of their god-touched blades has forged a nation, though many resent their absolute control. Riam and Nola are unknowing descendants of the old world. When it's discovered they carry enough Draegoran blood to serve in the regiments, they are dragged away from their families to begin training. If they survive, they will be expected to enforce the laws of the covenant, to fight the Esharii tribesmen who raid along the border, and to be judge, jury, and executioners for those accused of crimes. For Riam, who welcomes his escape from an abusive father, the power to protect those who cannot defend themselves is alluring. For Nola, who wishes to return home, it is a betrayal by all she holds dear. Neither is given a choice...and neither may ever get the chance to serve."--Provided by publisher.




Poisonous Amour


Book Description

War has bled onto the streets worldwide with only one group standing between The Order and all mankind. Their newest recruit must now decide between loyalty and love. In the darkest corners of Van City, a deadly war rages between the darkness and the irregulars. With humanity on their knees, there is one group standing between them and their complete destruction—the Slayers. And now, their newest recruit, Bane, a Therian, must choose between his duty and his love. Viciously loyal, ruthless and deadly, Bane has given everything to become a member of the Slayers. But when fate intervenes, he discovers his loyalty rests elsewhere. Trapped between his love for Jessamine and the fate of mankind, Bane must decide between the lives of his fellow Slayers and that of the woman he loves—Jessamine, a Hunter and sister to the Calyph of The Rancor Order. Will true love win out—or will fate throw him another curveball and take his life?




The Genesys Project


Book Description

FROM POPULAR ROMANCE AUTHOR L.A. KENNEDY The Genesys Project &– the complete box set 1 - Immortal Amour Leading a fierce battle to protect his race, Cael must choose between the life he has and the woman he wants. 2 - Dark Amour There's war brewing and only one group of Slayers to protect their race. Their second-in-command must choose between the life he'd be forced to live and the life he'd kill for. 3 - Wicked Amour One group of Slayers stands between the Rancor Order and the irregulars. Their most trusted Slayer must decide between releasing his wicked darkness or losing the woman he loves. 4 - Poisonous Amour War has bled onto the streets worldwide with only one group standing between The Order and all mankind. Their newest recruit must now decide between loyalty and love. Hunted by an evil dark as night, the irregulars have one hope for survival, The Genesys Project. A band of irregulars who defend their society against The Rancor Order and Proletaryans, a soulless breed of once humans who are controlled by the son of The Genesys, Strain. They are known as Slayers. They are assassins with immunity. They are the Slayers for their race. Their only mission was to take out each and every member of The Rancor Order, focusing on the complete annihilation of the Genesys.




Wicked Amour


Book Description

One group of Slayers stands between the Rancor Order and the irregulars. Their most trusted Slayer must decide between releasing his wicked darkness or losing the woman he loves. When the tides shift in the war against the Rancor Order, the Slayers are put to the test as the first Strain emerges. Bellum—the bringer of war—returns to Van City, hunting for the Slayers. She wants a piece of the pie. The most trusted of the Slayers, Riam—of unknown origin—is faced with an adversary so great it is all-consuming. Riam, who has perfect control of every emotion he possesses, is overcome by one he doesn't feel he's worthy of—love. His formidable opponent? A woman held captive by the Genesys, Sasha Grant. Sasha isn't like any other woman he's met before. She is like him to the wicked core. In order to save her life, he must call on his people. Reaching out to those he'd shut the door on hundreds of years ago sends Riam into a head-on collision with the world that opened the door for The Genesys. Breaking all the rules, Riam lets out the wicked warrior locked deep within his soul and hunts for the woman he'd die for. The war has only just begun.




The Marriage of Figaro


Book Description

Mozart's beloved comic romp, reprinted from a late (C. F. Peters, 1941) edition, which preserves Mozart's autograph manuscript and early translations of the libretto and includes passages that are often cut in other editions.




Cell-Matrix Junctions—Advances in Research and Application: 2013 Edition


Book Description

Cell-Matrix Junctions—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about ZZZAdditional Research. The editors have built Cell-Matrix Junctions—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cell-Matrix Junctions—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.