Integrated Cost-Schedule Risk Analysis


Book Description

Project managers tend to believe their cost estimates - whether they have exceeded budgets in the past or not. It is dangerous to accept the engineering cost estimates, which are often optimistic or unrealistic. Though cost estimates incorporate contingency reserves below-the-line, these estimates of reserves often do not benefit from a rigorous assessment of risk to project costs. Risks to cost come from multiple sources including uncertain project duration, which is often ignored in cost risk analyses. In short, experience shows that cost estimating on projects is rarely successful - cost overruns routinely occur. There are effective ways to estimate the impact on the cost of complex projects from project risks of all types, including traditional cost-type risks and the indirect but often substantial impact from risks usually thought of as affecting project schedules. Integrated cost-schedule risk anlaysis helps us determine how likely the project will go over budget with the current plan, how much contingency reserve is required to achieve a desired level of certainty, and which risks are most important so the project manager can mitigate them and achieve a better result. Integrated Cost-Schedule Risk Analysis provides solutions for these and other challenges. This book follows on from David Hulett's highly-praised Practical Schedule Risk Analysis. It focuses on the way that schedule risk can generate cost risk, and how to handle this relationship. It also applies the Risk Driver Method to the analysis so that you can clearly and transparently identify the key risks, rather than just the most risky cost line items. With detailed worked examples and over 70 illustrations, Integrated Cost-Schedule Risk Analysis offers the definitive guide to this critically important aspect of project management from surely the world's leading commentator.




Principles and Methods of Toxicology, Fifth Edition


Book Description

Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.




Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment


Book Description

Quantitative structure-activity relationships (QSARs) represent predictive models derived from the application of statistical tools correlating biological activity or other properties of chemicals with descriptors representative of molecular structure and/or property. Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment discusses recent advancements in the field of QSARs with special reference to their application in drug development, predictive toxicology, and chemical risk analysis. Focusing on emerging research in the field, this book is an ideal reference source for industry professionals, students, and academicians in the fields of medicinal chemistry and toxicology.







Advances in Computer and Information Sciences and Engineering


Book Description

Advances in Computer and Information Sciences and Engineering includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of Computer Science, Software Engineering, Computer Engineering, and Systems Engineering and Sciences. Advances in Computer and Information Sciences and Engineering includes selected papers from the conference proceedings of the International Conference on Systems, Computing Sciences and Software Engineering (SCSS 2007) which was part of the International Joint Conferences on Computer, Information and Systems Sciences and Engineering (CISSE 2007).




Encyclopedia of Quantitative Risk Analysis and Assessment


Book Description

Leading the way in this field, the Encyclopedia of Quantitative Risk Analysis and Assessment is the first publication to offer a modern, comprehensive and in-depth resource to the huge variety of disciplines involved. A truly international work, its coverage ranges across risk issues pertinent to life scientists, engineers, policy makers, healthcare professionals, the finance industry, the military and practising statisticians. Drawing on the expertise of world-renowned authors and editors in this field this title provides up-to-date material on drug safety, investment theory, public policy applications, transportation safety, public perception of risk, epidemiological risk, national defence and security, critical infrastructure, and program management. This major publication is easily accessible for all those involved in the field of risk assessment and analysis. For ease-of-use it is available in print and online.




Identifying and Managing Project Risk


Book Description

Winner of the Project Management Institute’s David I. Cleland Project Management Literature Award 2010 It’s no wonder that project managers spend so much time focusing their attention on risk identification. Important projects tend to be time constrained, pose huge technical challenges, and suffer from a lack of adequate resources. Identifying and Managing Project Risk, now updated and consistent with the very latest Project Management Body of Knowledge (PMBOK)® Guide, takes readers through every phase of a project, showing them how to consider the possible risks involved at every point in the process. Drawing on real-world situations and hundreds of examples, the book outlines proven methods, demonstrating key ideas for project risk planning and showing how to use high-level risk assessment tools. Analyzing aspects such as available resources, project scope, and scheduling, this new edition also explores the growing area of Enterprise Risk Management. Comprehensive and completely up-to-date, this book helps readers determine risk factors thoroughly and decisively...before a project gets derailed.




Domino Effects in the Process Industries


Book Description

Domino Effects in the Process Industries discusses state-of-the-art theories, conceptual models, insights and practical issues surrounding large-scale knock-on accidents—so-called domino effects—in the chemical and process industries. The book treats such extremely low-frequency phenomena from a technological perspective, studying possible causes and introducing several approaches to assess and control the risks of these scenarios. The authors also examine these events from a managerial viewpoint, discussing single and multi-plant management insights and requirements to take pro-active measures to prevent such events. Academics, regulators, and industrialists who study and analyze domino effects in order to prevent such events will find the book unique and highly valuable. - Outlines available methods in analyzing these events, aiding understanding of the accidents and their causes - Covers current modelling, control and management tactics of domino effects, -facilitating prevention - Identifies areas where new research is needed




Geotechnical Safety and Risk V


Book Description

Geotechnical Risk and Safety V contains contributions presented at the 5th International Symposium on Geotechnical Safety and Risk (5th ISGSR, Rotterdam, 13-16 October 2015) which was organized under the auspices of the Geotechnical Safety Network (GEOSNet) and the following technical committees of the of the International Society of Soil Mechanics and Geotechnical Engineering (ISSGME): • TC304 Engineering Practice of Risk Assessment & Management • TC205 Safety and Serviceability in Geotechnical Design • TC212 Deep Foundations • TC302 Forensic Geotechnical Engineering Geotechnical Risk and Safety V covers seven themes: 1. Geotechnical Risk Management and Risk Communication 2. Variability in Ground Conditions and Site Investigation 3. Reliability and Risk Analysis of Geotechnical Structures 4. Limit-state design in Geotechnical Engineering 5. Assessment and Management of Natural Hazards 6. Contractual and Legal Issues of Foundation and (Under)Ground Works 7. Case Studies, Monitoring and Observational Method The 5th ISGSR is the continuation of a series of symposiums and workshops on geotechnical risk and reliability, starting with LSD2000 (Melbourne, Australia), IWS2002 (Tokyo and Kamakura, Japan), LSD2003 (Cambridge, USA), Georisk2004 (Bangalore, India), Taipei2006 (Taipei, Taiwan), the 1st ISGSR (Shanghai, China, 2007), the 2nd ISGSR (Gifu, Japan, 2009), the 3rd ISGSR (Munich, Germany, 2011) and the 4th ISGSR (Hong Kong, 2013).




Encyclopedia of Environmental Health


Book Description

Encyclopedia of Environmental Health, Second Edition, Six Volume Set presents the newest release in this fundamental reference that updates and broadens the umbrella of environmental health, especially social and environmental health for its readers. There is ongoing revolution in governance, policies and intervention strategies aimed at evolving changes in health disparities, disease burden, trans-boundary transport and health hazards. This new edition reflects these realities, mapping new directions in the field that include how to minimize threats and develop new scientific paradigms that address emerging local, national and global environmental concerns. Represents a one-stop resource for scientifically reliable information on environmental health Fills a critical gap, with information on one of the most rapidly growing scientific fields of our time Provides comparative approaches to environmental health practice and research in different countries and regions of the world Covers issues behind specific questions and describes the best available scientific methods for environmental risk assessment