Complex Systems Science in Biomedicine


Book Description

Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.




Introduction to Urban Science


Book Description

A novel, integrative approach to cities as complex adaptive systems, applicable to issues ranging from innovation to economic prosperity to settlement patterns. Human beings around the world increasingly live in urban environments. In Introduction to Urban Science, Luis Bettencourt takes a novel, integrative approach to understanding cities as complex adaptive systems, claiming that they require us to frame the field of urban science in a way that goes beyond existing theory in such traditional disciplines as sociology, geography, and economics. He explores the processes facilitated by and, in many cases, unleashed for the first time by urban life through the lenses of social heterogeneity, complex networks, scaling, circular causality, and information. Though the idea that cities are complex adaptive systems has become mainstream, until now those who study cities have lacked a comprehensive theoretical framework for understanding cities and urbanization, for generating useful and falsifiable predictions, and for constructing a solid body of empirical evidence so that the discipline of urban science can continue to develop. Bettencourt applies his framework to such issues as innovation and development across scales, human reasoning and strategic decision-making, patterns of settlement and mobility and their influence on socioeconomic life and resource use, inequality and inequity, biodiversity, and the challenges of sustainable development in both high- and low-income nations. It is crucial, says Bettencourt, to realize that cities are not "zero-sum games" and that knowledge, human cooperation, and collective action can build a better future.




The Madame Curie Complex


Book Description

The historian and author of Lillian Gilbreth examines the “Great Man” myth of science with profiles of women scientists from Marie Curie to Jane Goodall. Why is science still considered to be predominantly male profession? In The Madame Curie Complex, Julie Des Jardin dismantles the myth of the lone male genius, reframing the history of science with revelations about women’s substantial contributions to the field. She explores the lives of some of the most famous female scientists, including Jane Goodall, the eminent primatologist; Rosalind Franklin, the chemist whose work anticipated the discovery of DNA’s structure; Rosalyn Yalow, the Nobel Prize-winning physicist; and, of course, Marie Curie, the Nobel Prize-winning pioneer whose towering, mythical status has both empowered and stigmatized future generations of women considering a life in science. With lively anecdotes and vivid detail, The Madame Curie Complex reveals how women scientists have changed the course of science—and the role of the scientist—throughout the twentieth century. They often asked different questions, used different methods, and came up with different, groundbreaking explanations for phenomena in the natural world.




Principles of Systems Science


Book Description

This pioneering text provides a comprehensive introduction to systems structure, function, and modeling as applied in all fields of science and engineering. Systems understanding is increasingly recognized as a key to a more holistic education and greater problem solving skills, and is also reflected in the trend toward interdisciplinary approaches to research on complex phenomena. While the concepts and components of systems science will continue to be distributed throughout the various disciplines, undergraduate degree programs in systems science are also being developed, including at the authors’ own institutions. However, the subject is approached, systems science as a basis for understanding the components and drivers of phenomena at all scales should be viewed with the same importance as a traditional liberal arts education. Principles of Systems Science contains many graphs, illustrations, side bars, examples, and problems to enhance understanding. From basic principles of organization, complexity, abstract representations, and behavior (dynamics) to deeper aspects such as the relations between information, knowledge, computation, and system control, to higher order aspects such as auto-organization, emergence and evolution, the book provides an integrated perspective on the comprehensive nature of systems. It ends with practical aspects such as systems analysis, computer modeling, and systems engineering that demonstrate how the knowledge of systems can be used to solve problems in the real world. Each chapter is broken into parts beginning with qualitative descriptions that stand alone for students who have taken intermediate algebra. The second part presents quantitative descriptions that are based on pre-calculus and advanced algebra, providing a more formal treatment for students who have the necessary mathematical background. Numerous examples of systems from every realm of life, including the physical and biological sciences, humanities, social sciences, engineering, pre-med and pre-law, are based on the fundamental systems concepts of boundaries, components as subsystems, processes as flows of materials, energy, and messages, work accomplished, functions performed, hierarchical structures, and more. Understanding these basics enables further understanding both of how systems endure and how they may become increasingly complex and exhibit new properties or characteristics. Serves as a textbook for teaching systems fundamentals in any discipline or for use in an introductory course in systems science degree programs Addresses a wide range of audiences with different levels of mathematical sophistication Includes open-ended questions in special boxes intended to stimulate integrated thinking and class discussion Describes numerous examples of systems in science and society Captures the trend towards interdisciplinary research and problem solving




Applying Cognitive Science to Education


Book Description

An accessible introduction to some of the cognitive issues important for thinking and learning in scientific or other complex domains (such as mathematics, physics, chemistry, engineering, or expository writing), with practical educational applications and implementation methods. Many students find it difficult to learn the kind of knowledge and thinking required by college or high school courses in mathematics, science, or other complex domains. Thus they often emerge with significant misconceptions, fragmented knowledge, and inadequate problem-solving skills. Most instructors or textbook authors approach their teaching efforts with a good knowledge of their field of expertise but little awareness of the underlying thought processes and kinds of knowledge required for learning in scientific domains. In this book, Frederick Reif presents an accessible coherent introduction to some of the cognitive issues important for thinking and learning in scientific or other complex domains (such as mathematics, science, physics, chemistry, biology, engineering, or expository writing). Reif, whose experience teaching physics at the University of California led him to explore the relevance of cognitive science to education, examines with some care the kinds of knowledge and thought processes needed for good performance; discusses the difficulties faced by students trying to deal with unfamiliar scientific domains; describes some explicit teaching methods that can help students learn the requisite knowledge and thinking skills; and indicates how such methods can be implemented by instructors or textbook authors. Writing from a practically applied rather than predominantly theoretical perspective, Reif shows how findings from recent research in cognitive science can be applied to education. He discusses cognitive issues related to the kind of knowledge and thinking skills that are needed for science or mathematics courses in high school or colleges and that are essential prerequisites for more advanced intellectual performance. In particular, he argues that a better understanding of the underlying cognitive mechanisms should help to achieve a more scientific approach to science education.




How Behavior Spreads


Book Description

A new, counterintuitive theory for how social networks influence the spread of behavior New social movements, technologies, and public-health initiatives often struggle to take off, yet many diseases disperse rapidly without issue. Can the lessons learned from the viral diffusion of diseases improve the spread of beneficial behaviors and innovations? How Behavior Spreads presents over a decade of original research examining how changes in societal behavior—in voting, health, technology, and finance—occur and the ways social networks can be used to influence how they propagate. Damon Centola's startling findings show that the same conditions that accelerate the viral expansion of an epidemic unexpectedly inhibit the spread of behaviors. How Behavior Spreads is a must-read for anyone interested in how the theory of social networks can transform our world.




The Science of Expertise


Book Description

Offering the broadest review of psychological perspectives on human expertise to date, this volume covers behavioral, computational, neural, and genetic approaches to understanding complex skill. The chapters show how performance in music, the arts, sports, games, medicine, and other domains reflects basic traits such as personality and intelligence, as well as knowledge and skills acquired through training. In doing so, this book moves the field of expertise beyond the duality of "nature vs. nurture" toward an integrative understanding of complex skill. This book is an invaluable resource for researchers and students interested in expertise, and for professionals seeking current reviews of psychological research on expertise.




Model-oriented Systems Engineering Science


Book Description

Systems engineering (SE) is experiencing a significant expansion that encompasses increasingly complex systems. However, a common body of knowledge on how to apply complex systems engineering (CSE) has yet to be developed. A combination of people and other autonomous agents, crossing organization boundaries and continually changing, these hybrid sy




Big Science


Book Description

A heroic time -- South Dakota boy -- "I'm going to be famous" -- Shims and sealing wax -- Oppie -- The deuton affair -- The cyclotron republic -- John Lawrence's mice -- Laureate -- Mr. Loomis -- "Ernest, are you ready?" -- The racetrack -- Oak Ridge -- The road to Trinity -- The postwar bonanza -- Oaths and loyalties -- The shadow of the Super -- Livermore -- The Oppenheimer affair -- The return of small science -- The "clean bomb" -- Element 103.




Data Science and Complex Networks


Book Description

This book provides a comprehensive yet short description of the basic concepts of Complex Network theory. In contrast to other books the authors present these concepts through real case studies. The application topics span from Foodwebs, to the Internet, the World Wide Web and the Social Networks, passing through the International Trade Web and Financial time series. The final part is devoted to definition and implementation of the most important network models. The text provides information on the structure of the data and on the quality of available datasets. Furthermore it provides a series of codes to allow immediate implementation of what is theoretically described in the book. Readers already used to the concepts introduced in this book can learn the art of coding in Python by using the online material. To this purpose the authors have set up a dedicated web site where readers can download and test the codes. The whole project is aimed as a learning tool for scientists and practitioners, enabling them to begin working instantly in the field of Complex Networks.