Semblance Hypothesis of Memory


Book Description

The semblance hypothesis explains how associative memory can result from the multidimensional semblance of activity from a specific set of presynaptic terminals at different orders of neurons. The hypothesized basic units are then examined for their feasibility to explain various physiological and pathological conditions of the nervous system, ranging from physiological time-scales of memory retrieval to plausible explanation for long term potentiation (LTP).




Semblance of Activity at the Shared Postsynapses and Extracellular Matrices


Book Description

Semblance Hypothesis is a structure-function hypothesis that explains a possible way of brain function. Based on a definition of memory, the author hypothesize certain structural patterns of the dendritic spines, shows evidence for these structures from the literature and use inductive reasoning for their role in explaining memory and other brain functions.




Electroconvulsive and Neuromodulation Therapies


Book Description

Electroconvulsive therapy (ECT) is a psychiatric treatment involving the induction of a seizure through the transmission of electricity in the brain. Because of exploitation movies and greatly heightened drug company promotional activities ECT was used less frequently in the 1980s and 1990s. Eventually these movies were understood as unrealistic. Now these drugs are increasingly recognized as dangers to body health. Because of recent refinements and a far better scientific understanding of the clinical procedures and mechanisms underpinning ECT, this treatment modality has seen a resurgence in use and widespread appreciation of its safety. This book is the new definitive reference on electroconvulsive and neuromodulation therapies. It comprehensively covers the scientific basis and clinical practice of ECT as well as comparisons between ECT and medication therapies including the new generation of antipsychotic drugs. It also provides readers with administrative perspectives and specific details for the management of this modality in clinical practice. The new forms of nonconvulsive electrical and magnetic brain stimulation therapy are also covered in detail, in a separate section. The chapter authors are leading scholars and clinicians.







Signaling and the Cytoskeleton


Book Description

This monograph explores the relationships between cell signaling and the cytoplasmic cytoskeleton in fundamental cell processes, thus bridging the gap between two very active aspects of molecular cell biology. It covers the two main - and reciprocal - questions of these relationships: How are structure and function of the cytoskeleton affected by external signals which impinge on the cell? How does the cytoskeleton influence the cellular signaling processes which determine cell behavior?




Networks of the Brain


Book Description

An integrative overview of network approaches to neuroscience explores the origins of brain complexity and the link between brain structure and function. Over the last decade, the study of complex networks has expanded across diverse scientific fields. Increasingly, science is concerned with the structure, behavior, and evolution of complex systems ranging from cells to ecosystems. In Networks of the Brain, Olaf Sporns describes how the integrative nature of brain function can be illuminated from a complex network perspective. Highlighting the many emerging points of contact between neuroscience and network science, the book serves to introduce network theory to neuroscientists and neuroscience to those working on theoretical network models. Sporns emphasizes how networks connect levels of organization in the brain and how they link structure to function, offering an informal and nonmathematical treatment of the subject. Networks of the Brain provides a synthesis of the sciences of complex networks and the brain that will be an essential foundation for future research.




Color Atlas of Pharmacology


Book Description




Neuronal Network Analysis


Book Description

In the last few years, technologies that allow for monitoring and manipulating neuronal networks at a single cell resolution have been rapidly expanding. In Neuronal Network Analysis: Concepts and Experimental Approaches, experts in the field provide an overview of some of the most advanced techniques for the study of neuronal circuits, highlighting current technical limitations and providing a vision of what is yet to come. Broken into six convenient, interdependent section, this volume covers optical approaches, electrophysiological approaches, both in vitro and in vivo, optogenetics, morpho-functional approaches, and neuronal network analysis in humans. As a volume in the Neuromethods series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Neuronal Network Analysis: Concepts and Experimental Approaches will be useful for early career neuroscientists, as well as for experienced neuroscientists, by providing a practical framework for studying the brain as an organ while maintaining an appreciation for its cellular diversity.




Artificial Sight


Book Description

This book describes advances in implantable neural stimulation technology to restore partial sight to people who are blind from retinal degnerative diseases such as age-related macular degeneration and retintis pigmentosa. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The book summarizes the state of research and clinical practice in the field and reviews the current ideas and approaches of its leading researchers and practitioners.




Towards a Theory of Thinking


Book Description

What is Thinking? – Trying to Define an Equally Fascinating and Elusive Phenomenon Human thinking is probably the most complex phenomenon that evolution has come up with until now. There exists a broad spectrum of definitions, from subs- ing almost all processes of cognition to limiting it to language-based, sometimes even only to formalizable reasoning processes. We work with a “medium sized” definition according to which thinking encompasses all operations by which cog- tive agents link mental content in order to gain new insights or perspectives. Mental content is, thus, a prerequisite for and the substrate on which thinking operations are executed. The largely unconscious acts of perceptual object stabilization, ca- gorization, emotional evaluation – and retrieving all the above from memory inscriptions – are the processes by which mental content is generated, and are, therefore, seen as prerequisites for thinking operations. In terms of a differentia specifica, the notion of “thinking” is seen as narrower than the notion of “cognition” and as wider than the notion of “reasoning”. Thinking is, thus, seen as a subset of cognition processes; and reasoning processes are seen as a subset of thinking. Besides reasoning, the notion of thinking includes also nonexplicit, intuitive, and associative processes of linking mental content. According to this definition, thinking is not dependant on language, i. e. also many animals and certainly all mammals show early forms of thinking.