Webvision
Author : Helga Kolb
Publisher :
Page : pages
File Size : 35,51 MB
Release : 2007
Category :
ISBN :
Author : Helga Kolb
Publisher :
Page : pages
File Size : 35,51 MB
Release : 2007
Category :
ISBN :
Author : Kirill A. Martemyanov
Publisher : Springer
Page : 197 pages
File Size : 15,6 MB
Release : 2014-09-04
Category : Medical
ISBN : 1493912186
The main purpose of this volume is to provide a focused analysis of the function of the G protein-coupled signaling pathways that operate in the interconnected network of retinal neurons as they detect and encode the information carried by light. The organization of this volume will generally follow the path of signal flow in the retina. First we will describe recent advances in understanding the phototransduction cascade of rod and cone photoreceptors, which use signaling cascade based on the GPCR rhodopsin to transduce incident light into neural activity. Chapters will be devoted to unique specializations of the two major types of photosensitive cells that comprise the predominant input for our spatial and color vision. Subsequently, the mechanisms of synaptic information encoding by retinal ON bipolar cells will be described, where the GPCR mGluR6 plays a fundamental role. Chapters in this section will examine macromolecular organization of the mGluR6 signaling pathway as well as current understanding of its function. The functional characteristics of this signaling mechanism will be explored in detail. Additionally, this section will cover the role of dopamine receptors in modulating signal transmission between photoreceptors and ON-bipolar cells. Finally, chapters will be focused on the output neurons of the inner retina, ganglion cells, where the components of the emerging GPCR melanopsin cascade in intrinsically photosensitive ganglion cells will be detailed. Collectively these mechanisms allow the retina to represent visual space over a wide range of light intensities.
Author : Steven J. Fliesler
Publisher : CRC Press
Page : 410 pages
File Size : 44,57 MB
Release : 2007-12-26
Category : Medical
ISBN : 1420007165
In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approache
Author : Takahisa Furukawa
Publisher : Springer
Page : 0 pages
File Size : 17,44 MB
Release : 2016-08-23
Category : Medical
ISBN : 9784431563358
This book provides a series of comprehensive views on various important aspects of vertebrate photoreceptors. The vertebrate retina is a tissue that provides unique experimental advantages to neuroscientists. Photoreceptor neurons are abundant in this tissue and they are readily identifiable and easily isolated. These features make them an outstanding model for studying neuronal mechanisms of signal transduction, adaptation, synaptic transmission, development, differentiation, diseases and regeneration. Thanks to recent advances in genetic analysis, it also is possible to link biochemical and physiological investigations to understand the molecular mechanisms of vertebrate photoreceptors within a functioning retina in a living animal. Photoreceptors are the most deeply studied sensory receptor cells, but readers will find that many important questions remain. We still do not know how photoreceptors, visual pigments and their signaling pathways evolved, how they were generated and how they are maintained. This book will make clear what is known and what is not known. The chapters are selected from fields of studies that have contributed to a broad understanding of the birth, development, structure, function and death of photoreceptor neurons. The underlying common word in all of the chapters that is used to describe these mechanisms is “molecule”. Only with this word can we understand how these highly specific neurons function and survive. It is challenging for even the foremost researchers to cover all aspects of the subject. Understanding photoreceptors from several different points of view that share a molecular perspective will provide readers with a useful interdisciplinary perspective.
Author : S. Archer
Publisher : Springer Science & Business Media
Page : 674 pages
File Size : 47,22 MB
Release : 2013-04-17
Category : Medical
ISBN : 9401706190
John Lythgoe was one of the pioneers of the 'Ecology of Vision', a subject that he ably delineated in his classic and inspirational book published some 20 years ago [1]. At heart, the original book aimed generally to identify inter-relationships between vision, animal behaviour and the environment. John Lythgoe excelled at identifying the interesting 'questions' in the ecology of an animal that fitted the 'answers' presented by an analysis of the visual system. Over the last twenty years, however, since Lythgoe's landmark publication, much progress has been made and the field has broadened considerably. In particular, our understanding of the 'adaptive mechanisms' underlying the ecology of vision has reached considerable depths, extending to the molecular dimension, partly as a result of development and application of new techniques. This complements the advances made in parallel in clinically oriented vision research [2]. The current book endeavours to review the progress made in the ecology of vision field by bringing together many of the major researchers presently active in the expanded subject area. The contents deal with theoretical and physical considerations of light and photoreception, present examples of visual system structure and function, and delve into aspects of visual behaviour and communi cation. Throughout the book, we have tried to emphasise one of the major themes to emerge within the ecology of vision: the high degree of adaptability that visual mechanisms are capable of undergoing in response to diverse, and dynamic, environments and behaviours.
Author : John E. Dowling
Publisher : Harvard University Press
Page : 310 pages
File Size : 38,21 MB
Release : 1987
Category : Medical
ISBN : 9780674766808
Author :
Publisher :
Page : 0 pages
File Size : 24,84 MB
Release : 2002
Category : Cells
ISBN : 9780815332183
Author : Hubert Vaudry
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 50,28 MB
Release : 2003
Category : Medical
ISBN : 9781402073069
Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.
Author : Misha Mahowald
Publisher : Springer Science & Business Media
Page : 227 pages
File Size : 34,33 MB
Release : 2012-12-06
Category : Technology & Engineering
ISBN : 1461527244
An Analog VLSI System for Stereoscopic Vision investigates the interaction of the physical medium and the computation in both biological and analog VLSI systems by synthesizing a functional neuromorphic system in silicon. In both the synthesis and analysis of the system, a point of view from within the system is adopted rather than that of an omniscient designer drawing a blueprint. This perspective projects the design and the designer into a living landscape. The motivation for a machine-centered perspective is explained in the first chapter. The second chapter describes the evolution of the silicon retina. The retina accurately encodes visual information over orders of magnitude of ambient illumination, using mismatched components that are calibrated as part of the encoding process. The visual abstraction created by the retina is suitable for transmission through a limited bandwidth channel. The third chapter introduces a general method for interchip communication, the address-event representation, which is used for transmission of retinal data. The address-event representation takes advantage of the speed of CMOS relative to biological neurons to preserve the information of biological action potentials using digital circuitry in place of axons. The fourth chapter describes a collective circuit that computes stereodisparity. In this circuit, the processing that corrects for imperfections in the hardware compensates for inherent ambiguity in the environment. The fifth chapter demonstrates a primitive working stereovision system. An Analog VLSI System for Stereoscopic Vision contributes to both computer engineering and neuroscience at a concrete level. Through the construction of a working analog of biological vision subsystems, new circuits for building brain-style analog computers have been developed. Specific neuropysiological and psychophysical results in terms of underlying electronic mechanisms are explained. These examples demonstrate the utility of using biological principles for building brain-style computers and the significance of building brain-style computers for understanding the nervous system.
Author : Kevin Moses
Publisher : Springer Science & Business Media
Page : 296 pages
File Size : 11,7 MB
Release : 2002-03-12
Category : Medical
ISBN : 9783540425908
1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.