Author : Victor R. Preedy
Publisher : Cambridge University Press
Page : 762 pages
File Size : 33,26 MB
Release : 2002-01-04
Category : Medical
ISBN : 9781841100296
Metabolic and functional impairments in skeletal muscle occur frequently, often in diverse conditions and each with different aetiologies, methods of diagnosis and treatment. This comprehensive text brings the complex facets of skeletal muscle pathology, diagnosis and management together.
Author : Ronald J. Korthuis
Publisher : Morgan & Claypool Publishers
Page : 147 pages
File Size : 37,49 MB
Release : 2011
Category : Medical
ISBN : 1615041834
The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References
Author : Andreas Rummel
Publisher : Springer
Page : 0 pages
File Size : 10,48 MB
Release : 2015-01-29
Category : Medical
ISBN : 9783642448898
The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.
Author : Institute of Medicine
Publisher : National Academies Press
Page : 448 pages
File Size : 29,2 MB
Release : 1999-09-15
Category : Technology & Engineering
ISBN : 0309172810
It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.
Author : Stirling Carpenter
Publisher : New York : Churchill Livingstone
Page : 812 pages
File Size : 11,4 MB
Release : 1984
Category : Medical
ISBN :
This book has been described as the bible of muscle disease, from both a scientific and a clinical point of view. It is a comprehensive work that explains and illustrates in detail all pathological reactions of skeletal muscles that occur in human disease. The microscopic changes are illustrated by histochemistry, immunocytochemistry, resin histology, and electron microscopy. The pathological findings are correlated with the clinical picture whenever possible. The interpretation of the findings is scientifically based. To facilitate this process, the fundamentals of normal histology and biology of the muscle cell are also covered.The book has been thoroughly revised and expanded for this Second Edition to provide up-to-date coverage of the relevant molecular biology and molecular genetics, as well as extensive references. It has been well organized and richly illustrated by the authors, who have been at the forefront of muscle pathology and neuromuscular research for 35 years. This practical reference work is intended for neuropathologists, neurologists, and general pathologists who look at muscle biopsies. It will also serve as an introduction to muscle disease for neurology and pathology residents.
Author : Mark Willems
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 21,34 MB
Release : 2013
Category : Muscles
ISBN : 9781624172717
It is essential for our quality of life to have healthy muscles. Tragically, the loss of even a single protein can have dramatic effects on muscle functioning and quality of life. This book is about skeletal muscles, their physiological complexity and molecular functioning in health and disease. The range of topics varies from the fascinating events at the level of the cross-bridges, the aging process of skeletal muscles, ischemia-reperfusion, inflammatory myopathies and mitochondrial function, muscular dystrophy and the regulation of skeletal muscle mass in health and disease. This book is written by internationally acclaimed researchers and expert research groups and provides state of the art understanding of the plasticity of skeletal muscle, information that is vital for health professionals who deal with diverse chronic disease conditions.
Author : George Karpati
Publisher : Cambridge University Press
Page : 800 pages
File Size : 47,56 MB
Release : 2001-07-12
Category : Medical
ISBN : 9780521650625
Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.
Author : Joseph Hill
Publisher : Academic Press
Page : 1469 pages
File Size : 20,89 MB
Release : 2012-08
Category : Medical
ISBN : 012381510X
Muscle: Fundamental Biology and Mechanisms of Disease will be the first reference covering cardiac, skeletal, and smooth muscle in fundamental, basic science, translational biology, disease mechanism, and therapeutics. Currently there are no publications covering the science behind the medicine, as the majority of books are 90% clinical and 10% science. Muscle: Fundamental Biology and Mechanisms of Disease will discuss myocyte biology, also known as muscle cell biology, providing information about the science behind clinical work and therapeutics with a 90% science and 10% clinical focus. A needed resource for researchers, clinical professionals, postdocs, and graduate students, this publication will further discuss basic biology development and physiology, how processes go awry in disease states, and how the defective pathways are targeted for therapy. This book will assist both the new and experienced clinician's and researcher's need for science translation of background research into clinical applications, bridging the gap between research and clinical knowledge.
Author : Leonid Poretsky
Publisher : Springer Science & Business Media
Page : 788 pages
File Size : 13,26 MB
Release : 2002
Category : Health & Fitness
ISBN : 9781402071140
Diabetes mellitus is a very common disease which affects approximately 150,000,000 worldwide. With its prevalence rising rapidly, diabetes continues to mystify and fascinate both practitioners and investigators by its elusive causes and multitude of This textbook is written for endocrinologists, specialists in other disciplines who treat diabetic patients, primary care physicians, housestaff and medical students. It covers, in a concise and clear manner, all aspects of the disease, from its pathogenesis on the molecular and cellular levels to its most modern therapy.
Author : Ivan Damjanov
Publisher : Elsevier Health Sciences
Page : 523 pages
File Size : 49,41 MB
Release : 2009-01-01
Category : Medical
ISBN : 032305594X
A two-color page layout, portable size, and a list of the "Top 100 Secrets" in pathology help students and residents to better meet the challenges they face today. They will find all of the features they rely on the Secret Series® for-a question-and-answer format, lists, mnemonics, and tables and an informal tone that make reference fast and easy. No matter what questions arise in practice or while preparing for boards, this 3rd Edition has the answers-in print and online. Uses bulleted lists, tables, short answers, and a highly detailed index to expedite reference. Features 20 new figures, pearls, tips, memory aids, and "secrets" from the experts. Covers all of today's most common procedures and techniques. Includes a list of the "Top 100 Secrets" to keep in mind during a rotation or residency. Features a compact, trim size (5 1/4" x 8 1/2") for enhanced portability. Makes information easier to find with a two-color page layout and "Key Points" boxes. Identifies useful websites to make it easy to find additional information on a specific topic and provides live links in the online version. Self Assessment exercises and matching Q&A for every chapter online with Student Consult to prepare for exams and focus your study on particular areas that you need the most. Includes STUDENT CONSULT access! www.studentconsult.com is an innovative website that allows you to build a personalized, fully integrated, online library, where you'll find. The entire contents of every STUDENT CONSULT title you purchase. Powerful search capabilities- View all excerpts relevant to keyword or subject searches (up to 300 words per hit) from every book in the series. Image library POCKETConsult- Download portions of your personal library onto your handheld device. Student resources- Sharpen your skills, stay informed, and have fun! More!
