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Skin Pharmacology and Toxicology

Author : Corrado L. Galli

Publisher : Springer Science & Business Media

Page : 310 pages

File Size : 47,12 MB

Release : 2012-12-06

Category : Medical

ISBN : 1468479024

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Book Description

Major skin diseases, including acne, psoriasis and eczcma, affect the majority of the population at some time in their lives. In general, these diseases are physically and psychologically disfiguring for the sufferers; furthermore, by their very chronic nature skin diseases, unlike most other disease processes, present both acute and chronic therapy problems. In addition, the chronic nature of these diseases can present certain economic problems. Firstly, chronic therapy is becoming increasingly expensive and secondly, patients adhering to a strict treatment regimen will frequently be absent from their gainful employment for either medical consultation or treatment. Given that in all NATO countries the average age of the population is continually increasing, these chronic skin diseases will increase in importance in the coming years. Furthermore, as the average population age increases, additional disease processes such as skin photodamage and carcinogenicity risk becoming major areas of therapeutic concern. This book reviews in detail the major scientific areas of interest for research and clinical scientists working in skin pharmacology and toxicology. The basic principles relating to an understanding of how drugs and chemicals may influence either the skin or the body as a whole are discussed in detail by recognized international scientific experts.



Principles and Practice of Skin Toxicology

Author : Robert Chilcott

Publisher : John Wiley & Sons

Page : 392 pages

File Size : 49,37 MB

Release : 2008-07-31

Category : Science

ISBN : 0470773081

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Book Description

Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.



Toxicology of the Skin

Author : Nancy A. Monteiro-Riviere

Publisher : CRC Press

Page : 452 pages

File Size : 49,27 MB

Release : 2010-02-17

Category : Medical

ISBN : 1420079182

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Book Description

This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barr



Pharmacology of the Skin II

Author :

Publisher : Springer Science & Business Media

Page : 602 pages

File Size : 48,55 MB

Release : 2012-12-06

Category : Medical

ISBN : 3642740545

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Book Description

The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.



Dermatotoxicology

Author : Klaus Peter Wilhelm

Publisher : CRC Press

Page : 524 pages

File Size : 31,1 MB

Release : 2012-09-27

Category : Medical

ISBN : 1841848573

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Book Description

The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international ex



Pharmacology of the Skin

Author : Hasan Mukhtar

Publisher : Springer

Page : 456 pages

File Size : 15,89 MB

Release : 1991-12-07

Category : Medical

ISBN :

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Book Description

This book presents a balanced, state-of-the-art summary of pharmacology as it relates to the skin. Topics discussed include structure of the skin and its barrier function; model systems for research in skin pharmacology; the drug metabolizing capability of the skin, skin pharmacology in health and disease; the role of oxidants and antioxidants in the skin; immunopharmacology of the skin; signal transduction, protein kinase C and the role of the eicosanoid receptors in skin; and cutaneous chemical- and photo-carcinogenesis. Pharmacology of the Skin provides essential information for investigators working in cutaneous biology, investigative and clinical dermatologists, pharmacologists, pharmacists, biochemists, and workers in the pharmaceutical industry engaged in drug development.



Pharmacology of the Skin I

Author :

Publisher : Springer

Page : 510 pages

File Size : 43,66 MB

Release : 2011-12-21

Category : Medical

ISBN : 9783642737985

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Book Description

The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin, where they may be more relevant to human physiology and diseases, as in animal models. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of etiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis-retinoic acid was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on etiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as an important step in the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.



Exogenous Dermatology

Author : Christian Surber

Publisher : S Karger Ag

Page : 0 pages

File Size : 26,16 MB

Release : 1995

Category : Medical

ISBN : 9783805560627

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Book Description

This concise collection of contributions brings together researchers from many areas of dermatology, including allergology, bioengineering and pharmacology, in commemoration of the 65th birthday of Howard I. Maibach. It reflects only a small number of the fields where Professor Maibach has made a lasting impression. Highlights of this volume include a study on an allergen bank and the ideas behind it, a comprehensive presentation of textile dye contact allergens, and the clinical standardization of the TRUE Test formaldehyde patch. Contributions in bioengineering and occupational dermatology deal with quantification of biophysical properties of the skin, irritancy exposure assessment in metal workers, and the effects of surfactants on skin hydration. A large section on skin pharmacology provides the reader with solid research data and incisive commentaries from researchers and leading authorities on issues of in vitro and in vivo percutaneous absorption, skin metabolism, topical bioavailability and bioequivalency. Dermatologists, pharmacologists and toxicologists will have much to gain from having a copy of this volume close at hand.



Skin Reactions to Drugs

Author : Kirsti Kauppinen

Publisher : CRC-Press

Page : 178 pages

File Size : 27,49 MB

Release : 1998-06-01

Category : Medical

ISBN : 9780849383762

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Book Description

Emphasising the mechanisms and clinical and laboratory proof of a cause-and-effect relationship between drugs and adverse reactions, this book discusses the technique of drug challenge, which has been extensively developed in Finland, but not commonly practiced in the rest of the world. 12 of the most common drug eruptions are described both clinically and histologically. It features a chapter on systemic contact dermatitis and also addresses cutaneous adverse drug reactions that appear in HIV-infected patients. 40 full-color photographs provide vivid examples of the reactions being discussed. A highly practical resource for practicing physicians and other health care workers.



Pharmacology of the Skin I

Author :

Publisher : Springer Science & Business Media

Page : 527 pages

File Size : 28,38 MB

Release : 2012-12-06

Category : Medical

ISBN : 3642737978

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Book Description

The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin, where they may be more relevant to human physiology and diseases, as in animal models. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of etiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis-retinoic acid was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on etiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as an important step in the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.