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Targeted Therapies for Lung Cancer

Author : Ravi Salgia

Publisher : Springer

Page : 244 pages

File Size : 30,38 MB

Release : 2019-06-26

Category : Medical

ISBN : 3030178323

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Book Description

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.





Successes and Limitations of Targeted Cancer Therapy

Author : S. Peters

Publisher : Karger Medical and Scientific Publishers

Page : 126 pages

File Size : 18,11 MB

Release : 2014-02-19

Category : Medical

ISBN : 3318025429

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Book Description

The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies.



Thoracic Malignancies

Author : Steven E. Schild, MD

Publisher : Demos Medical Publishing

Page : 260 pages

File Size : 33,48 MB

Release : 2010-03-08

Category : Medical

ISBN : 1935281801

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Book Description

Thoracic Malignancies: Thoracic Malignancies is the first title in Radiation Medicine Rounds. These tumors take more lives than any others and they are among the most preventable of tumors. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Thoracic Malignancies addresses the multi-disciplinary nature of the care of these tumors. There is representation from radiation oncology, medical oncology, and surgery ensuring a well-rounded summarization of current practice. Included are chapters on lung cancer, esophageal cancer, and thymomas providing coverage of the vast majority of thoracic tumors. The multi-disciplinary nature of the articles provides readers with an up-to-date summary and a well-rounded review regarding these tumors and their care. Expert authors provide reviews and assessments of the most recent data and its implications for current clinical practice, along with insights into emerging new trends of importance for the near future. About the Series Radiation Medicine Rounds is an invited review publication providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of radiation medicine. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Radiation Medicine Rounds provides authoritative, thorough assessments of a wide range of Ïhot topicsÓ and emerging new data for the entire specialty of radiation medicine. Features of Radiation Medicine Rounds include: Editorial board of nationally recognized experts across the spectrum of radiation medicine In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine Issues edited by an authority in specific subject area Focuses on major topics in Radiation Medicine with in-depth articles covering advances in radiation science radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcomes studies Emphasizes multidisciplinary approaches to research and practice





Exhaled Biomarkers

Author : I. Horvath

Publisher : European Respiratory Society

Page : 261 pages

File Size : 25,84 MB

Release : 2010-09-01

Category : Medical

ISBN : 1849840059

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Book Description

Exhaled air contains numerous substances, often in extremely low concentrations. The development of sensitive detection techniques has made it possible to examine the composition of exhaled air in relation to a variety of airway diseases and other disorders. In this book, an overview of current cutting-edge breath analysis techniques and their clinical applications is provided for the clinician. The various contributions give a fascinating perspective of a future where new, highly sensitive methodologies will enable clinicians to diagnose and monitor a wide variety of diseases merely by taking.



Molecular Pathology of Lung Cancer

Author : Philip T. Cagle

Publisher : Springer Science & Business Media

Page : 217 pages

File Size : 14,72 MB

Release : 2012-06-14

Category : Medical

ISBN : 1461431972

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Book Description

As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.



Lung Cancer

Author : Karen L. Reckamp

Publisher : Springer

Page : 324 pages

File Size : 25,85 MB

Release : 2016-08-17

Category : Medical

ISBN : 3319403893

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Book Description

This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer.



The MD Anderson Manual of Medical Oncology

Author : Hagop M. Kantarjian

Publisher : McGraw-Hill Prof Med/Tech

Page : 1172 pages

File Size : 20,40 MB

Release : 2006-03-22

Category : Medical

ISBN : 9780071414999

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Book Description

A concise, up-to-date clinician's guide to cancer management -- from the leaders in the field A Doody's Core Title! The MD Anderson Cancer Center is ranked as the world's leading institution in cancer medicine. With publication of the MD Anderson Manual of Medical Oncology, the editorial board of this prestigious institution makes available for the first time a resource that meets the needs of clinicians for an authoritative, accessible guide to the medical management of patients with cancer and its complications. Straight-to-the-point, state-of-the-art strategies for cancer management Gives physicians a current, coherent approach to each disease and situation -- imbued with the clinical expertise and teaching authority of world class oncology researchers/practitioners Consistently formatted for a unified patient management strategy Packed with time-saving features, including “The M.D. Anderson Work-Up Box” and “The M.D. Anderson Preferred Treatment Box” Examines special issues in breast cancer management…current treatment strategies for infection in the neutropenic patient and management of fungal and viral infections in cancer patients… basic concepts and controversies related to allogeneic marrow transplantation…more Provides guidelines for oncologic emergencies and palliative care Outlines procedures for symptom control in long-term survival… long-term follow-up in pediatric and adult patients…and rehabilitation



Manual of Clinical Oncology

Author : Bartosz Chmielowski

Publisher : Lippincott Williams & Wilkins

Page : 1151 pages

File Size : 37,51 MB

Release : 2017-02-23

Category : Medical

ISBN : 1496349598

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Book Description

Concise, portable, and packed with essential information, Manual of Clinical Oncology is an indispensable resource for understanding basic science, clinical findings, and available technology as they relate to the diagnosis and management patients with cancer. The practical format provides high-yield content useful for participating in rounds ad making diagnostic and therapeutic decisions at the bedside. Edited by Dr. Bartosz Chmielowski and Dr. Mary Territo, both from UCLA School of Medicine, this eighth edition carries on the tradition of excellence set forth by longtime editor Dr. Dennis Casciato. Incorporates recent major achievements in immunotherapies, biologics, and targeted therapies. Features new chapters on the biology of cancer, immunotherapy, and cancer survivorship. Contains numerous diagnostic and treatment algorithms, as well as content on complications, for assistance with clinical decision making. Includes helpful appendices such as a glossary of cytogenetic nomenclature and combination chemotherapy regimens. Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time — providing a seamless reading experience online or offline Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design The ability to highlight text and add notes with one click