Author : Klaus Aktories
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 38,56 MB
Release : 2007-05-02
Category : Medical
ISBN : 3540271155
With contributions by numerous experts
Author : Jorge H Leitão
Publisher :
Page : 400 pages
File Size : 43,2 MB
Release : 2020-09-04
Category :
ISBN : 9783039369461
Microbial virulence factors encompass a wide range of molecules produced by pathogenic microorganisms, enhancing their ability to evade their host defenses and cause disease. This broad definition comprises secreted products such as toxins, enzymes, exopolysaccharides, as well as cell surface structures such as capsules, lipopolysaccharides, glyco- and lipoproteins. Intracellular changes in metabolic regulatory networks, governed by protein sensors/regulators and non-coding regulatory RNAs, are also known to contribute to virulence. Furthermore, some secreted microbial products have the ability to enter the host cell and manipulate their machinery, contributing to the success of the infection. The knowledge, at the molecular level, of the biology of microbial pathogens and their virulence factors is central in the development of novel therapeutic molecules and strategies to combat microbial infections. The present collection comprises state of the art research and review papers on virulence factors and mechanisms of a wide range of bacterial and fungal pathogens for humans, animals, and plants, thus reflecting the impact of microorganisms in health and economic human activities, and the importance of the topic.
Author : K. Aktories
Publisher : Springer Science & Business Media
Page : 713 pages
File Size : 19,16 MB
Release : 2013-03-14
Category : Medical
ISBN : 3662059711
In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
Author : Thomas Proft
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 50,69 MB
Release : 2009
Category : Science
ISBN : 9781904455448
Toxins are important virulence determinants responsible for microbial pathogenicity and/or evasion of the host immune response. Understanding the molecular and cellular biology of toxins is critical for the development of new anti-toxin strategies, particularly for those with bioterrorism capability. Indeed, potential applications of toxin research extend beyond simply combating microbial virulence and include the development of novel anti-cancer drugs and other frontline medicines, use of toxins as tools in neurobiology and cellular biology, etc. This timely volume serves as an update on important recent advances. Written by internationally respected scientists, topics reviewed include: toxins carried by mobile genetic elements, botulinum neurotoxins, anthrax, subtilase cytotoxin, Pasteurella multocida toxin, RTX toxins of vibrios, vacA toxin, staphylococcal immune evasion toxins, and fungal ribotoxins. The book is essential reading for everyone with an interest in microbial toxins, and it is recommended for other scientists with an interest in microbiology, bioterrorism, microbial pathogenesis, and microbial genomics.
Author : P. Gopalakrishnakone
Publisher : Springer
Page : 0 pages
File Size : 34,60 MB
Release : 2016-03-14
Category : Medical
ISBN : 9789400764187
In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.
Author : Holger Barth
Publisher : MDPI
Page : 125 pages
File Size : 37,94 MB
Release : 2018-07-09
Category : Science
ISBN : 3038424307
This book is a printed edition of the Special Issue "Novel Pharmacological Inhibitors for Bacterial Protein Toxins" that was published in Toxins
Author :
Publisher :
Page : 0 pages
File Size : 26,23 MB
Release : 2002
Category : Cells
ISBN : 9780815332183
Author :
Publisher : Academic Press
Page : 643 pages
File Size : 48,55 MB
Release : 1998-07-01
Category : Science
ISBN : 0080860567
Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. - Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease - Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow - Covers safety aspects, detection, identification and speciation - Includes techniques for the study of host interactions and reactions in animals and plants - Describes biochemical and molecular genetic approaches - Essential methods for gene expression and analysis - Covers strategies and problems for disease control
Author : Hemen Sarma
Publisher : Elsevier
Page : 713 pages
File Size : 44,20 MB
Release : 2022-01-08
Category : Science
ISBN : 032385981X
Emerging Contaminants in the Environment: Challenges and Sustainable Practices covers all aspects of emerging contaminants in the environment, from basic understanding to different types of emerging contaminants and how these threaten organisms, their environmental fate studies, detection methods, and sustainable practices of dealing with contaminants. Emerging contaminant remediation is a pressing need due to the ever-increasing pollution in the environment, and it has gained a lot of scientific and public attention due to its high effectiveness and sustainability. The discussions in the book on the bioremediation of these contaminants are covered from the perspective of proven technologies and practices through case studies and real-world data. One of the main benefits of this book is that it summarizes future challenges and sustainable solutions. It can, therefore, become an effective guide to the elimination (through sustainable practices) of emerging contaminants. At the back of these explorations on sustainable bioremediation of emerging contaminants lies the set of 17 goals articulated by the United Nations in its 2030 Agenda for Sustainable Development, adopted by all its member states. This book provides academics, researchers, students, and practitioners interested in the detection and elimination of emerging contaminants from the environment, with the latest advances by leading experts in emerging contaminants the field of environmental sciences. - Covers most aspects of the most predominant emerging contaminants in the environment, including in soil, air, and water - Describes the occurrence of these contaminants, the problems they cause, and the sustainable practices to deal with the contaminants - Includes data from case studies to provide real-world examples of sustainable practices and emerging contaminant remediation
Author : Liang Wang
Publisher : BoD – Books on Demand
Page : 184 pages
File Size : 27,22 MB
Release : 2024-02-28
Category : Medical
ISBN : 1803567082
Bacterial biofilm is a complex structure with diverse bacterial cells in a highly organized and ordered group within a matrix of extracellular polymeric substances they produce. Microbes attach to surfaces to develop biofilms, a sophisticated process regulated by factors such as nutritional status and biotic/abiotic surface features. An established biofilm structure mainly comprises bacterial cells, proteins, nucleic acid, and exo-polysaccharides that are extracellular macromolecules excreted as tightly bound layers in microbes, providing a perfect niche for bacteria to exchange genetic material between cells. In addition, bacterial cells in the matrix also communicate via quorum sensing, which greatly impacts biofilm processes. Under clinical circumstances, bacterial biofilm shows great resistance to antibiotics, disinfectants, and body defense systems, making it difficult for clinicians to eradicate and facilitate many infectious disease processes, leading to chronic infections of patients with long-term hospitalization and high mortality rates. Therefore, it is very important to understand the recent advances in forming, regulating, and eradicating biofilms in human infections to better prevent, control, and treat biofilm infections in humans. Written by an international team of basic and clinical researchers, the chapters of this book provide novel insights and advanced knowledge for life science researchers, clinical researchers, doctors, and other interested readers on some of the latest developments in biofilms.
