Stimulus Properties of Drugs


Book Description

Behavioral pharmacology represents a relatively recent scientific enterprise, the development of which can be followed by plotting the publication of major conceptual papers, review articles, and books. Dews (1955), Sidman (1955), and Brady (1956) published some of the first methodologically significant papers, changing the way both psychologists and pharmacologists viewed the analysis of the behavioral actions of drugs. Dews and Morse (1961), Cook and Kelleher (1963), Gollub and Brady (1965), and Weiss and Laties (1969) kept the field abreast of major developments in the study of behavioral mechanisms of drug action. In 1968, the first textbook in the field was published (Thompson and Schuster), followed by a book of readings covering the preceding 15 years of the field (Thompson, Pickens, and Meisch, 1970). The first attempt to outline a set of generalizations concerning behavioral mechanisms of drug actions was puhlished in 1968 by Kelleher and Morse. As behavioral pharmacology developed, it became clear that demonstrations that drugs affect hehavior were relatively uninteresting. It was the mechanisms by which these effects are hrought about that was of concern. While other aspects of pharmacology have been concerned with biochemical, physiological, and in some cases biophysical accounts of drug actions, behavioral pharmacology has dealt with behavioral mechanisms . . . that is, "any verifiable description of a drug's effects which can he shown to uniquely covary with a specific measured 'response'. Generally, this relation can be subsumed under some more general set of relations or principles" (Thompson, Pickens, and Meisch, 1970, p. I).




Discriminative Stimulus Properties of Drugs


Book Description

As one who has gone down the wayward path from "pure" organic chemistry to biochemistry to pharmacology, I was not quite prepared to go all the way - into the field of discriminable stimuli. The organizer of the symposium on discriminable stimuli induced by drugs, Dr. Harbans Lal, did seduce me into attending. Having lost my behavioral virginity, I now stare with open eyes at the field. One item in particular at this meeting exemplifies to me the power of such techniques. Dr. Albert Weissman mentioned the problem he tackled with getting rats to discriminate between saline and dilute solutions of aspirin. Under ordinary circumstances, the animals could not perform this task. However, if the animals were sensitized by injection of prostaglan din into their foot pads, then they were capable of discriminating even very dilute solutions of aspirin. In a sense, Al had created a model of the human arthritic who can jolly well tell if you have given him an aspirin or a salt tablet. The reader of this volume will find it a good introduction to the utilization of discriminable stimuli induced by drugs. After a preface by the organizer, two experts discuss basic principles in separate chapters. One of these chapters places emphasis on the drugs; the other places emphasis on the induced cues and states.




Stimulus Properties of Drugs


Book Description
















Psychotropic Agents


Book Description

The description of the pharmacology of psychotomimetics, cannabis, and alcohol in this third volume concludes the discussion on psychotropic agents. As psychomotor stimulants these groups of psychotropic agents are of little or no therapeutic relevance, but since they are used in a nonmedical manner, or are even considered by some groups of the population as social commodities, their behavioral effects and psychopharmacological properties are not the concern of the pharmacol ogist alone. The same is true of psychotomimetics, as well as cannabis and its components. Psychotomimetics have a social history going back many hundreds of years and are among the most potent psychotropic agents known to man. The closing description of psychopharmacology also deals with the psychotropic effects of a number of drugs not primarily considered to be psychotropic. Their psychotropic effects are either an inherent constituent of their therapeutic profile, as is the case with opiates, hypnotics, and caffeine, or they may occur indirectly as side effects or accompanying effects during therapy. This applies to p-adrenoreceptor antagonists and anticholinergics. The editors are also aware that a description of psychotropic agents would not have been complete without discussing the medical, ethical, and legal aspects of the development, clinical testing, and use of such drugs.




National Union Catalog


Book Description

Includes entries for maps and atlases.