Strategies for Immunointerventions in Dermatology


Book Description

Recent progress in the fields of pharmacology and immunology has provided us with new possibilities for treating dermatological diseases. This book reviews the most important immunosuppressive and immunostimulatory drugs and gives helpful, practical information on the treatment of various dermatoses, including autoimmundiseases, atopic dermatitis, psoriasis, vasculitis, contact dermatitis, pyoderma gangrenosum, infectious diseases, and neoplasms of the skin - in particular, malignant melanoma.




Strategies for immunointerventions in dermatology


Book Description

Overview of the substances and drugs currently in use which show immunostimulatory or immunosuppressive effects. Gives practical information on the treatment of various dermatoses.




Treatment of Skin Disease E-Book


Book Description

Treatment of Skin Disease is your definitive source for managing the complete range of dermatologic conditions you’re likely to encounter in practice. This medical reference book boasts an intuitive and easy to use format that covers the full spectrum of options, equipping you with not only standard treatment strategies, but second- and third-line therapies for instances when other alternatives fail. You’ll be thoroughly prepared to offer your patients the expertly informed medical care they deserve when facing common or complex dermatologic diseases. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Address your most difficult clinical challenges by having every possible therapy option at your disposal, including third- and fourth-line therapies, as well as standard treatments for dermatologic disorders. Apply the in-depth knowledge of leading dermatologists through a summary of each treatment strategy along with detailed discussions of treatment choices. Gain insight to the essential features which define each dermatologic disease with chapters presented in a tabular format, using checklists of diagnostic and investigative pearls and color-coded boxed text, for quick at-a-glance summaries of key details. Make the most informed decisions possible with the inclusion of up-to-date evidence levels throughout the text. Stay abreast of emerging drug treatments and research with the very latest options for the 251 most common dermatologic conditions, and take advantage of today’s expert knowledge on hot topics in dermatology such as bed bugs, erosive pustular dermatosis, polycystic ovary syndrome, and more. Achieve effective visual diagnoses by viewing over 250 full-color clinical images of skin diseases, most of which are brand new in this edition.




Dermatologic Immunity


Book Description

Nickeloff (skin cancer research, Cardinal Bernardin Cancer Center, Chicago) and Nestle (cutaneous medicine and immunotherapy, King's College, London School of Medicine at Guy's, UK) assemble 19 review articles on autoimmune disease processes that affect the skin, covering both humoral and cellular immunity. The etiology, cellular and molecular mechanisms, therapeutic strategies, and pathophysiology of diseases such as psoriasis, dermatitis, cutaneous lupus erythematosus, vitiligo, and scleroderma are discussed by individuals in dermatology, genetics, immunology, and pathology who are based around the world. The book is aimed at clinical researchers, students, allergists, immunologists, dermatologists, and internists.




Treatment of Skin Disease


Book Description

This title provides an evidence-based approach to third- and fourth-line dermatologic therapies as well as to standard approaches. Although common diseases, such as psoriasis and eczema are covered, the book emphasizes therapeutically difficult diseases. It is organized by disease and briefly reviews diagnostic criteria before covering the first-, second-, third-, and fourth-line therapies. Within each therapeutic level, the therapies are ranked by efficacy and supporting evidence. This is an innovative book that combines evidence-based medicine with an easily accessible format. "Without doubt this is an excellent book and the reader is encouraged to dip in and read around a topic and enhance their knowledge. It is also a super reference book, particulary when wanting more information about dermatological therapeutics - an area that is often neglected". Reviewed by: Dr Harry Brown Date: April 2014 Fully covers treatment of 250 diseases, both common and therapeutically awkward, providing all the dermatologist needs in one volume. Covers all the therapeutic options, even third and fourth-line therapies - try this when all else fails. Organized alphabetically by disease and in an accessible tabular format for quick reference. Takes an evidence-based approach acknowledging anecdote as such, giving you the hard information that you need to make therapeutic decisions. Each chapter written to a template - you'll know your way around this text in no time. Full-color, key clinical photo of each disease giving the most accurate representation of a disease possible. Logically organized , with checklists of diagnostic and investigative pearls helping you to quickly verify that your diagnosis is correct. A summary of each treatment option, before detailed discussion, allows you to quickly refresh your knowledge when in a hurry. Editors offer their expert commentary on each treatment strategy. The references are annotated immediately providing information which would normally have to be sought on Medline. International team (25% European) of 250 experts present treatment options from all over the globe. The perfect companion wherever you practice - American drug names are given first, with European names in brackets afterwards. Also included: a full, international drug name glossary. The text is extensively cross-referenced avoiding duplication of information about drugs under several different diagnoses. Includes a modern, evidence-based /bilateral controlled-trial approach so you know what's anecdote and what is received fact.




Disease Control Priorities in Developing Countries


Book Description

Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.




SITC’s Guide to Managing Immunotherapy Toxicity


Book Description

The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer




Skin and Arthropod Vectors


Book Description

Recent research on skin immunity and the skin microbiome reveals the complexity of the skin and its importance in the development of immunity against arthropod-borne diseases. In diseases such as malaria, borreliosis, leishmaniasis, trypanosomiasis, etc., the skin interface has been shown as an essential site for pathogens to hide from the immune system, and as a potential site of persistence. Only very few vaccines have been successfully developed so far against these diseases, likely because of an insufficient understanding on the development of skin immunity against pathogens. Skin and Arthropod Vectors expands our knowledge on the role of the skin interface during the transmission of arthropod-borne diseases and particularly its immunity. This work may support researchers who strive for developing more efficient diagnostic tools and vaccines. It also gives scientists and advanced students working in related areas a better insight on how humans and animals are attractive to arthropods to develop better repellents, or to set up transgenic arthropods. Offers the only compilation of research focusing on both the skin interface and arthropod vectors, with contributions from international experts Advances research in the effort toward generating more effective diagnostic tools and vaccines focusing on the skin interface Can also serve as supplemental material for dermatology lectures or specialized lectures on medical entomology and skin immunity




Immunotherapy


Book Description

The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. While immunotherapy has revolutionized the treatment landscape of several solid malignancies, several challenges still exist. Only a subset of patients derive clinical benefits; some do not respond at all, and others respond initially, only for their disease to progress later. Because these drugs can activate a broad range of immune cells, patients suffer from a unique set of side effects known as immune-related adverse events. As more immunotherapeutic agents are used in the clinic, it is important to provide updates about current and ongoing developments in the field to further research efforts and inform treatment decisions. The fourth edition will have a new focus on strategies to overcome the challenges associated with immunotherapy. Chapters will discuss topics such as biomarkers of response, resistance mechanisms, role of imaging in predicting immune-related adverse events, and management of immune-related adverse events. Written by leading experts conducting cutting-edge research, readers will gain up-to-date knowledge on the current state and future of immunotherapy.




Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book


Book Description

From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.