Study of the Mechanisms Involved in the Pathogenesis of Foreign-Body Infections Caused by Coagulase-Negative Staphylococci


Book Description

"General introduction, Quantification of the expression of Staphylococcus epidermidis housekeeping genes with Taqman quantitative PCR during in vitro growth and under different conditions, Use of gDNA as internal standard for gene expression in Staphylococci in vitro and in vivo, The effect of systemic administration of antibiotics on quantitative culture of explanted catheters, Housekeeping gene expression in Staphylococcus epidermidis during in vitro and in vivo foreign body infections, Expression of biofilm-associated genes in Staphylococcus Epidermidis during in vitro and in vivo foreign body infections, Reliability of the ica, aap and atlE genes in the discrimination between invasive, colonizing and contaminant Staphylococcus epidermidis isolates in the diagnosis of catheter-related infections, Discussions."







New Strategies for the Treatment of Coxsackievirus-induced Myocarditis


Book Description

This is a Ph.D. dissertation. Coxsackieviruses B (CBV) are considered to be the principal etiological agent of viral myocarditis. In analogy to many other viral illnesses, both direct viral injury as well as the immune response plays an important role in the pathogenesis of viral heart disease. At the present moment not a single specific therapeutic agent is available for the treatment of CVB-induced myocarditis. The main goal of this work was to explore new strategies for the treatment of viral myocarditis based on the current scientific knowledge about the pathogenesis of this disease.




Pet-to-Man Travelling Staphylococci


Book Description

Pet-to-Man Travelling Staphylococci: A World in Progress explores Staphylococci, a dangerous pathogen that affects both humans and animals with a wide range of infection states. This bacteria can spread rapidly as a commensal organism in both humans and pets, and is an agent of disease. Staphylococci are potentially highly virulent pathogens which require urgent medical attention. In addition, Staphylococci remain a threat within hospital environments, where they can quickly spread across a patient population. This book explores the organisms' resistance to many compounds used to treat them, treatment failure and multidrug resistant staphylococci, amongst other related topics. - Focuses not only on man and animal staphylococcal diseases, but on the role of shared household in man-to-pet (and vice versa) transmission - Underlines the importance of professional exposure to mammals (i.e. veterinary and farm personnel) in the establishment of shared colonization's and related diseases - Highlights the impact of shared staphylococci and virulence determinants in human and veterinary pathology - Sheds light on the way staphylococci may be recognized in clinical laboratories







Pathogenesis of Hemodynamic Changes During Raised Intracranial Pressure


Book Description

"Cerebral cardiovascular control: anatomical and physiological aspects, Catecholamine response to a gradual increase of ICP, Course of ICP changes in two models of progressive intracranial hypertension, Pathogenetic aspects of the hemodynamic changes during raised intracranial pressure, Summary and Conclusions."







Staphylococci in Human Disease


Book Description

Staphylococci remain the most important cause of hospital-acquiredinfections in the U.S. and MRSA has become the most common cause ofskin and soft tissue infection in many parts of the world. There is now a much greater understanding of the physiology andevolution of the staphylococci and this new edition reflects therapid advancements in knowledge about this pathogen and provides acomprehensive review from both clinical and basic scienceperspectives. The first section addresses the basic biology of thestaphylococci, their molecular genetics, host defenses and hostevasion, virulence determinants, mechanisms of antibioticresistance, and laboratory techniques. The second section dealswith epidemiology, and the third section provides an overview ofthe varied clinical manifestations of human staphylococcalinfections. The fourth section covers prevention and treatment ofthese often life-threatening infections. Written by experts from around the globe, this book is essentialreading for all clinicians and basic scientists studying thestaphylococci.




Prosthetic Joint Infections


Book Description

This book outlines the most updated clinical guidelines that are vital for the prevention infections and care of patients with joint infections following a replacement surgery, one of the highest volume medical interventions globally. Sections address the diagnosis, management approaches and prevention of prosthetic joint infections. Written by experts in the field, this text provides a brief overview of the literature and current recommendations in each of the specified areas. Given the rapidly evolving state-of-play in this clinical area, this compendium grows increasingly important to clinicians in their management decisions. Prosthetic Joint Infections is a valuable resource for infectious disease specialists, epidemiologists, surgeons, and orthopedic specialists who may work with patients with prosthetic joint infections.