Applied Meta-Analysis with R


Book Description

In biostatistical research and courses, practitioners and students often lack a thorough understanding of how to apply statistical methods to synthesize biomedical and clinical trial data. Filling this knowledge gap, Applied Meta-Analysis with R shows how to implement statistical meta-analysis methods to real data using R. Drawing on their extensive research and teaching experiences, the authors provide detailed, step-by-step explanations of the implementation of meta-analysis methods using R. Each chapter gives examples of real studies compiled from the literature. After presenting the data and necessary background for understanding the applications, various methods for analyzing meta-data are introduced. The authors then develop analysis code using the appropriate R packages and functions. This systematic approach helps readers thoroughly understand the analysis methods and R implementation, enabling them to use R and the methods to analyze their own meta-data. Suitable as a graduate-level text for a meta-data analysis course, the book is also a valuable reference for practitioners and biostatisticians (even those with little or no experience in using R) in public health, medical research, governmental agencies, and the pharmaceutical industry.




Applied Meta-Analysis with R and Stata


Book Description

Review of the First Edition: The authors strive to reduce theory to a minimum, which makes it a self-learning text that is comprehensible for biologists, physicians, etc. who lack an advanced mathematics background. Unlike in many other textbooks, R is not introduced with meaningless toy examples; instead the reader is taken by the hand and shown around some analyses, graphics, and simulations directly relating to meta-analysis... A useful hands-on guide for practitioners who want to familiarize themselves with the fundamentals of meta-analysis and get started without having to plough through theorems and proofs. —Journal of Applied Statistics Statistical Meta-Analysis with R and Stata, Second Edition provides a thorough presentation of statistical meta-analyses (MA) with step-by-step implementations using R/Stata. The authors develop analysis step by step using appropriate R/Stata functions, which enables readers to gain an understanding of meta-analysis methods and R/Stata implementation so that they can use these two popular software packages to analyze their own meta-data. Each chapter gives examples of real studies compiled from the literature. After presenting the data and necessary background for understanding the applications, various methods for analyzing meta-data are introduced. The authors then develop analysis code using the appropriate R/Stata packages and functions. What’s New in the Second Edition: Adds Stata programs along with the R programs for meta-analysis Updates all the statistical meta-analyses with R/Stata programs Covers fixed-effects and random-effects MA, meta-regression, MA with rare-event, and MA-IPD vs MA-SS Adds five new chapters on multivariate MA, publication bias, missing data in MA, MA in evaluating diagnostic accuracy, and network MA Suitable as a graduate-level text for a meta-data analysis course, the book is also a valuable reference for practitioners and biostatisticians (even those with little or no experience in using R or Stata) in public health, medical research, governmental agencies, and the pharmaceutical industry.




Study Max


Book Description

The difference between students who do well in school and those who struggle usually comes down to one thing-effectiveness in their learning and studying strategies. The Study Max program provides high school teachers with a step-by-step method for helping all students capitalize on their learning strengths to become fully engaged learners.




Study Guide to Epidemiology and Biostatistics


Book Description

Help your students understand some of the most elusive fundamentals of epidemiology and biostatistics with this fully updated revision of the bestselling Study Guide to Epidemiology and Biostatistics. The Seventh Edition offers expanded chapters as well as coverage of new topics that have become prevalent in the medical literature such as: receiver-operator curve analysis to improve sensitivity/specificity; the power of a statistical test; one-tailed P values; comparison-wise significance levels versus study-wise significance levels; confidence interval and its relationship to statistical significance; meta-analysis with current methods for assessing heterogeneity and the potential for publication bias; and the use of propensity scoring to reduce bias in non-experimental studies. Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.




Indacaterol


Book Description

Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available. This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled β2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.




Artificial Intelligence in Education


Book Description

This book constitutes the refereed proceedings of the 18th International Conference on Artificial Intelligence in Education, AIED 2017, held in Wuhan, China, in June/July 2017. The 36 revised full papers presented together with 4 keynotes, 37 poster, presentations, 4 doctoral consortium papers, 5 industry papers, 4 workshop abstracts, and 2 tutorial abstracts were carefully reviewed and selected from 159 submissions. The conference provides opportunities for the cross-fertilization of approaches, techniques and ideas from the many fields that comprise AIED, including computer science, cognitive and learning sciences, education, game design, psychology, sociology, linguistics as well as many domain-specific areas.




Rosen's Emergency Medicine - Concepts and Clinical Practice, 2-Volume Set,Expert Consult Premium Edition - Enhanced Online Features and Print,7


Book Description

This reference places the latest information at users' fingertips, and a more streamlined format makes it easy to find the exact information quickly and conveniently. Includes access to a companion Web site for additional resources.




The Scientific Study of Personal Wisdom


Book Description

The rich and diverse contributions to this volume span a wide variety of disciplines, from psychology and philosophy to neuroscience, by some of the most influential scholars in the emerging science of personal wisdom. As such, it is a collection of essential readings and the first publication to integrate both the spiritual and pragmatic dimensions of personal wisdom. The content of the book goes beyond speculative theory to present a wealth of scientific research currently under way in this expanding field. It also describes numerous promising methods now being deployed in the quest for scientific knowledge of the elusive, yet critical, phenomenon of personal wisdom. The book is an excellent introduction to the field for novice researchers as well as a stimulating and enlightening resource for established experts. Its broad appeal makes it a vital addition to the libraries of academics and practitioners in many disciplines, from developmental psychology to gerontology and from philosophy to contemplative religious traditions such as Buddhism.




Statistics in Psychology Using R and SPSS


Book Description

Statistics in Psychology covers all statistical methods needed in education and research in psychology. This book looks at research questions when planning data sampling, that is to design the intended study and to calculate the sample sizes in advance. In other words, no analysis applies if the minimum size is not determined in order to fulfil certain precision requirements. The book looks at the process of empirical research into the following seven stages: Formulation of the problem Stipulation of the precision requirements Selecting the statistical model for the planning and analysis The (optimal) design of the experiment or survey Performing the experiment or the survey Statistical analysis of the observed results Interpretation of the results.




Phase II Clinical Development of New Drugs


Book Description

This book focuses on how to appropriately plan and develop a Phase II program, and how to design Phase II clinical trials and analyze their data. It provides a comprehensive overview of the entire drug development process and highlights key questions that need to be addressed for the successful execution of Phase II, so as to increase its success in Phase III and for drug approval. Lastly it warns project team members of the common potential pitfalls and offers tips on how to avoid them.