Suicide: Phenomenology and Neurobiology


Book Description

This book addresses the phenomenology, demographics, and neurobehavioral aspects of suicidal behavior and its risk factors, underscoring common neurobehavioral threads among different approaches which may underlie such extreme behavior. It additionally provides an overview of new approaches, such as imaging techniques to identify at-risk individuals or in response to drug treatment associated with suicidal behavior, neurodevelopmental approaches, genetic and epigenetic linkages to suicidal behavior, animal models of specific risk factors, as well as potential biomarkers being employed to help assess risk.




Advanced Issue Resolution in Safety Pharmacology


Book Description

Advanced Issue Resolution in Safety Pharmacology not only discusses unique issues that may emerge during the development of new medicines, but also provides detailed insights on how to resolve them. The book employs a valuable strategy that integrates preclinical findings with the clinical resolution of those findings. In addition, it introduces key interdisciplinary topics in an accessible and systematic format. Edited and written by leaders in the field of safety pharmacology, this book considerably advances the discussion on issue resolution topics, thus raising them to the next level of importance by providing scientists with an indispensable resource on solving safety issues. - Focuses on pharmacology issues that result during drug development and provides de-risking techniques and practical advice - Covers a broad selection of topics, including specialized animal models, PBPK modeling, the use of high frequency EEG in problem-solving, drug-induced self-injury, abuse potential liability, biomarkers, imaging, and much more - Focuses on the resolution of these issues in order to better address regulatory expectancies and develop safer, more effective drugs




Assessments, Treatments and Modeling in Aging and Neurological Disease


Book Description

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer's, stroke and multiple sclerosis. - Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging - Features sections on diagnosis and biomarkers of neurological aging, Alzheimer's and stroke - Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables




Compassionate School Practices


Book Description

Already Ready For What Will Come - SEL For A Culture Of Care Is your school prepared to care for all of the students, staff, and families in your community? Sadly, your school might be the only point of care for many. Be already ready--Establish a compassionate cultural foundation for strong relationships and holistic skills to weather stress, trauma, and promote well-being for your entire school population. Help your school or district use available resources to create a compassionate culture of justice and care for all by leaning into this book’s approach to leadership and social emotional learning. Discover a collaborative visioning process to elevate compassion through dialogue, policies, and protocol. Readers will find: Practical strategies for working with parents and communities Activities for the whole school An implementation framework for elementary, middle, and high school Deeper understanding of trauma, ACEs, and mental health concerns Support for teachers’ mental health What not to do – practices that don’t work, and why In-depth case studies and vignettes Read this and usher in transformational and compassionate change that may be the difference in whatever today, tomorrow, or the next day may bring.




Understanding the Complex Phenomenon of Suicide: From Research to Clinical Practice


Book Description

Suicide is undoubtedly a worldwide major challenge for the public health. It is estimated that more than 150,000 persons in Europe die as a result of suicide every year and in several European countries suicide represents the principal cause of death among young people aged 14–25 years. It is true that suicide is a complex (and yet not fully understood) phenomenon and may be determined by the interaction between various factors, such as neurobiology, personal and familiar history, stressful events, sociocultural environment, etc. The suicide is always a plague for the population at risk and one of the most disgraceful events for a human being. Moreover, it implies a lot of pain often shared by the relatives and persons who are close to suicide subjects. Furthermore, it has been widely demonstrated that the loss of a subject due to suicide may be one of the most distressing events that may occur in mental health professionals resulting in several negative consequences, such as burnout, development of psychiatric symptoms and lower quality of life and work productivity. All considered, it is clear that the suicide prevention is a worldwide priority and every effort should be made in order to improve the early recognition of imminent suicide, manage suicidal subjects, and strengthen suicide prevention strategies. In our opinion, the first step of prevention is the improvement of knowledge in the field: this was the aim of this present special issue on Frontiers in Psychiatry. In this special issue, several papers have contributed to the suicide knowledge from several viewpoints and we hope that this will contribute to improve and disseminate knowledge on this topic.










Adverse Childhood Experiences and Their Life-Long Impact


Book Description

Adverse Childhood Experiences and Their Life-Long Impact explores how these experiences influence cognitive, behavioral and social experiences in adulthood. The book conceptualizes the types of violence, abuse, neglect, and/or trauma that factor into ACEs. It also explores the psychopathological outcomes of ACEs among children, including neurodevelopmental and psychosocial mechanisms. By drawing on cross-cultural perspectives, the authors provide insight into the variations between the adversity and trauma children experience. Sections also cover preventive measures, risk factors and various forms of interventional treatment, making this book a core read for psychologists, physicians, social workers, educators and researchers in the field. - Provides a comprehensive framework for understanding adverse childhood experiences - Reviews the link between ACE and homelessness, substance abuse, and physical and/or sexual violence in adulthood - Highlights key components of cross-cultural perceptions on child abuse and neglect, including differences of gender - Explores options for prevention and intervention for those who experience adverse childhood experiences




Discourses of Men’s Suicide Notes


Book Description

Deaths by suicide are high: every 40 seconds, someone in the world chooses to end their life. Despite acknowledgement that suicide notes are social texts, there has been no book which analyzes suicide notes as discursive texts and no attempt at a qualitative discourse analysis of them. Discourses of Men's Suicide Notes redresses this gap in the literature. Focussing on men and masculinity and anchored in qualitative discourse analysis, Dariusz Galasinski responds to the need for a more thorough understanding of suicidal behaviour. Culturally, men have been posited to be 'masters of the universe' and yet some choose to end their lives. This book takes a qualitative approach to data gathered from the Polish Corpus of Suicide Notes, a unique repository of over 600 suicide notes, to explore discourse from and about men at the most traumatic juncture of their lives. Discussing how men construct suicide notes and the ways in which they position their relationships and identities within them, Discourses of Men's Suicide Notes seeks to understand what these notes mean and what significance and power they are invested with.




Suicide in Schizophrenia


Book Description

Why an entire volume on suicide in schizophrenia? It would appear that international literature already provides enough information in this field. Also, the daily growing number of papers on suicide among schizophrenic are certainly a more updated source of information may contribute to the reduction of deaths by suicide among these patients. Yet, as in the case of suicide as a whole, this progress of knowledge does not match with reduction of suicide rates, let alone reduction of suicide rates among people with schizophrenia. Maybe a summary, an overview that cannot be achieved with a simple Medline search may help those who are involved and those who should be involved in the prevention of self-killing of schizophrenic patients. This book, therefore, reports essays of some of the opinion leaders in the field with the aim to shed light to such overwhelming phenomenon.