Supplement to the Carcinogenic Potency Database
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Page : 130 pages
File Size : 40,3 MB
Release : 1999
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Page : 130 pages
File Size : 40,3 MB
Release : 1999
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Page : 130 pages
File Size : 29,27 MB
Release : 1999
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Page : 152 pages
File Size : 48,34 MB
Release : 1999
Category : Carcinogenicity testing
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Page : 326 pages
File Size : 29,8 MB
Release : 1995
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Page : 326 pages
File Size : 23,74 MB
Release : 1995
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Page : 0 pages
File Size : 37,90 MB
Release : 1999
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Page : 348 pages
File Size : 32,61 MB
Release : 1995
Category : Biological assay
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Author : L. S. Gold
Publisher : DIANE Publishing
Page : 130 pages
File Size : 18,43 MB
Release : 2000-03
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ISBN : 0788185365
Papers include: supp. to the carcinogenic potency database (CPD): results of animal bioassays published in 1993 to 1994; supplemental plot of the CPD; workshop on characterizing the effects of endocrine disruptors on human health at environmental exposure levels; an approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults; evaluating the effects of endocrine disruptors on endocrine function during development; and species, interindividual, and tissue specificity in endocrine signaling. Illustrated.
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Page : 0 pages
File Size : 46,79 MB
Release : 1995
Category : Biological assay
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Author : Lois Swirsky Gold
Publisher : CRC Press
Page : 840 pages
File Size : 12,18 MB
Release : 1996-11-26
Category : Medical
ISBN : 9781439810644
This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.