The Handbook of Research Synthesis and Meta-Analysis


Book Description

Research synthesis is the practice of systematically distilling and integrating data from many studies in order to draw more reliable conclusions about a given research issue. When the first edition of The Handbook of Research Synthesis and Meta-Analysis was published in 1994, it quickly became the definitive reference for conducting meta-analyses in both the social and behavioral sciences. In the third edition, editors Harris Cooper, Larry Hedges, and Jeff Valentine present updated versions of classic chapters and add new sections that evaluate cutting-edge developments in the field. The Handbook of Research Synthesis and Meta-Analysis draws upon groundbreaking advances that have transformed research synthesis from a narrative craft into an important scientific process in its own right. The editors and leading scholars guide the reader through every stage of the research synthesis process—problem formulation, literature search and evaluation, statistical integration, and report preparation. The Handbook incorporates state-of-the-art techniques from all quantitative synthesis traditions and distills a vast literature to explain the most effective solutions to the problems of quantitative data integration. Among the statistical issues addressed are the synthesis of non-independent data sets, fixed and random effects methods, the performance of sensitivity analyses and model assessments, the development of machine-based abstract screening, the increased use of meta-regression and the problems of missing data. The Handbook also addresses the non-statistical aspects of research synthesis, including searching the literature and developing schemes for gathering information from study reports. Those engaged in research synthesis will find useful advice on how tables, graphs, and narration can foster communication of the results of research syntheses. The third edition of the Handbook provides comprehensive instruction in the skills necessary to conduct research syntheses and represents the premier text on research synthesis. Praise for the first edition: "The Handbook is a comprehensive treatment of literature synthesis and provides practical advice for anyone deep in the throes of, just teetering on the brink of, or attempting to decipher a meta-analysis. Given the expanding application and importance of literature synthesis, understanding both its strengths and weaknesses is essential for its practitioners and consumers. This volume is a good beginning for those who wish to gain that understanding." —Chance "Meta-analysis, as the statistical analysis of a large collection of results from individual studies is called, has now achieved a status of respectability in medicine. This respectability, when combined with the slight hint of mystique that sometimes surrounds meta-analysis, ensures that results of studies that use it are treated with the respect they deserve....The Handbook of Research Synthesis is one of the most important publications in this subject both as a definitive reference book and a practical manual."—British Medical Journal When the first edition of The Handbook of Research Synthesis was published in 1994, it quickly became the definitive reference for researchers conducting meta-analyses of existing research in both the social and biological sciences. In this fully revised second edition, editors Harris Cooper, Larry Hedges, and Jeff Valentine present updated versions of the Handbook's classic chapters, as well as entirely new sections reporting on the most recent, cutting-edge developments in the field. Research synthesis is the practice of systematically distilling and integrating data from a variety of sources in order to draw more reliable conclusions about a given question or topic. The Handbook of Research Synthesis and Meta-Analysis draws upon years of groundbreaking advances that have transformed research synthesis from a narrative craft into an important scientific process in its own right. Cooper, Hedges, and Valentine have assembled leading authorities in the field to guide the reader through every stage of the research synthesis process—problem formulation, literature search and evaluation, statistical integration, and report preparation. The Handbook of Research Synthesis and Meta-Analysis incorporates state-of-the-art techniques from all quantitative synthesis traditions. Distilling a vast technical literature and many informal sources, the Handbook provides a portfolio of the most effective solutions to the problems of quantitative data integration. Among the statistical issues addressed by the authors are the synthesis of non-independent data sets, fixed and random effects methods, the performance of sensitivity analyses and model assessments, and the problem of missing data. The Handbook of Research Synthesis and Meta-Analysis also provides a rich treatment of the non-statistical aspects of research synthesis. Topics include searching the literature, and developing schemes for gathering information from study reports. Those engaged in research synthesis will also find useful advice on how tables, graphs, and narration can be used to provide the most meaningful communication of the results of research synthesis. In addition, the editors address the potentials and limitations of research synthesis, and its future directions. The past decade has been a period of enormous growth in the field of research synthesis. The second edition Handbook thoroughly revises original chapters to assure that the volume remains the most authoritative source of information for researchers undertaking meta-analysis today. In response to the increasing use of research synthesis in the formation of public policy, the second edition includes a new chapter on both the strengths and limitations of research synthesis in policy debates




Cyclic Nucleotide Phosphodiesterases in Health and Disease


Book Description

Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph




Metalloenzymes


Book Description

Metalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applications. After a brief overview, international experts in the field discuss a wide range of magnesium, calcium, zinc, manganese, nickel, iron, copper, cadmium, molybdenum, and tungsten enzymes, along with catalytic roles within their active sites. With a uniform approach throughout, each chapter includes the structure and function of the enzyme, physiologic and pathologic roles, inhibitors and activators of the enzyme (and their design), and clinical agents or compounds applied in medicine and drug discovery. This book enables scientists across academia and industry to adopt ongoing metalloenzyme research, and continuous discovery of novel metalloenzymes, in new life science studies and clinical applications. - Examines a range of metalloenzymes, from biochemistry to pharmacology and drug design - Each chapter examines enzyme structure and function, physiologic and pathologic roles, inhibitors and activators, and clinical application - Features chapter contributions from international experts in the field




Evaluation Methodology Basics


Book Description

Evaluation Methodology Basics introduces evaluation by focusing on the main kinds of 'big picture' questions that evaluations usually need to answer, and how the nature of such questions are linked to evaluation methodology choices. The author: shows how to identify the right criteria for your evaluation; discusses how to objectively figure out which criteria are more important than the others; and, delves into how to combine a mix of qualitative and quantitative data with 'relevant values' (such as needs) to draw explicitly evaluative conclusions.




Novel Synthesis and Characterization of Nanostructured Materials


Book Description

Nanostructured materials have been largely studied in the last few years. They have great potential of applications in different fields such as materials science, physics, chemistry, biology, mechanic and medicine. Synthesis and characterization of nanostructured materials is a subject of great interest involving science, market, politicians, government and society. Based on results obtained by the authors' research group during the past decade, this book comes to present novel techniques to synthesize nanostructured materials and characterize their properties such as crystallinity and crystallite size, specific surface area, particle size, morphology and catalytic activity. This book is aimed for students, researchers and engineers searching for methodologies to obtain and characterize nanostructures in details.




Handbook of EHealth Evaluation


Book Description

To order please visit https://onlineacademiccommunity.uvic.ca/press/books/ordering/




Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set


Book Description

Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.




Drug Classes: Advances in Research and Application: 2011 Edition


Book Description

Drug Classes: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Drug Classes. The editors have built Drug Classes: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Drug Classes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Drug Classes: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.




Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds


Book Description

Natural products play crucial roles in modern drug development, and constitute a prolific source of novel lead compounds or pharmacophores for ongoing drug discovery programs. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds presents cutting-edge research in the chemistry of bioactive natural products and demonstrates how natur




Research Awards Index


Book Description