Author : Peng George Wang
Publisher :
Page : 214 pages
File Size : 31,31 MB
Release : 2004
Category : Language Arts & Disciplines
ISBN :
Synthesis of Carbohydrates Through Biotechnology describes rapid developing and cutting-edge new technologies in glycoscience. These new approaches combine advantages of molecular biology, genetic engineering and chemistry, and provide access to synthetic carbohydrates.
Author : Christopher Bucke
Publisher : Springer Science & Business Media
Page : 334 pages
File Size : 30,24 MB
Release : 2008-02-05
Category : Science
ISBN : 1592592619
We are in a phase of the evolution of biotechnology in which the true and potential commercial importance of carbohydrates is becoming appre- ated more fully. Progress in providing hard facts to establish the commercial value ofpolysaccharides and oligosaccharides is limited, as always, by lack of funding and by a relative shortage of skilled practitioners in the production and analysis of those materials. Carbohydrate science has a reputation, not unmerited, for technical difficulty owing to the structural similarity of the many monosaccharide monomers and the potential, and real, complexity of oligosaccharides and polysaccharides, particularly heterosaccharides conta- ing many different monomers. Modem analytical and synthetic methods, in many cases using enzyme technology, are beginning to allow this complexity to be unraveled. Carbohydrate Biotechnology Protocols is aimed at those newcomers who have an interest in the production and use of carbohydrate materials, but have shied away from involvement for lack of detailed descriptions of appropriate methods, including the type of practical hints that may be provided by those skilled in those methods, but that are rarely described in research papers. The majority of the contributions to this book conform to the established format of the Methods in Biotechnology series. They begin with the theoretical and c- mercial background to the method or group of methods, provide a list of the reagents and equipment required for the procedure, then give a detailed st- by-step description of how to carry out the protocol.
Author : Mark D. Bednarski
Publisher :
Page : 152 pages
File Size : 18,96 MB
Release : 1991
Category : Medical
ISBN :
Not only assessing the past, present, and future uses of enzymes to synthesize carbohydrates, this volume also illustrates the significance of carbohydrate chemistry and describes how the combination and use of modern enzyme chemistry can advance exploration in the field. Details research at the interface of chemistry and biology for carbohydrate chemistry by demonstrating how to integrate chemical reactions and biological techniques that can be used to synthesize complex bioactive monosaccharides, oligosaccarides, and glycoconjugates. Of particular interest are chapters by George Whitesides and Chi-Huey Wong covering the use of enzymes in monosaccharide synthesis, and Hindsgaul, Thiem, Nilsson, and Whitesides describing the use of activated sugar nucleosides and glycosyltransferases in the synthesis of oligosaccharides and polysaccharides.
Author : Tuula T Teeri
Publisher : Royal Society of Chemistry
Page : 208 pages
File Size : 41,88 MB
Release : 2007-10-31
Category : Science
ISBN : 1847550320
Carbohydrate bioengineering is a rapidly expanding field with many applications in medicine and industry. Presenting state-of-the-art research, Carbohydrate Bioengineering: Interdisciplinary Approaches brings together international experts on many different aspects of this burgeoning topic. Coverage includes: the engineering of glycosidases for constructive purposes; structure-function studies and protein engineering of carbohydrate-active enzymes; chemo-enzymatic carbohydrate synthesis; and trends emerging from comprehensive work on genomes and glycomes. This timely publication will be welcomed by all those needing access to the latest research in the field, including practitioners in the medicinal, chemical, food and pharmaceutical areas.
Author : Amélia Pilar Rauter
Publisher : Elsevier
Page : 492 pages
File Size : 32,53 MB
Release : 2020-05-13
Category : Science
ISBN : 0128174676
Carbohydrate chemistry provides access to carbohydrate-based natural products and synthetic molecules as useful biologically active structures relevant to many health care and disease-related biological processes. Recent Trends in Carbohydrate Chemistry: Synthesis, Structure, and Function of Carbohydrates covers green and sustainable reactions, organometallic carbohydrate chemistry, synthesis of glycomimetics, multicomponent reactions, and chemical transformations leading to molecular diversity based on carbohydrates. These include inhibitors of glycogen phosphorylase, which are relevant in controlling type 2 diabetes and sugar sulfates. Polysaccharides, which are commonly modified chemically, are also examined with contributions covering polysaccharide synthesis and modification of polysaccharides to obtain new structures and properties. Recent Trends in Carbohydrate Chemistry: Synthesis, Structure, and Function of Carbohydrates is ideal for researchers working as synthetic organic chemists, and for those interested in biomolecular chemistry, green chemistry, organometallic chemistry, and material chemistry in academia as well as in industry Demonstrates the importance of carbohydrate chemistry as green and sustainable chemistry Details monosaccharide syntheses and transformations toward biologically active small molecular entities Provides the most recent findings on polysaccharide synthesis and bioapplications
Author : Wanmeng Mu
Publisher : Springer Nature
Page : 289 pages
File Size : 42,98 MB
Release : 2021-03-20
Category : Science
ISBN : 9813360216
This book focuses on the latest research and new techniques in the field of functional carbohydrate-related enzymes. Carbohydrates are a key form of energy for most organisms. The “good” carbohydrates generally refer to functional carbohydrates. In addition to the low or moderate energy-supplying function, they have more nutritious value than traditional carbohydrates and some of them also have health-promoting effects especially prebiotic actions. Several enzymatic methods for the synthesis of such carbohydrates have been discovered and developed in the recent decades, providing a new range of application areas for these novel enzymes. This book addresses the classification of functional carbohydrate-related enzymes and the overall development in food enzyme in Chapter 1. Chapters 2-5 describe the isomerases or epimerases involved in the production of rare sugars, such as D-allulose, D-mannose, D-tagatose, and D-allose. While the studies of the enzymes related to fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS) dominate the scientific literature in the field of enzymatic production of health-functional oligosaccharides, some enzymes also show promise for the emerging oligosaccharide production, which are introduced in Chapters 6-8. Chapters 9-12 summarize the new enzymatic technologies and applications in fructan- and glycan-related industries. The last Chapter gives an overall prospective on the trends of enzymatic functional carbohydrate production. This book is a valuable resource for researchers and graduate students in the fields of biotechnology, enzyme engineering, and carbohydrate production, as well as the health industry.
Author : Vinod Kumar Tiwari
Publisher : Elsevier
Page : 775 pages
File Size : 43,43 MB
Release : 2023-11-01
Category : Science
ISBN : 0323986498
Synthetic Strategies in Carbohydrate Chemistry covers carbohydrate synthesis and its widespread application in various disciplines including catalysis. Basic and advanced aspects of carbohydrates are covered, starting with a brief introduction and then followed by protection-deprotection strategies in carbohydrate chemistry, glycosidic bond formation methodology, and their impact in oligosaccharide synthesis. Recent synthetic approaches for O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), and carbohydrate modification are discussed, as well as stereoelectronic factors that control the chemical and biochemical behavior of carbohydrates in living cells. In addition, diverse applications of synthetic carbohydrate chemistry are covered, including sugar-based chiral catalyst in stereoselective synthesis, sugar-based ionic liquids, one-pot tandem reactions in carbohydrates, total synthesis of glycoconjugated natural products, impact of sugar in drug discovery and development, vaccine development, and glycoengineering. This reference is essential reading for researchers working in synthetic carbohydrate chemistry and biochemistry, and will be useful to those working in total synthesis, novel synthetic methodology, catalysis, polymer science, glycobiology, medicinal chemistry, and process development chemistry. Presents a practical and detailed overview on glycosylation methodology Covers automated glycosylation strategies in glycan synthesis Includes recent progress in the synthesis and significance of diverse thio-glycosides, C-glycosides, imino sugars and carbasugars Highlights the impact of enzymes in glycan synthesis Discusses the recent approaches for the synthesis of neoglycoconjugates
Author : Shaheer H. Khan
Publisher : CRC Press
Page : 580 pages
File Size : 38,61 MB
Release : 2020-08-26
Category : Science
ISBN : 1000159485
Modern Methods in Carbohydrate Synthesis presents in one volume a sequence of chapters leading from classical methods through to today's newest state-of -the-art technology for oligosaccharide synthesis. It places particular emphasis on the most recent breakthroughs in the field, including emerging technologies for both oligosaccharide and glycoconjugate synthesis. Chapters describing the synthesis of increasingly important glycosidic linkage analogs, as well as the oligosaccharides containing derivatives and analogs of natural sugars are included. While chemical-synthetic methods constitute the major part of the book, completing the volume is a section on the rapidly expanding and important field of enzymatic synthesis, also covering combined chemical and enzymatic synthesis. Chapters are written by leading experts in the field. Wherever possible, methods of synthesis are provided in sufficient detail to allow the reader to implement the techniques described. More than 1700 references are provided in the 21 chapters comprising the book. This volume should provide a wealth of information to a large number of synthetic organic chemists, medicinal chemists, protein chemists, biochemists, glycobiologists and cell biologists, including students in these fields.
Author : A.K. Gupta
Publisher : Elsevier
Page : 381 pages
File Size : 22,8 MB
Release : 2000-09-05
Category : Science
ISBN : 0080528503
Carbohydrate reserves constitute the major part of edible portion of the plants. Latest researches in major crops like wheat, rice, maize, barley, potato, sugarcane, sugarbeet, Jerusalem artichoke, chicory and carbohydrates in trees have been included in this book. The book will be of great value to the basic plant biochemists, molecular biologists, biotechnologists, and genetic crop engineers and to the agricultural scientists working in different disciplines related to crop productivity. This compilation may act as a medium to initiate discussions among these scientists leading to new researches in the area of crop productivity and reserve carbohydrate metabolism.
Author : S.B. Petersen
Publisher : Elsevier
Page : 385 pages
File Size : 24,55 MB
Release : 1995-12-08
Category : Technology & Engineering
ISBN : 0080528511
The Carbohydrate Bioengineering Meeting held in Elsinore, Denmark, April 23-26, 1995, gathered 230 scientists, mostly from Europe, with interest in carbohydrate analysis and structure; carbohydrates in medicine and glycopathology; structure, function, application, and protein engineering of carbohydrate active enzymes; oligo- and polysaccharides of industrial interest; and production of carbohydrate containing new materials. The first chapters address glycoconjugates as modulatory and recognition molecules, structure determination using NMR and mass spectrometry, and microdialysis-chip enzyme-based sensors. Active site mutations coupled with crystal structures and synthetic substrate analogue interactions as well as new three-dimensional structures and binding domains for biotechnological applications are included in the chapters. Carbohydrate active enzymes turned out to be a predominant topic. The rapid development in glycobiology and glycotechnology has resulted in an enormous increase in our knowledge on the structure conversion, and application of carbohydrates in industry and medicine.
