Book Description
The development of efficient routes for the preparation of complex oligosaccharide or carbohydrate conjugates has been our immediate purpose. A more global goal would be that of recruiting the immune system to respond to malignant lesions. In our continuing chemical studies, we have undertaken to develop synthetic methodology of general applicability for the preparation of carbohydrates, in the form of glycolipids and glycopeptides, which mimic components of the accessible cell surface of tumor cells. The report herein focuses on successful syntheses of mucin related 0-linked glycopeptides, in particular the TF and 2,3-STF antigens. TF is observed on a variety of epithelial tumors and 2,3-STF is observed on a large number of breast tumors.